Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients

Abstract

10 years into PD, a significant proportion of patients developed dopa resistant motor and non-motor features. Older onset, PIGD type, PIPon and dementia had a negative impact on survival. Standardised mortality ratio was 1.1.

A systematic review of loss of independence in Parkinson’s disease

“…Five studies were inception cohorts (studies recruiting only patients at or near diagnosis) [5,11,12,16,19] and nine were non-inception cohorts (e.g. prevalence studies, consecutive series) [10, 13-15, 17, 18, 20-22].…”

“…Thirteen studies were hospital based [5,10,[12][13][14][15][16][17][18][19][20][21][22] and one was community based [11]. Nine studies were retrospective [5,12,14,15,17,18,[20][21][22] and five were prospective [10,11,13,16,19]. One study was published before the introduction of levodopa [5], three straddled its introduction [15,18,20] and the rest were carried out when levodopa was widely available [10-14, 16, 17, 19, 21].…”

Cognitive deficits in Parkinson’s disease: current perspectives

“…[1][2][3] The Sydney Multicenter Study -the longest published follow-up of a newly diagnosed PD cohort to date -found that 83% of those alive at 20 years had developed PDD and 75% developed PDD before death,…”

“…A spectrum of cognitive deficit is associated with PD, from subjective cognitive decline (PD-SCD) to mild cognitive impairment (PD-MCI) and dementia (PDD). Longitudinal cohort studies have demonstrated that approximately half of those diagnosed with PD for 10 years develop PDD, [1][2][3] while the point prevalence of dementia among those with PD is between 35% and 30%. 4 In context, PDD accounts for 3%-4% of dementia of all types within the general population, a much smaller percentage than Alzheimer's disease (AD; 50%-70%) or vascular dementia (15%-25%).…”

Multidisciplinary care with deep brain stimulation for Parkinson’s disease patients

“…As the disease progresses, new symptoms emerge that are levodopa-resistant and become the dominant causes of death and disability. 8,9 Modern health care also underscores patient-centred care and patient empowerment, which highlights patient preferences and their own decision-making. Hence, it is generally accepted that a multidisciplinary health care model is preferable to a monodisciplinary model.…”