Ten years of global monitoring under the Stockholm Convention on Persistent Organic Pollutants (POPs): Trends, sources and transport modelling

Hung, Hayley; Katsoyiannis, Athanasios; Guardans, Ramón

doi:10.1016/j.envpol.2016.05.035

Cited by 49 publications

(24 citation statements)

References 18 publications

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“…POPs are widely dispersed environmental contaminants, including, among others, polybrominated‐diphenyl ethers (PBDEs), polychlorobiphenyls (PCBs), polychlorinated dibenzo‐ p ‐dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), which are all characterized by resistance to biodegradation, environmental persistence, bioaccumulation in the food chain, and toxicity for human health (El‐Shahawi, Hamza, Bashammakh, & Al‐Saggaf, ; Lee, Kim, Jacobs, & Lee, ). POPs were largely used in the industry, and, despite the ban on their use by the Stockholm Convention on Persistent Organic Pollutants in 2001, they can still be released into the environment mainly owing to the industrial emission or incineration of municipal and industrial waste (Esposito et al, ; Hung, Katsoyiannis, & Guardans, ; Trivedi & Majumdar, ). The World Health Organization (WHO) raised awareness about POP impact on environment and human health, thus encouraging several studies, which demonstrated the association of the exposure to these compounds with cancer development, reproductive problems, neurobehavioral disorders, abnormalities in fetal development, immune alteration, and disruption of hormones (Darras, ; Gregoraszczuk & Ptak, ; Hardell, Bavel, Lindstrom, Eriksson, & Carlberg, ; Lim et al, ; Tran & Miyake, ).…”

Section: Introductionmentioning

confidence: 99%

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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In Italy, in the eastern area of the Campania region, the illegal dumping and burning of waste have been documented, which could potentially affect the local population's health. In particular, toxic waste exposure has been suggested to associate with increased cancer development/mortality in these areas, although a causal link has not yet been established. In this pilot study, we evaluated blood levels of toxic heavy metals and persistent organic pollutants (POPs) in 95 patients with different cancer types residing in this area and in 27 healthy individuals. While we did not find any significant correlation between the blood levels of POPs and the provenance of the patients, we did observe high blood concentrations of heavy metals in some municipalities, including Giugliano, where many illegal waste disposal sites have previously been documented. Our results showed that patients with different cancer types from Giugliano had higher blood levels of heavy metals than healthy controls. Despite the obvious limitations of this exploratory study, our preliminary observations encourage further research assessing the possible association between exposure to hazardous waste, increased blood metals, and increased risk of cancer.

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Section: Introductionmentioning

confidence: 99%

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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“…Persistent organic pollutants (POPs) refers to groups of toxic environmental chemicals with a carbon-based structure, resistant to environmental degradation and widely distributed via soil, water and air [1]. Because of their lipophilic nature, POPs tend to bioaccumulate in top predators and humans [2].…”

Section: Introductionmentioning

confidence: 99%

A Mixture of Persistent Organic Pollutants and Perfluorooctanesulfonic Acid Induces Similar Behavioural Responses, but Different Gene Expression Profiles in Zebrafish Larvae

Khezri

Fraser

Nourizadeh-Lillabadi

et al. 2017

IJMS

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Persistent organic pollutants (POPs) are widespread in the environment and some may be neurotoxic. As we are exposed to complex mixtures of POPs, we aimed to investigate how a POP mixture based on Scandinavian human blood data affects behaviour and neurodevelopment during early life in zebrafish. Embryos/larvae were exposed to a series of sub-lethal doses and behaviour was examined at 96 h post fertilization (hpf). In order to determine the sensitivity window to the POP mixture, exposure models of 6 to 48 and 48 to 96 hpf were used. The expression of genes related to neurological development was also assessed. Results indicate that the POP mixture increases the swimming speed of larval zebrafish following exposure between 48 to 96 hpf. This behavioural effect was associated with the perfluorinated compounds, and more specifically with perfluorooctanesulfonic acid (PFOS). The expression of genes related to the stress response, GABAergic, dopaminergic, histaminergic, serotoninergic, cholinergic systems and neuronal maintenance, were altered. However, there was little overlap in those genes that were significantly altered by the POP mixture and PFOS. Our findings show that the POP mixture and PFOS can have a similar effect on behaviour, yet alter the expression of genes relevant to neurological development differently.

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“…Moreover, new evidence associates dioxin exposure with unexplained miscarriages (Fan, Su, Yang, & Zhao, ), high impact diseases such as diabetes (Ngwa, Kengne, Tiedeu‐Atogho, Mofo‐Mato, & Sobngwi, ) and proposes the molecular toxicity mechanism as a possible anticancer target (Safe, Cheng, & Jin, ). Multiple factors have compromised the execution of the Stockholm treaty, most notably regarding dioxin detection (Hung, Katsoyiannis, & Guardans, ). POPs such as 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) are typically found at low concentrations ranging from a few femtograms per gram of solid sample to a few nanograms per liter of liquid sample.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, new evidence associates dioxin exposure with unexplained miscarriages (Fan, Su, Yang, & Zhao, 2017), high impact diseases such as diabetes (Ngwa, Kengne, Tiedeu-Atogho, Mofo-Mato, & Sobngwi, 2015) and proposes the molecular toxicity mechanism as a possible anticancer target (Safe, Cheng, & Jin, 2017). Multiple factors have compromised the execution of the Stockholm treaty, most notably regarding dioxin detection (Hung, Katsoyiannis, & Guardans, 2016).…”

Section: Introductionmentioning

confidence: 99%

Aryl hydrocarbon receptor‐based bioassays for dioxin detection: Thinking outside the box

Otarola

Castillo

Marcellini

2017

J of Applied Toxicology

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Despite intensive media coverage and international regulations, man-made persistent organic pollutants such as dioxins represent a serious environmental and health threat. Their detection by sophisticated chromatography technologies is highly complex, impeding the constant monitoring of food or environmental samples. This limitation has fostered the development of generations of bioassays exploiting the molecular function of the aryl hydrocarbon receptor (AhR), which binds toxic compounds and directly activates the transcription of target genes. Here, we review the rich panel of available AhR-dependent bioassays and propose a novel classification based on the source of AhR, which can either be endogenously produced by cell types or tissues naturally responsive to dioxins, or exogenously introduced into a wide range of cellular contexts. In both cases, in vitro and in vivo strategies have been engineered to monitor the formation of molecular complexes, and the activation of direct downstream targets or reporter genes. We evaluate and compare bioassays based on exogenous and endogenous AhR proteins and discuss their specific challenges, strengths and opportunities for futures applications. Undoubtedly, the dynamic field of AhR-dependent bioassays will keep providing new and original strategies to help protect human health and ecosystems from persistent organic pollutants.

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Ten years of global monitoring under the Stockholm Convention on Persistent Organic Pollutants (POPs): Trends, sources and transport modelling

Cited by 49 publications

References 18 publications

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

A Mixture of Persistent Organic Pollutants and Perfluorooctanesulfonic Acid Induces Similar Behavioural Responses, but Different Gene Expression Profiles in Zebrafish Larvae

Aryl hydrocarbon receptor‐based bioassays for dioxin detection: Thinking outside the box

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