This Symposium aims to replenish geographical thinking in relation to the depletion that is entailed through social reproduction labour, and the wider, structural depletion of social reproduction that is continuing apace in capitalist times. In this introduction, we trace the existing contours of how depletion through social reproduction has come to be conceptualised. Thereafter, we focus on four areas of development that the four spatially oriented papers of the Symposium probe at: first, on the links between harm and depletion; second, on depletion both through and of social reproduction; third, on the methods that are harnessed to examine depletion; and fourth, on the possibility and limits of appreciation and repair.