Tendon Tissue Engineering: Mechanism and Effects of Human Tenocyte Coculture With Adipose-Derived Stem Cells

Long, Chao; Wang, Zhen; Legrand, Anaïs; Chattopadhyay, Arhana; Fox, Paige M.

doi:10.1016/j.jhsa.2017.07.031

Cited by 18 publications

(18 citation statements)

References 49 publications

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“…The second group includes models investigating the interaction of MSC with tenocytes and/or the tendon ECM, using co-cultures of MSC and tenocytes, their respective conditioned media, or tendon explants [48,69,74,75,88,91,92,94,[96][97][98][99][100][101][102][103][104][105].…”

Section: Tendon Regeneration and Defect Models 21 In Vitro And Ex VImentioning

confidence: 99%

“…Trophic effects on tenocytes were demonstrated in vitro, when ASC and BMSC, as well as BMSC-conditioned medium, promoted the proliferation of tenocytes [94,102,103]. Furthermore, ASC as well as BMSC-conditioned medium promoted tenocyte migration [102,103], and ASC promoted healing in a microwound model [92]. In vivo, results are inconsistent as to whether BMSC and ASC decrease [137,141] or increase [117] cellularity within healing tendons.…”

Section: Trophic Support and Pro-angiogenetic Effectsmentioning

confidence: 99%

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Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Burk¹

2019

Tendons

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Multipotent mesenchymal stromal cells (MSCs) are a promising therapeutic tool to treat tendon disease. Aiming to establish successful treatment approaches and to fully exploit the regenerative potential of the MSC, it is crucial to understand their mechanisms of action. However, these can be multifaceted and strongly context-sensitive and are still not well-understood in the context of tendon disease. This review aims to shed light on the different possible mechanisms, including engraftment, tenogenic differentiation, extracellular matrix synthesis and remodeling, immunomodulation, pro-angiogenetic effects, trophic support, and protection of resident tendon cells. Evidence from experimental and clinical (veterinary) case studies was compiled and interpreted in conjunction with the respective in vitro and animal models used.

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Section: Tendon Regeneration and Defect Models 21 In Vitro And Ex VImentioning

confidence: 99%

Section: Trophic Support and Pro-angiogenetic Effectsmentioning

confidence: 99%

Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Burk¹

2019

Tendons

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“…Mesenchymal stem cells -plentiful throughout the body -are also promising potential donors, but may form ectopic calcium deposits in the tendon after transplantation [22]. Stem cell introduction to injured tendons may lead to a synergistic healing reaction with native cells; Long et al demonstrated that co-culture of adipocyte derived stem cells and tenocytes lead to improved cell proliferation, type 1 collagen deposition, and tenocyte migration than monoculture controls [23]. Fat grafting clinically demonstrates beneficial effects on the recovery of radiated skin, and this is theorized to be due in part to transfer of adiposity derived stem cells [24].…”

Section: Future Treatment Paradigmsmentioning

confidence: 99%

Untitled

2018

JSCR

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CellsVascular supply arises from blood vessels entering at the myotendinous junction, running parallel to the tendon fibers and within the endotenon. In the flexor tendons of the phalanges, additional fibrous bands, vincula, provide additional blood supply, while the synovial sheath also provides additional dorsal blood supply [7]. Around regions of maximal tendon excursion and pulley Abstract Tendons form the crucial connections linking muscles to bones, allowing movement of the axial and appendicular skeleton. Hand injuries often involve tendinous injury which may severely impair daily function. Current clinical treatment strategies for tendon injuriesare suboptimal, requiringimmobilization and prolonged rehabilitation, but regenerative medicine presents promising future treatment strategies that may expedite return of function, improving long-term patient outcomes. In this review, we discuss current treatment paradigms for upper extremity tendon injuries, as well as the potential impact that emerging regenerative medicine and stem cell related strategies may bring to improving clinical treatment.

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“…Adipose-derived stem cells are easily harvested and differentiated toward a desired lineage [98] and amounts per gram of tissue are higher as compared to other stem cells sources like bone marrow [99]. Hence, these cells are very well suited for tissue engineering purposes, like tendon tissue engineering [100,101]. Among different stem cell sources, however, the best source of stem cells for tendon tissue engineering is reported to be tendon stem cells, although their availability is limited and the harvesting protocol everything else than easy [32].…”

Section: Cellular Approachesmentioning

confidence: 99%

Tissue Regeneration

2018

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Tendon Tissue Engineering: Mechanism and Effects of Human Tenocyte Coculture With Adipose-Derived Stem Cells

Cited by 18 publications

References 49 publications

Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Untitled

Tissue Regeneration

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