Tepid Modified Del Nido Cardioplegia in Adults Undergoing Cardiac Surgery: A PropensityMatched Analysis

Sevük, Utkan; Dursun, Seyithan; Ar, Elif Sevgi

doi:10.21470/1678-9741-2020-0422

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The most common rule is re-dosing ½ of the initial DNC dose after 60 minutes of XC if the expected total XC time is > 90 minutes. Many modifications to the re-dosing period or the volume and composition of the second DNC dose can be found in the literature [49][50][51][52]. The authors of the analyzed studies did not always include the protocols for administration and re-dosing of DNC.…”

Section: Questions and Limitations Of The Reviewmentioning

confidence: 99%

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Del Nido cardioplegia versus other contemporary solutions for myocardial protection – a literature review

Brzeska¹,

Karolak²,

Żelechowski³

et al. 2023

Eur J Trans Clin Med

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Myocardial protection is one of the most important factors ensuring patient safety during cardiac surgery with the application of cardiopulmonary bypass. Infusion of cardioplegic solution into the coronary circulation protects the heart and provides a standstill operating field for the surgeon. Cold blood cardioplegia and crystalloid cardioplegia are the two main types of solutions with a long history of use and a large amount of research proving their efficacy and safety. Relatively new del Nido cardioplegia seems to be an interesting alternative. We reviewed the literature comparing del Nido cardioplegia with two other types of cardioplegic solutions. We took into consideration many different clinical and biochemical aspects may indicate the quality of cardioprotection.

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Section: Questions and Limitations Of The Reviewmentioning

confidence: 99%

“…Eur J Transl Clin Med 2023;6(1):[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] …”

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Del Nido cardioplegia versus other contemporary solutions for myocardial protection – a literature review

Brzeska¹,

Karolak²,

Żelechowski³

et al. 2023

Eur J Trans Clin Med

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Comparison of routine del Nido cardioplegia vs two types of modified del Nido cardioplegias for myocardial protection among patients undergoing coronary artery bypass grafting (CABG) surgeries: A randomized double-blind clinical trial

Ali,

Butt,

Nour

et al. 2024

J Extra Corpor Technol

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Background: The del Nido Cardioplegia Solution is a widely used method for myocardial protection in various settings. However, there is limited evidence of its effectiveness in adult cardiac surgery, and the baseline solution, Plasma Lyte A, is not readily available, leading to the use of alternative baseline solutions. This study aims to investigate the effectiveness of routine del Nido cardioplegia in adult cardiac surgery and the impact of different baseline solutions on myocardial protection and other perioperative outcomes. Methods: This study was a prospective, double-blind randomized parallel group clinical trial conducted at a single tertiary care hospital in Iran. A total of 187 adult patients were evaluated for eligibility, of which 120 met the inclusion criteria for elective isolated CABG surgery. The patients were randomly assigned to three groups, with each group consisting of 40 patients. The control group received normal saline-based routine del Nido cardioplegia, Intervention Group A received ringer lactate-based del Nido cardioplegia, and Intervention Group B received plain ringer-based del Nido cardioplegia. The levels of CK-MB, Troponin T, Troponin I, and lactate were primarily assessed at four different times: after anesthesia induction (Baseline), 2 hours, 12 hours, and 24 hours. Results: Preoperative demographic and clinical characteristics were the same among groups with insignificant differences (p > 0.05). There was no significant difference among groups based on CK-MB, Troponin T, Troponin I, and lactate levels (p=0.078, 0.143, 0.311, and 0.129 respectively). However, there was a significant difference in the time effect of Troponin T and Lactate (p=0.034, p= < 0.001). Conclusion: Normal saline, Ringer lactate, and plain Ringer provide comparable myocardial protection in adult-isolated CABG surgery with modified del Nido cardioplegia. Larger studies are needed to identify the best alternative to Plasma Lyte A while maintaining del Nido Cardioplegia as the control.

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Tepid Modified Del Nido Cardioplegia in Adults Undergoing Cardiac Surgery: A PropensityMatched Analysis

Cited by 2 publications

References 19 publications

Del Nido cardioplegia versus other contemporary solutions for myocardial protection – a literature review

Del Nido cardioplegia versus other contemporary solutions for myocardial protection – a literature review

Comparison of routine del Nido cardioplegia vs two types of modified del Nido cardioplegias for myocardial protection among patients undergoing coronary artery bypass grafting (CABG) surgeries: A randomized double-blind clinical trial

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