Terahertz Biosensing Technology: Frontiers and Progress

Menikh, Abdellah; MacColl, Robert; Mannella, Carmen A.; Zhang, Xicheng

doi:10.1002/1439-7641(20020816)3:8<655::aid-cphc655>3.0.co;2-w

Cited by 68 publications

(40 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,4 Recently a new detection method based on terahertz wave operating on the same principal as SPR has been proposed, and used successfully to detect minute amounts of label-free DNA molecules. 5 This approach uses integrated THz waveguides, incorporating resonant THz structures.…”

mentioning

confidence: 99%

Amplification and modelling of bioaffinity detection with terahertz spectroscopy

et al. 2002

Self Cite

View full text Add to dashboard Cite

A new bioaffinity sensor based on pulsed terahertz (THz) spectroscopy is able to sensitively detect the presence of ultra-thin bound biomolecular layers. The protein avidin and lipid biotin are noted for their very high binding affinity, and the ease for which they can be attached to residues with importance in many biosensing applications. We demonstrate the sensitivity of the pulsed THz spectrometer to thin avidin layers and to avidin amplified with micron-sized agarose beads. The experimental results can be simply modelled by considering transmission of the THz radiation at the thin film interfaces. We detect less than 10.3 ng/cm 2 avidin, giving the THz system a detection capability of sub-thin solid films better than ellipsometry and reflectometry techniques.

show abstract

mentioning

confidence: 99%

Amplification and modelling of bioaffinity detection with terahertz spectroscopy

et al. 2002

Self Cite

View full text Add to dashboard Cite

show abstract

“…8.6c. Such a strong dependence of toroidal minimum can be exploited for fast and efficient on/off routing [19][20][21][22][23][24][25] and filtering purposes [26,27]. As a key parameter, we also computed the corresponding modulation-depth (MD) for the proposed metasurface as a function of microstructure's geometries, as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Tunable, Room Temperature THz Emitters Based on Nonlinear Photonics

Raju¹

View full text Add to dashboard Cite

All rights reserved. and development efforts, all the available state-of-the-art THz emitters suffer from either being large, complex and costly, or operating at low temperatures, lacking tunability, having a very short spectral range and a low output power. Hence, the major objective of this research was to develop simple, inexpensive, compact, room temperature THz sources with wide-range tunability.We investigated THz radiation in a hybrid optical and THz micro-ring resonators system. For the first time, we were able to satisfy the DFG phase matching condition for viii the above-mentioned THz range in one single device geometry by employing a modal phase matching technique and using two separately designed resonators capable of oscillating at input optical waves and generated THz waves. In chapter 6, we proposed a novel plasmonic antenna geometry -the dimer rod-tapered antenna (DRTA), where we created a hot-spot in the nanogap between the dimer arms with a very large intensity enhancement of 4.1×10 5 at optical resonant wavelength. Then, we investigated DFG operation in the antenna geometry by incorporating a nonlinear nanodot in the hot-spot of the antenna and achieved continuously tunable enhanced THz radiation across 0.5-10 THz range. In chapter 8, we designed a multi-metallic resonators providing an ultrasharp toroidal response at THz frequency, then fabricated and experimentally demonstrated an efficient polarization dependent plasmonic toroid switch operating at THz frequency.In summary, we have successfully designed, analytically and numerically investigated novel THz emitters with the advantages of wide range tunability, compactness, room temperature operation, fast modulation and the possibility for monolithic integration, which are the most sought after properties in the new generation THz sources.

show abstract

“…THz-TDS has been proposed in the biology area to recognize Deoxyribonucleic Acid (DNA) signatures [77]- [79], (an interesting method to find DNA mutation using compact genetic sensors based on compact coupled-line filters can be found in [80]); study protein properties [81], and analyze plant species [82], [83]. Food science may also take advantage from THz-TDS as reported in [84] and [85].…”

Section: Biologymentioning

confidence: 99%

“…Most of the early THz sytems incorporated scaled microwave designs, the easiest way to afford the firstly used THz frequencies [1], [79], [80], [167].…”

Section: Metallic (Microwave) Waveguides and Transmission Linesmentioning

confidence: 99%

“…To finish this apart, it must be highlighted that, since communications regulatory organisms fix the employable bands, other kind of applications are consequently allocated in free-used bands or unlicenced spectrum. Radar has been mainly focused around 77 GHz, being the available bands [76][77] and [79][80][81], [604]- [606]. Alternatively, some proposals are found around 24 GHz and 94 GHz, this last more dedicated to military and scientific uses.…”

Section: Frequency Bandwidth and Regulationmentioning

confidence: 99%

See 1 more Smart Citation

Analysis and design of efficient passive components for the millimeter-wave and THz bands

Verdú¹,

Antonio²

View full text Add to dashboard Cite

To my parents, brother and sister."Success is peace of mind which is a direct result of self-satisfaction in knowing you made the effort to become the best of which you are capable."Jonh Wooden "Lo que con mucho trabajo se adquiere, más se ama." Aristóteles AgradecimientosLa realización de esta tesis ha implicado no pocos años de trabajo y esfuerzo. Durante este importante periodo de mi vida han sido muchas las personas han estado a mi lado, brindándome su apoyo, ayuda, cariño y amor. Ya sea de una forma u otra, todas estas personas han contribuido a que este trabajo haya sido posible dando como fruto esta tesis. A todos ellos, me gustaría dedicarles un agradecimiento muy especial de todo corazón.Sin duda alguna, debo dar las gracias en primer lugar a mi director de tesis Mariano Baquero. Mariano, has sido un padre para mí profesionalmente hablando. Te conocí como alumno en las clases de Microondas, en las cuales me abriste la puerta a un conocimiento que me fascinó.Recuerdo perfectamente cuando fui a verte para preguntarte si podrías dirigirme el Proyecto Final de Carrera, y desde ese año 2009 hemos estado trabajando juntos. Quiero agradecerte no sólo haberme dado la oportunidad de trabajar en cada momento en elárea que más me ha gustado, sino el haberte preocupado por mí a nivel personal, velando siempre por mis intereses, ayudándome a desarrollarme personal y profesionalmente. Extiendo en este sentido mi agradecimiento a Miguel Ferrando. Si Mariano es el padre, tu serías sin duda el abuelo. Sin tu ayuda, la beca para la realización de esta tesis y los proyectos que han respaldado la misma no hubieran sido posibles. Tu esfuerzo ha permitido que el Grupo de Radiación Electromagnética (GRE) esté hoy dónde esta y que sus miembros nos beneficiemos de un entorno de trabajo excelente, produciendo trabajo de calidad. Debo agradecerte también tus siempre innovadoras ideas, algunas de las cuales se han convertido en una realidad plasmada en esta tesis.Una mención especial merece Daniel Sánchez. Dani, aunque tu nombre no figure como co-director bien sabes que podría estarlo. Jamás podré agradecerte lo suficiente la ayuda que me has prestado. Cuántas horas dedicadas a enseñarme en un sin fin de aspectos sin esperar nada a cambio, apoyándome también en los momentos difíciles, siempre presentes en una tesis. Bien sabes que lo mismo has hecho con cada uno tus compañeros, por eso eres el pilar del GRE Dani.Otra persona a la que estoy muy agradecido es a Vicente Boria. Tu activa colaboración en la dirección de esta tesis ha sido indispensable para la consecución de los resultados más relevantes de la misma. Sugeriste muy acertadamente una estancia en la Queen's University of Belfast, y me abriste la puerta a nuevas líneas de investigación en las cuales seguimos trabajando actualmente. Gracias por preocuparte por mi a nivel profesional y personal.En elámbito anterior, extiendo los agradecimientos a todo el GRE. It is also very important for me to acknowledge Prof. Vince Fusco. Thank you for hosting me in your group in Belfast ...

show abstract

Terahertz Biosensing Technology: Frontiers and Progress

Cited by 68 publications

References 7 publications

Amplification and modelling of bioaffinity detection with terahertz spectroscopy

Amplification and modelling of bioaffinity detection with terahertz spectroscopy

Tunable, Room Temperature THz Emitters Based on Nonlinear Photonics

Analysis and design of efficient passive components for the millimeter-wave and THz bands

Contact Info

Product

Resources

About