Terahertz Characteristic Absorption Spectral Analysis of Metronidazole

Guilin, 李桂琳 Li; Hu, 邓琥 Deng; Quancheng, 刘泉澄 Liu; Zhicheng, 郭志成 Guo; Qi, 张祺 Zhang; Liping, 尚丽平 Shang

doi:10.3788/lop57.173001

Cited by 2 publications

(2 citation statements)

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“…The nitroimidazole antibiotic metronidazole is used against trichomonas and amoeba, but has also been used widely against anaerobes in recent years ( Gui et al, 2011 ; Doron et al, 2017 ). Li et al recorded the THz spectra of analytically pure metronidazole and oral solutions of metronidazole with different mass fractions (20%, 30%, 40% and 50%), and obtained their absorption characteristic peaks in the 0.2–2.0 THz band ( Li G. L. et al, 2020 ). Characteristic absorption peaks at 1.36 and 1.67 THz were noted, and there was an obvious linear relationship between the absorption intensity and mass fraction of metronidazole.…”

Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Huang

Deng

Xia

et al. 2023

Front. Bioeng. Biotechnol.

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Terahertz time-domain spectroscopy is an analytical method using terahertz time-domain pulses to study the physical and chemical properties of substances. It has strong potential for application in pharmaceutical analyses as an original non-destructive, efficient and convenient technology for spectral detection. This review briefly introduces the working principle of terahertz time-domain spectroscopy technology, focuses on the research achievements of this technology in analyses of chemical drugs, traditional Chinese medicine and biological drugs in the past decade. We also reveal the scientific feasibility of practical application of terahertz time-domain spectroscopy for pharmaceutical detection. Finally, we discuss the problems in practical application of terahertz time-domain spectroscopy technology, and the prospect of further development of this technology in pharmaceutical analyses. We hope that this review can provide a reference for application of terahertz time-domain spectroscopy technology in pharmaceutical analyses in the future.

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Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Huang

Deng

Xia

et al. 2023

Front. Bioeng. Biotechnol.

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show abstract

“…Terahertz spectroscopy, as a complementary spectral technique to infrared and Raman spectroscopy, has developed in the past two decades as a new analytical tool for molecular structure analysis [6]. Terahertz wave refers to electromagnetic waves in the 0.1-10THz band, which is able to excite and detect intermolecular weak interactions, perceive the molecular skeletal vibrations and the lattice low-frequency vibrations [7].…”

Section: Introductionmentioning

confidence: 99%

Theory and experiment on the terahertz vibrational spectrum of ferulic acid

Chang,

Liang,

Wei

et al. 2024

J. Opt. Soc. Am. B

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Ferulic acid (FA, C10H10O4), a type of hydroxycinnamic acid derivative, has beneficial pharmacological effects and biological activities and is known for its high application value in medicine, health care, and cosmetic products. The vibration spectrum of FA ranging from 0.3 THz to 2.0 THz has been investigated by terahertz time-domain spectroscopy. The characteristic absorption peaks located at 0.937, 1.159, 1.464, 1.694, and 1.910 THz are obtained experimentally. To understand the origin of the characteristic absorption peaks of FA, density functional theory calculations based on isolated molecule and crystalline structure are separately performed to differentiate the intramolecular and intermolecular vibrational modes. Combined analysis of the experimental and theoretical results informs that the characteristic absorption peak at 1.464 THz comes from intramolecular interaction, and the ones at 0.937, 1.159, 1.694, and 1.910 THz originate from intermolecular collective vibrational modes.

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Terahertz Characteristic Absorption Spectral Analysis of Metronidazole

Cited by 2 publications

References 0 publications

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Theory and experiment on the terahertz vibrational spectrum of ferulic acid

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