Terahertz Imaging for Breast Cancer Detection

Wang, Lulu

doi:10.3390/s21196465

Cited by 42 publications

(33 citation statements)

References 90 publications

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“…Among them, the technology based on terahertz (THz) frequency waves is gaining popularity as a powerful nondestructive sensing tool owing to its unique capabilities of high transparency for soft materials and resonant response with intermolecular vibration [ 6–8 ]. Various studies have been conducted on the practical use of THz sensing, including material science [ 9–12 ], component fabrication (such as emitters and detectors) [ 13–15 ], system development [ 16 , 17 ], and sensing applications [ 18 , 19 ]. In the case of component fabrication, the challenge is to create a structure that efficiently couples with a THz wave, having a rapid cycle time of sub-picoseconds and small photon energy amounting to several meV.…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotube-based, serially connected terahertz sensor with enhanced thermal and optical efficiencies

Suzuki

Takida

Kawano

et al. 2022

Science and Technology of Advanced Materials

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Owing to their high thermal and optical performances, carbon nanotube (CNT) films are used in various photo-thermo-electric (PTE) applications, such as terahertz (THz) sensing and energy harvesting. To improve the performance of PTE devices, a device structure should be designed based on a deep understanding of the thermal and optical responses of the CNT film. However, the optical properties of CNT films in the THz frequency region remain unclear because of the difficulties associated with device processing and measurements. Herein, we report our findings on the thermal and optical characteristics of CNT films. The shape of the CNT film that maximizes the product of the thermal and optical factors (optimal structure of the PTE sensor) depends on the frequency of the irradiating electromagnetic wave. The optimal film thickness and width values for THz irradiation range from 300–600 nm and 50–70 µm, respectively. Subsequently, we fabricated a serially connected, multi-element PTE sensor with an optimal device structure and enhanced the detection sensitivity by approximately 13 times compared with a single-element PTE sensor. In addition, we demonstrated the first THz spectroscopy application using a PTE sensor. The findings of this study, thermal/optical factor enhancement, and micro-sized CNT film processing technology can be used to improve the performance of all CNT-based photothermal devices, including PTE sensors and thermoelectric generators.

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Section: Introductionmentioning

confidence: 99%

Carbon nanotube-based, serially connected terahertz sensor with enhanced thermal and optical efficiencies

Suzuki

Takida

Kawano

et al. 2022

Science and Technology of Advanced Materials

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“…Currently, methods used to determine the extent of tumor resection have inherent limitations. [27][28][29] However, THI offers a promising solution to identify the extent of tumor resection and metastatic SNLs during surgery and reduce the number of reoperations. Fitzgerald was the first researcher who detected breast tumors by THI and determined the exact location and shape of the tumor by imaging terahertz and showed that THI could distinguish healthy and cancerous breast tissues.…”

Section: Breast Cancermentioning

confidence: 99%

A Review of Feasible Applications of THz Waves in Medical Diagnostics and Treatments

et al. 2021

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Introduction: Terahertz (THz) waves with frequencies in the range of 0.1 to 10 THz are electromagnetic radiation with growing applications in various fields of science and technology. Attractive features of this radiation have brought out many novel possibilities for medical diagnostics and treatments with considerable advantages compared to other conventional methods. Methods: In this paper, we present a review of more recent reports on practical applications of THz radiation for diagnostic, biosensing and clinical treatments. The review includes the diagnosis of breast, skin, mouth, cervical, lungs, small intestine, prostate, colon, and stomach cancers, the evaluation of biomolecules, the detection of genetic mutations, the determination of burn depth, the diagnosis of tooth decay, diabetes, and emotional-psychological states, the evaluation of corneal water to diagnose visual diseases, and wound healing monitoring. Further, it embraces the use of THz therapy in reducing the size of the tumor, treating skin cancer, and healing burn wounds, cardiovascular disease, corneal epithelium, angina, and THz heating. Results: This review has emphasized the capabilities of THz waves as a novel tool for future clinical diagnostics and treatments. Conclusion: The paper provides a comprehensive understanding of the feasible potential application of THz waves for clinical purposes and its advantages in comparison with other conventional tools.

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“…The recent developments in THz imaging technology and its application for breast tumor identification is reported by Wang ( 2021 ) and exploited the potential application of THz imaging and spectroscopy systems for breast cancer detection, with a discussion of the breast tissue’s dielectric properties within THz range, THz radiation sources, and imaging with spectroscopy. The methods for improvement of data collection, processing and resolution based on chemometrics are summarized.…”

Section: Introductionmentioning

confidence: 99%

Advances in terahertz technology for cancer detection applications

Gezimati

Singh

2022

Opt Quant Electron

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Currently, there is an increasing demand for the diagnostic techniques that provide functional and morphological information with early cancer detection capability. Novel modern medical imaging systems driven by the recent advancements in technology such as terahertz (THz) and infrared radiation-based imaging technologies which are complementary to conventional modalities are being developed, investigated, and validated. The THz cancer imaging techniques offer novel opportunities for label free, non-ionizing, non-invasive and early cancer detection. The observed image contrast in THz cancer imaging studies has been mostly attributed to higher refractive index, absorption coefficient and dielectric properties in cancer tissue than that in the normal tissue due the local increase of the water molecule content in tissue and increased blood supply to the cancer affected tissue. Additional image contrast parameters and cancer biomarkers that have been reported to contribute to THz image contrast include cell structural changes, molecular density, interactions between agents (e.g., contrast agents and embedding agents) and biological tissue as well as tissue substances like proteins, fiber and fat etc. In this paper, we have presented a systematic and comprehensive review of the advancements in the technological development of THz technology for cancer imaging applications. Initially, the fundamentals principles and techniques for THz radiation generation and detection, imaging and spectroscopy are introduced. Further, the application of THz imaging for detection of various cancers tissues are presented, with more focus on the in vivo imaging of skin cancer. The data processing techniques for THz data are briefly discussed. Also, we identify the advantages and existing challenges in THz based cancer detection and report the performance improvement techniques. The recent advancements towards THz systems which are optimized and miniaturized are also reported. Finally, the integration of THz systems with artificial intelligent (AI), internet of things (IoT), cloud computing, big data analytics, robotics etc. for more sophisticated systems is proposed. This will facilitate the large-scale clinical applications of THz for smart and connected next generation healthcare systems and provide a roadmap for future research.

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Terahertz Imaging for Breast Cancer Detection

Cited by 42 publications

References 90 publications

Carbon nanotube-based, serially connected terahertz sensor with enhanced thermal and optical efficiencies

Carbon nanotube-based, serially connected terahertz sensor with enhanced thermal and optical efficiencies

A Review of Feasible Applications of THz Waves in Medical Diagnostics and Treatments

Advances in terahertz technology for cancer detection applications

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