Terahertz metamaterial designs for capturing and detecting circulating tumor cells

Zhu, Mei; Ma, Shaoping; Wang, Jian; Su, Jisong; Liu, Ancheng

doi:10.1088/2053-1591/aafa54

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…In addition, the metamaterial can also be designed to trap circulating tumor cells (CTCs), which are rare in blood samples and hard to detect. An enrichment of CTC was realized through the metamaterial due to the mechanical trap, as shown in Figure 5b, and a 38 GHz resonant frequency was achieved [147].…”

Section: Microorganisms and Cellsmentioning

confidence: 99%

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Terahertz Metamaterials for Biosensing Applications: A Review

Zhang,

Lin,

Yuan

et al. 2023

Biosensors

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In recent decades, THz metamaterials have emerged as a promising technology for biosensing by extracting useful information (composition, structure and dynamics) of biological samples from the interaction between the THz wave and the biological samples. Advantages of biosensing with THz metamaterials include label-free and non-invasive detection with high sensitivity. In this review, we first summarize different THz sensing principles modulated by the metamaterial for bio-analyte detection. Then, we compare various resonance modes induced in the THz range for biosensing enhancement. In addition, non-conventional materials used in the THz metamaterial to improve the biosensing performance are evaluated. We categorize and review different types of bio-analyte detection using THz metamaterials. Finally, we discuss the future perspective of THz metamaterial in biosensing.

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Section: Microorganisms and Cellsmentioning

confidence: 99%

“…Figure5. Biosensing for different bio-analytes of (a) mRNA[137], (b) CTCs[147], (c) fungi/bacterial[140], and (d) yeast[141].…”

mentioning

confidence: 99%

Terahertz Metamaterials for Biosensing Applications: A Review

Zhang,

Lin,

Yuan

et al. 2023

Biosensors

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“…Surface plasmon resonance (SPR) is the phenomenon of EM wave coupling to an SPP wave. Regardless of technique, SPRs amplify and confine EM field and have been widely used in photonic devices for a variety of purposes, most notably biosensing [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

An ultrathin and flexible terahertz electromagnetically induced transparency-like metasurface based on asymmetric resonators

et al. 2023

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Terahertz (THz) electromagnetically induced transparency-like (EIT-like) metasurfaces have been extensively explored and frequently used for sensing, switching, slow light, and enhanced nonlinear effects. Reducing radiation and non-radiation losses in EIT-like systems contributes to increased electromagnetic (EM) field confinement, higher transmission peak magnitude, and Q-factor. This can be accomplished by the use of proper dielectric properties and engineering novel designs. Therefore, we fabricated a THz EIT-like metasurface based on asymmetric metallic resonators on an ultra-thin and flexible dielectric substrate. Because the quadruple mode is stimulated in a closed loop, an anti-parallel surface current forms, producing a transparency window with a transmission peak magnitude of 0.8 at 1.96 THz. To control the growing trend of EIT-like resonance, the structure was designed with four asymmetry levels. The effect of the substrate on the resonance response was also explored, and we demonstrated experimentally how the ultra-thin substrate and the metasurface asymmetric novel pattern contributed to higher transmission and lower loss.

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“…A large knowledgebase has been created thanks to the recent studies of metamaterials [7][8][9]. Thus, the significance of the MMF for dealing with biological challenges [10][11][12] is clearly observed. Sensing, chemical and biomedical applications are possible thanks to the recent studies of electromagnetic radiation in THz frequency range.…”

Section: Introductionmentioning

confidence: 99%

The Discrete Analysis of the Tissue Biopsy Images With Metamaterial Formalization: Identifying Tumor Locus

Gric

Sokolovski

Alekseev

et al. 2021

IEEE J. Select. Topics Quantum Electron.

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Herein, we develop an enhanced and automated methodology for detection of the tumour cells in fixed biopsy samples. Metamaterial formalism (MMF) approach allowing recognition of tumour areas in tissue samples is enhanced by providing an advanced technique to digitize mouse biopsy images. Thus, a colour-based segmentation technique based on the Kmeans clustering method is used allowing for a precise segmentation of the cells composing the biological tissue sample. Errors occurring at the tissue digitization steps are detected by applying MMF. Doing so, we end up with the robust, fully automated approach with no needs of the human intervention, ready for the clinical applications. The proposed methodology consists of three major steps, i. e. digitization of the biopsy image, analysis of the biopsy image, modelling of the disordered metamaterial. It is worthwhile mentioning, that the technique under consideration allows for the cancer stage detection. Moreover, early stage cancer diagnosis is possible by applying MMF.

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Terahertz metamaterial designs for capturing and detecting circulating tumor cells

Cited by 7 publications

References 23 publications

Terahertz Metamaterials for Biosensing Applications: A Review

Terahertz Metamaterials for Biosensing Applications: A Review

An ultrathin and flexible terahertz electromagnetically induced transparency-like metasurface based on asymmetric resonators

The Discrete Analysis of the Tissue Biopsy Images With Metamaterial Formalization: Identifying Tumor Locus

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