Terahertz signatures and quantitative analysis of glucose anhydrate and monohydrate mixture

Hui, Yan; Fan, Wenhui; Xu, Chenggang; Liu, Lutao; Wang, Hanqi; Jiang, Xiaoqiang

doi:10.1016/j.saa.2021.119825

Cited by 16 publications

(7 citation statements)

References 44 publications

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“…Molecular packing of (C) glucose anhydrate and (D) glucose monohydrate. (E) THz signatures of glucose anhydrate, monohydrate and their mixture in 0.8–2.2 THz ( Yan et al, 2021 ). (F) Waterfall plot of THz absorption spectra of LC tetrahydrate at 25°C–100°C.…”

Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

“…High-concentration glucose can be used for the treatment of hyperkalemia and hypoglycemia. Yan et al studied the characteristic absorption peaks of anhydrous glucose and monohydrate glucose in the 0.8–2.2 THz band by THz-TDS technology ( Figures 6C–E ) ( Yan et al, 2021 ). Anhydrous glucose had a weak absorption peak at 1.27 THz, a strong absorption peak at 1.44 and 2.08 THz and a shoulder peak at 1.42 THz, which was almost coincident with 1.44 THz.…”

Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

See 1 more Smart Citation

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Huang

Deng

Xia

et al. 2023

Front. Bioeng. Biotechnol.

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Terahertz time-domain spectroscopy is an analytical method using terahertz time-domain pulses to study the physical and chemical properties of substances. It has strong potential for application in pharmaceutical analyses as an original non-destructive, efficient and convenient technology for spectral detection. This review briefly introduces the working principle of terahertz time-domain spectroscopy technology, focuses on the research achievements of this technology in analyses of chemical drugs, traditional Chinese medicine and biological drugs in the past decade. We also reveal the scientific feasibility of practical application of terahertz time-domain spectroscopy for pharmaceutical detection. Finally, we discuss the problems in practical application of terahertz time-domain spectroscopy technology, and the prospect of further development of this technology in pharmaceutical analyses. We hope that this review can provide a reference for application of terahertz time-domain spectroscopy technology in pharmaceutical analyses in the future.

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Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Huang

Deng

Xia

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Terahertz (THz) wave has great potential for substance detection by virtue of its broadband, low energy, and unique fingerprint spectrum [ 1 , 2 , 3 , 4 ]. However, with improvements in the required detection accuracy, the amount of reagents and the concentration of the test samples are often at the micro or even trace level, resulting in the traditional THz detection technology having problems such as weak response to substances and difficulty in capturing the spectrum.…”

Section: Introductionmentioning

confidence: 99%

Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor

Dong,

Wei,

Wei

et al. 2024

Sensors

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Quasi-bound state in the continuum (QBIC) can effectively enhance the interaction of terahertz (THz) wave with matter due to the tunable high-Q property, which has a strong potential application in the detection of low-concentration biological samples in the THz band. In this paper, a novel THz metamaterial sensor with a double-chain-separated resonant cavity structure based on QBIC is designed and fabricated. The process of excitation of the QBIC mode is verified and the structural parameters are optimized after considering the ohmic loss by simulations. The simulated refractive index sensitivity of the sensor is up to 544 GHz/RIU, much higher than those of recently reported THz metamaterial sensors. The sensitivity of the proposed metamaterial sensor is confirmed in an experiment by detecting low-concentration lithium citrate (LC) and bovine serum albumin (BSA) solutions. The limits of detection (LoDs) are obtained to be 0.0025 mg/mL (12 μM) for LC and 0.03125 mg/mL (0.47 μM) for BSA, respectively, both of which excel over most of the reported results in previous studies. These results indicate that the proposed THz metamaterial sensor has excellent sensing performances and can well be applied to the detection of low-concentration biological samples.

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“…Terahertz (THz) wave has great potential for substance detection by virtue of its broadband, low-energy, and unique fingerprint spectrum [1][2][3][4]. However, with the improvement of the required detection accuracy, the amount of reagents and the concentration of the test samples are often at the micro-or even trace level, resulting in the traditional THz detection technology having problems such as weak response to substances and difficulty in capturing the spectrum.…”

Section: Introductionmentioning

confidence: 99%

Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor

Dong,

Wei,

Wei

et al. 2024

Preprint

View full text Add to dashboard Cite

Quasi-bound state in the continuum (QBIC) can effectively enhance the interaction of terahertz (THz) wave with matters due to the tunable high-Q property, which has a strong potential application in detection of low-concentration biological samples in the THz band. In this paper, a novel THz metamaterial sensor with a double-chain separated resonant cavity structure based on QBIC is designed and fabricated. The process of excitation of the QBIC mode is verified and the structural parameters are optimized after considering the ohmic loss by simulations. The simulated refractive index sensitivity of the sensor is up to 544 GHz/RIU, much higher than those of recently reported THz metamaterial sensors. Sensing sensitivity of the proposed metamaterial sensor is confirmed in experiment by detecting low-concentration lithium citrate (LC) and bovine serum albumin (BSA) solutions. The limits of detection (LoDs) are obtained to be 0.0025 mg/mL (12 μM) for LC and 0.03125 mg/mL (0.47 μM) for BSA, respectively, both of which excel over most of reported results in previous studies. These results indicate that the proposed THz metamaterial sensor has excellent sensing performances and can well be applied to the detection of low concentration biological samples.

show abstract

Terahertz signatures and quantitative analysis of glucose anhydrate and monohydrate mixture

Cited by 16 publications

References 44 publications

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor

Detection of Low-Concentration Biological Samples Based on a QBIC Terahertz Metamaterial Sensor

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