Terahertz spectroscopy for bacterial detection: opportunities and challenges

Xiang, Yang; Yang, Ke; Luo, Yang; Fu, Weiling

doi:10.1007/s00253-016-7569-6

Cited by 63 publications

(29 citation statements)

References 58 publications

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“…[4,5,[7][8][9][10]15,[22][23][24] Nevertheless, a challenge still open is how to achieve reliable sensing when the measured sample amount is very small. These properties have given rise to a powerful research line, and indeed, the list of biological applications of THz is extensive and in continuous development so the interested reader is referred to some recent books and reviews devoted to the topic.…”

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confidence: 99%

“…These properties have given rise to a powerful research line, and indeed, the list of biological applications of THz is extensive and in continuous development so the interested reader is referred to some recent books and reviews devoted to the topic. [4,5,[7][8][9][10]15,[22][23][24] Nevertheless, a challenge still open is how to achieve reliable sensing when the measured sample amount is very small. [25] In this situation, the substance under test simply does not interact sufficiently with the electromagnetic waves inducing negligible changes in the response and making detection extremely difficult or even impossible with conventional techniques.…”

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confidence: 99%

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Terahertz Sensing Based on Metasurfaces

Beruete

Jáuregui-López

2019

Advanced Optical Materials

282

113

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The terahertz (THz) band has very attractive characteristics for sensing and biosensing applications, due to some interesting features such as being a non‐ionizing radiation, very sensitive to weak interactions, thus, complementing typical spectroscopy systems in the infrared. However, a fundamental drawback is its relatively long wavelength (10–1000 µm) which makes it blind to small features, hindering seriously both thin‐film and biological sensing. Recently, new ways to overcome this limitation have become possible thanks to the advent of metasurfaces. These artificial structures are planar screens usually made of periodic metallic resonators and whose electromagnetic response can be controlled at will by design. This design freedom allows metasurfaces to surpass the restrictions of classical THz spectroscopy, by creating fine details comparable to the size of the thin films or microorganisms under test. The strong field concentration near these small metasurface details at resonance makes them highly sensitive to tiny variations in the nearby environment, allowing for an enhanced detection more accurate than classical THz spectroscopy. The main advances in THz metasurface sensors from a historical as well as application‐oriented perspective are summarized. The focus is put mainly on thin‐film and biological sensors, with an aim to cover the most recent advances in the topic.

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confidence: 99%

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Terahertz Sensing Based on Metasurfaces

Beruete

Jáuregui-López

2019

Advanced Optical Materials

282

113

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“…Molecular methods are also complex, but are fast and have LOD of several genome equivalents. Mass spectroscopy techniques are reagent‐free, very fast, and simple, with an LOD of between 10 5 and 10 6 CFU/mL (Yang, Yang, Luo, & Fu, ). None of these methods can detect microorganisms inside a package or differentiate between dead and living bacteria.…”

Section: Food Applications Of Thz Spectroscopy and Imagingmentioning

confidence: 99%

A Comprehensive Review on Food Applications of Terahertz Spectroscopy and Imaging

Afsah‐Hejri

Hajeb

Ara

et al. 2019

Comp Rev Food Sci Food Safe

222

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Food product safety is a public health concern. Most of the food safety analytical and detection methods are expensive, labor intensive, and time consuming. A safe, rapid, reliable, and nondestructive detection method is needed to assure consumers that food products are safe to consume. Terahertz (THz) radiation, which has properties of both microwave and infrared, can penetrate and interact with many commonly used materials. Owing to the technological developments in sources and detectors, THz spectroscopic imaging has transitioned from a laboratory‐scale technique into a versatile imaging tool with many practical applications. In recent years, THz imaging has been shown to have great potential as an emerging nondestructive tool for food inspection. THz spectroscopy provides qualitative and quantitative information about food samples. The main applications of THz in food industries include detection of moisture, foreign bodies, inspection, and quality control. Other applications of THz technology in the food industry include detection of harmful compounds, antibiotics, and microorganisms. THz spectroscopy is a great tool for characterization of carbohydrates, amino acids, fatty acids, and vitamins. Despite its potential applications, THz technology has some limitations, such as limited penetration, scattering effect, limited sensitivity, and low limit of detection. THz technology is still expensive, and there is no available THz database library for food compounds. The scanning speed needs to be improved in the future generations of THz systems. Although many technological aspects need to be improved, THz technology has already been established in the food industry as a powerful tool with great detection and quantification ability. This paper reviews various applications of THz spectroscopy and imaging in the food industry.

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“…Enhancement (E) 0 > 100 nm 100 -10 nm 10 -1 nm 10 1 10 2 10 3 < 1 nm w=1 m E=300 [39] w=100 nm E=1000 [89] w=70 nm E=1000 [34] w=20 nm E=1200 [36] w=2 nm E=1200 [21] w=9 nm E=180 [37] w=1.5 nm E=2000 [16] w=10 m E=30 [33] is a non-invasive and one of the most widely used technique in biosensing 80,[83][84][85][86][87] because the THz-spectra are less energetic (about a few milli-electronvolts) lies in the characteristic vibration frequency regime of proteins and DNA molecules. Terahertz nanoantennas provide us label-free and ultra-sensitive sensing of molecules 88,89 and biomolecules 37,81,[90][91][92][93][94] as the nanoantennas focus the THz waves into an extremely confined volume where we can place our analytes at very low concentrations.…”

Section: Thz-fieldmentioning

confidence: 99%

Nanoantenna enhanced terahertz interaction of biomolecules

Adak

Tripathi

2019

Analyst

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Terahertz time-domain spectroscopy (THz-TDS) is a non-invasive, non-contact and label-free technique for biological and chemical sensing as THz-spectra is less energetic and lies in the characteristic vibration frequency regime of proteins and DNA molecules. However, THz-TDS is less sensitive for detection of micro-organisms of size equal to or less than λ/100 (where, λ is wavelength of incident THz wave) and, molecules in extremely low concentrated solutions (like, a few femtomolar). After successful high-throughput fabrication of nanostructures, nanoantennas and metamaterials were found to be indispensable in enhancing the sensitivity of conventional THz-TDS. These nanostructures lead to strong THz field enhancement which when in resonance with absorption spectrum of absorptive molecules, causing significant changes in the magnitude of the transmission spectrum, therefore, enhancing the sensitivity and allowing detection of molecules and biomaterials in extremely low concentrated solutions. Hereby, we review the recent developments in ultra-sensitive and selective nanogap biosensors. We have also provided an in-depth review of various high-throughput nanofabrication techniques. We also discussed the physics behind the field enhancements in sub-skin depth as well as sub-nanometer sized nanogaps. We introduce finite-difference time-domain (FDTD) and molecular dynamics (MD) simulations tools to study THz biomolecular interactions. Finally, we provide a comprehensive account of nanoantenna enhanced sensing of viruses (like, H1N1) and biomolecules such as artificial sweeteners which are addictive and carcinogenic. CONTENTS

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Terahertz spectroscopy for bacterial detection: opportunities and challenges

Cited by 63 publications

References 58 publications

Terahertz Sensing Based on Metasurfaces

Terahertz Sensing Based on Metasurfaces

A Comprehensive Review on Food Applications of Terahertz Spectroscopy and Imaging

Nanoantenna enhanced terahertz interaction of biomolecules

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