Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis

Abstract

Perioperative administration of teriparatide is more effective than that of low-dose bisphosphonates in preventing complications and maintaining fusion rates in osteoporotic Japanese females with spinal deformities undergoing surgery.

Effect of Bisphosphonates or Teriparatide on Mechanical Complications after Posterior Instrumented Fusion for Osteoporotic Vertebral Fracture: A Multi-center Retrospective Study

“…found that adjacent vertebral fracture, implant failure, and fusion failure rates were signi cantly lower in their TP group than in their BP group [16]. In accordance with these studies, our result also suggested that it may be considered useful for reducing mechanical complications and pseudoarthrosis in surgically treated case of OVF.…”

“…Previous studies have demonstrated the superiority of TP over BP in patients who have undergone conservative treatment for OVF according to bone union rates [13][14][15]. Other studies have shown the positive effects of TP on bony fusion after spinal fusion or correction surgery [16][17][18][19][20][21]. TP has bone anabolic ability and can reduce the chance of screw loosening, and so the use of TP may effectively enhance spinal fusion and reduce implant failure and/ or subsequent vertebral fracture in comparison with surgery [16][17][18][19][20][21].…”

“…Other studies have shown the positive effects of TP on bony fusion after spinal fusion or correction surgery [16][17][18][19][20][21]. TP has bone anabolic ability and can reduce the chance of screw loosening, and so the use of TP may effectively enhance spinal fusion and reduce implant failure and/ or subsequent vertebral fracture in comparison with surgery [16][17][18][19][20][21]. However, there is limited literature on the relationship between administration of these agents and mechanical complications after posterior fusion surgery for OVF.…”

Limitations and complications of minimally invasive spinal surgery in adult deformity

“…Perioperative treatment with recombinant human parathyroid hormone (teriparatide/Forteo) has been useful for preoperative augmentation of bone quality, with good outcomes in patients with poor bone mineral density scores. This drug not only has antiresorptive but also osteoinductive properties that quickly re-establish good bone quality in patients requiring major spinal deformity surgery (7)(8)(9)(10)(11)(12).…”

Effect of Bisphosphonates or Teriparatide on Mechanical Complications after Posterior Instrumented Fusion for Osteoporotic Vertebral Fracture: A Multi-center Retrospective Study

“…Previous studies have demonstrated the superiority of TP over BP in patients who have undergone conservative treatment for OVF according to bone union rates [12][13][14]. Other studies have shown the positive effects of TP on bony fusion after spinal fusion or correction surgery [15][16][17][18][19][20]. TP has bone anabolic ability and can reduce the chance of screw loosening, and so the use of BP may effectively enhance spinal fusion and reduce implant failure and/ or subsequent vertebral fracture in comparison with surgery [16,19,20].…”