The resistance of resin-reconstructed cores is crucial for the durability of dental restorations. The study aimed to compare the tensile strength of resin cores retained by interdentinal pins and adhesive agents. Forty human first premolars were used, divided into four groups of 10, utilizing screwed interdentinal pins, cemented interdentinal pins, and fifth and sixth-generation adhesive agents. The results indicated that cemented interdentinal pins combined with sixth-generation adhesive agents provided the highest tensile strength (22.77 MPa), followed by total-etch adhesives (20.94 MPa), self-etch adhesives (16.46 MPa), and screwed interdentinal pins (13.44 MPa). It is concluded that the use of cemented interdentinal pins and advanced adhesive agents is superior, suggesting the need for an interdisciplinary approach to improve the effectiveness of dental restorations