Terpene toxicity and oxidative stress

Ağuş, Hızlan Hıncal

doi:10.1016/b978-0-12-819092-0.00004-2

Cited by 36 publications

(25 citation statements)

References 69 publications

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“…Most of the terpenoids have shown some cytotoxic effects primarily on vital organs, such as the liver, lungs, kidney, and neuronal tissues at higher concentrations when used in pure form. These cytotoxic studies have shown that these terpenoids exert adverse effects by disrupting plasma membrane, producing ROS, impairing mitochondrial function, and/or causing lipid peroxidation (Agus 2021 ). These specialized metabolites mainly exhibit hepatotoxicity as the reactive metabolites and ROS are formed during their metabolism in the liver (Zárybnický et al 2018 ).…”

Section: Potential Adverse Health Effects Of Specialized Metabolites Present In Ocimum Speciesmentioning

confidence: 99%

A glance at the chemodiversity of Ocimum species: Trends, implications, and strategies for the quality and yield improvement of essential oil

2021

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Ocimum species represent commercially important medicinal and aromatic plants. The essential oil biosynthesized by Ocimum species is enriched with specialized metabolites specifically, terpenoids and phenylpropanoids. Interestingly, various Ocimum species are known to exhibit diverse chemical profiles, and this chemical diversity has been at the center of many studies to identify commercially important chemotypes. Here, we present various chemotypes from the Ocimum species and emphasize trends, implications, and strategies for the quality and yield improvement of essential oil. Globally, many Ocimum species have been analyzed for their essential oil composition in over 50 countries. Asia represents the highest number of chemotypes, followed by Africa, South America, and Europe. Ocimum basilicum L. has been the most widespread and well-studied species, followed by O . gratissimum L., O . tenuiflorum L., O . canum Sims, O . americanum and O . kilimandscharicum Gürke. Moreover, various molecular reasons, benefits, adverse health effects and mechanisms behind this vast chemodiversity have been discussed. Different strategies of plant breeding, metabolic engineering, transgenic, and tissue-culture, along with anatomical modifications, are surveyed to enhance specific chemotypic profiles and essential oil yield in numerous Ocimum species. Consequently, chemical characterization of the essential oil obtained from Ocimum species has become indispensable for its proper utilization . The present chemodiversity knowledge from Ocimum species will help to exploit various applications in the industrial, agriculture, biopharmaceutical, and food sectors. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09767-z.

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Section: Potential Adverse Health Effects Of Specialized Metabolites Present In Ocimum Speciesmentioning

confidence: 99%

A glance at the chemodiversity of Ocimum species: Trends, implications, and strategies for the quality and yield improvement of essential oil

2021

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“…In an animal toxicology study, it was shown to cause up to a fourfold increase in serum aspartate aminotransferase enzyme levels and a twofold decrease in body weight in animals when fed with 5% linalool. An increase in this enzyme can lead to myocardial necrosis, liver damage, skeletal muscle damage, or pancreatitis [ 7 ]. Linalool (40.43%) was the dominant constituent of the EO from M. × piperita f. citrata ( M3 ), which is consistent with the literature [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…Most terpenes are classified as safe natural chemicals. Some of the biological properties of monoterpenes and sesquiterpenes, such as antifungal and antimicrobial, have been shown to be the result of their disruption of the cell membrane or cytoplasmic structures as a consequence of oxidative stress, while others can assist radical scavengers and are also known as antioxidant molecules [ 2 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Headspace Solid-Phase Micro-Extraction Versus Hydrodistillation of Volatile Compounds from Leaves of Cultivated Mentha Taxa: Markers of Safe Chemotypes

et al. 2022

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Various mint taxa are widely cultivated and are used not only for medicinal purposes but also in cosmetic and industrial applications. The development of new varieties or cultivars of mint generates difficulties in their correct identification and safe use. Volatile organic compounds (VOCs) from the leaves of seven different taxa of the genus Mentha obtained by hydrodistillation (HD) and headspace solid-phase microextraction (HS-SPME) were analyzed using gas chromatography–mass spectrometry (GC-MS). Principal component analysis (PCA) was also performed. Comparative GC-MS analysis of the obtained extracts showed similarity in the major compounds. PCA data allowed the separation of two groups of chemotypes among the analyzed mints, characterized by the abundance of piperitenone oxide and carvone. Two out of seven analyzed taxa were not previously examined for VOC profile, one was examined only for patent application purposes, and six out of seven were investigated for the first time using the HS-SPME technique. The presented analysis provides new data on the abundance and qualitative characterization of VOCs in the studied mint plants and on the safety of their use, related to the possibility of the presence of potentially toxic components. HS-SPME is a valuable method to extend the characterization of the VOC profile obtained by hydrodistillation.

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“…Ribeiro et al [ 106 ] reported that terpilonene showed low acute toxicity by residual contact against the mite Tetranychus urticae and was less efficient than other monoterpenes. However, Agus [ 107 ] stated that terpinolene is among the most toxic monoterpenes along with α-terpineol and linalool. According to Scherf et al [ 108 ], terpinolene was toxic to Drosophila melanogaster , with an LC 50 of 34.60 μL.L −1 at 12 h of exposure.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Profile, Preliminary Toxicity, and Antioxidant Capacity of the Essential Oils of Myrciaria floribunda (H. West ex Willd.) O. Berg. and Myrcia sylvatica (G. Mey) DC. (Myrtaceae)

et al. 2022

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The essential oils (EOs) of Myrciaria floribunda (Mflo) and Myrcia sylvatica (Msyl) (Myrtaceae) were obtained by hydrodistillation. The analysis of volatile constituents was performed by GC/MS. Preliminary toxicity was assessed on Artemia salina Leach. The antioxidant capacity was measured by the ABTS•+ and DPPH• radical inhibitory activities. The results indicate that the Mflo EO had the highest yield (1.02%), and its chemical profile was characterized by high levels of hydrocarbon (65.83%) and oxygenated (25.74%) monoterpenes, especially 1,8-cineole (23.30%), terpinolene (22.23%) and α-phellandrene (22.19%). Regarding the Msyl EO, only hydrocarbon (51.60%) and oxygenated (46.52%) sesquiterpenes were identified in the sample, with (Z)-α-trans-bergamotene (24.57%), α-sinensal (13.44%), and (Z)-α-bisabolene (8.33%) at higher levels. The EO of Mflo exhibited moderate toxicity against A. salina (LC50 = 82.96 ± 5.20 µg.mL−1), while the EO of Msyl was classified as highly toxic (LC50 = 2.74 ± 0.50 µg.mL−1). In addition, relative to Trolox, the EOs of Mflo and Msyl showed significant inhibitory effects (p < 0.0001) against the DPPH• radical. This study contributes to the expansion of chemical and biological knowledge on the EOs of Myrtaceae species from the Amazon region.

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Terpene toxicity and oxidative stress

Cited by 36 publications

References 69 publications

A glance at the chemodiversity of Ocimum species: Trends, implications, and strategies for the quality and yield improvement of essential oil

A glance at the chemodiversity of Ocimum species: Trends, implications, and strategies for the quality and yield improvement of essential oil

Headspace Solid-Phase Micro-Extraction Versus Hydrodistillation of Volatile Compounds from Leaves of Cultivated Mentha Taxa: Markers of Safe Chemotypes

Phytochemical Profile, Preliminary Toxicity, and Antioxidant Capacity of the Essential Oils of Myrciaria floribunda (H. West ex Willd.) O. Berg. and Myrcia sylvatica (G. Mey) DC. (Myrtaceae)

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