Terpenoids from the stem bark of Azadirachta indica

A new cytotoxic and larvicidal himachalenoid, rosanoids and other constituents ofHugonia busseana

“…Vacuum liquid chromatography (VLC) of fractions 8 and 9 of the ethanol extract yielded white crystals of hugorosediol (3) and the di-podocarpanoid hugonone B which were previously isolated from the root barks of H. castaneifolia [5], and an inseparable mixture of the podocarpane derivatives 12-methoxy-13-methylpodocarpa-8,11,13-trien-3,7-dione and 12-methoxy-13-methylpodocarpa-1,8,11,13,-tetraen-3,7-dione, in the ratio 4 : 1, both of which are related to nimbione which was previously obtained from the stem barks of Azadirachta indica [12,13].…”

Antioxidative 7-Oxodehydropodocarpane-Type Trinorditerpenes from the Bark ofTaiwania cryptomerioides

“…One of carbonyl groups was situated at C-3 (d C 214.0) which was revealed from the low-field signals of H-18 (d 1.10), H-19 (d 1. 16) and H-20 (d 1.36) [2], [4]. Further evidence was obtained from HMBC correlations between C-3 and H-18 and H-19.…”

Azadirachta indica

“…From the bark/stem/trunk were isolated branched chain paraffi n alcohol, C 26 H 54 O, nimbosterol, sugiol and a new ketophenol, nimbiol, with molecular formula of C 18 H 24 O 2 ; nimbosterol was identifi ed as β-sitosterol (Sengupta et al 1960a ); desacetylnimbin (Narayanan and Iyer 1967 ); two meliacins, nimbolins A and B, as well as fraxinellone and gedunin from trunk wood (Ekong et al 1969 ); pentanortriterpenoids, nimbinene and 6-deacetylnimbinene (Kraus and Cramer 1981b ); two isomeric diterpenoids, nimbione and nimbinone, and a new ring C-seco-tetranortriterpenoid, isonimbinolide (Ara et al 1988 ); margosinone and margosinolone, two new polyacetate derivatives (Ara et al 1989d ); three tricyclic diterpenoids, margolone, margolonone and isomargolonone (Ara et al 1989e ); two diterpenoids, nimbionone and nimbionol, with structures determined as 12-hydroxy-13-methoxypodocarpa-8,11,13-trien-3,7-dione and 3,12-dihydroxy-13-methoxypodocarpa-8,11,13-trien-7-one, respectively (Siddiqui et al 1988a ); gedunin, an antimalarial agent (Khalid et al 1989 ); two isomeric diterpenoids named nimbonone and nimbonolone with structures 12-ethyl-13-methoxy podocarpa-8,11,13-trien-7-one and 12-ethyl-13-methoxy podocarpa-8,11,13-trien-3-one, respectively, along with methyl grevillate (Ara et al 1989b ); gallocatechin, catechin, epigallocatechin and epicatechin (van der Nat et al 1991b ); and a limonoid, 12-hydroxyamoorastatone, along with two known limonoids, hydroxyamoorastatin-12 and 12-acetoxyam-oorastatin (Ahn et al 1994 ). Two peptidoglycans, polymers NB-I and NB-II, were isolated from the crude bark extract (van der Nat et al 1989 ).…”