“…The readily formed bond between a noble metal and thiol makes it convenient to generate a self-assembled monolayer (SAM) on the surface of certain electrodes. 31,32 In the field of electrochemical DNA sensors, a strategy with a mixed SAM of an oligonucleotide probe and a redox mediator was proposed for direct and reagentless DNA detection. 33,34 Similarly, if a mixed SAM containing both Fc residues and GOD is constructed, their distribution could be practically restricted within the monolayer, and the electron transfer mediation between them could be enhanced.…”