TERT polymorphisms rs2853669, rs2736100, rs7726159 and rs10069690 and the risk of non-Hodgkin’s lymphoma in ethnical Russians

Abstract

Telomere length could be one of the risk factors for non-Hodgkin's lymphoma. We studied the association of four functional single nucleotide polymorphisms rs2853669, rs2736100, rs7726159 and rs10069690 in the TERT gene that encodes telomerase reverse transcriptase with the risk of non-Hodgkin's lymphoma in ethnical Russians. The case group consisted of 344 patients, including 139 patients with diffuse large B-cell lymphoma and 77 patients with small lymphocytic lymphoma/chronic lymphocytic leukemia. The control group comprised 893 individuals with no history of cancer. Genotyping was carried out by real-time PCR allelic discrimination with TaqMan probes. None of the studied polymorphisms and haplotypes showed statistically significant association with non-Hodgkin's lymphoma and its subtypes diffuse large B-cell lymphoma and small lymphocytic lymphoma/chronic lymphocytic leukemia. Our results provide evidence that tested polymorphisms do not influence the risk of non-Hodgkin's lymphoma in Russian population.

TERT rs10069690 polymorphism and cancers risk: A meta‐analysis

“…The 45 studies included nine on breast cancer (Garcia‐Closas et al, ; Haiman et al, ; Huo et al, ; Michailidou et al, , ; Palmer et al, ; Purrington et al, ) and, six on ovarian cancer (Bojesen et al, ; Earp et al, ; Kuchenbaecker et al, ; Lee et al, ; Phelan et al, ; Terry et al, ); five on lung cancer (Gao et al, ; Landi et al, ; Wang et al, ; Ye et al, ; Zhao et al, ). two each on glioma (Melin et al, ; Zhao et al, ), thyroid cancer (Gong et al, ; Gudmundsson et al, ), pancreatic cancer (Campa, Rizzato, et al, ; Petersen et al, ), prostate cancer (Panagiotou et al, ; Schumacher et al, ), colorectal cancer (Li et al, ; Pellatt, Wolff, Herrick, Lundgreen, & Slattery, ), RCC (Martino et al, ; Wu, Yan, et al, ), and leukemia (Sheng et al, ; Speedy et al, ); and one each on endometrial cancer (Prescott, McGrath, Lee, Buring, & De Vivo, ), bladder cancer (Rothman et al, ), testicular germ cell tumor (TGCTs) (Schumacher et al, ), melanoma (Llorca‐Cardenosa et al, ), multiple myeloma (Campa, Martino, et al, ), gastrointestinal stromal tumors (GISTs) (Zhang et al, ), non‐Hodgkin's lymphoma (NHL), diffuse Large B‐cell lymphoma (DLBCL), small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) (Shadrina et al, ), nasopharyngeal carcinoma (NPC) (Zhang et al, ), gastric cancer (Duan et al, ), esophageal cancer (Wu, Yan, et al, ), gastric cardia adenocarcinoma (GCA) (Zhang et al, ), hepatocellular carcinoma (HCC) (Zhang et al, ). One study focused on Caucasians (Prescott et al, ); two studies focused on Africans (Huo et al, ; Long et al, ); three studies on African‐Americans (Bojesen et al, ; Haiman et al, ; Palmer et al, ), 16 studies on Asians (Bojesen et al, ; Duan et al, ; Gao et al,…”

“…two each on glioma (Melin et al, ; Zhao et al, ), thyroid cancer (Gong et al, ; Gudmundsson et al, ), pancreatic cancer (Campa, Rizzato, et al, ; Petersen et al, ), prostate cancer (Panagiotou et al, ; Schumacher et al, ), colorectal cancer (Li et al, ; Pellatt, Wolff, Herrick, Lundgreen, & Slattery, ), RCC (Martino et al, ; Wu, Yan, et al, ), and leukemia (Sheng et al, ; Speedy et al, ); and one each on endometrial cancer (Prescott, McGrath, Lee, Buring, & De Vivo, ), bladder cancer (Rothman et al, ), testicular germ cell tumor (TGCTs) (Schumacher et al, ), melanoma (Llorca‐Cardenosa et al, ), multiple myeloma (Campa, Martino, et al, ), gastrointestinal stromal tumors (GISTs) (Zhang et al, ), non‐Hodgkin's lymphoma (NHL), diffuse Large B‐cell lymphoma (DLBCL), small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) (Shadrina et al, ), nasopharyngeal carcinoma (NPC) (Zhang et al, ), gastric cancer (Duan et al, ), esophageal cancer (Wu, Yan, et al, ), gastric cardia adenocarcinoma (GCA) (Zhang et al, ), hepatocellular carcinoma (HCC) (Zhang et al, ). One study focused on Caucasians (Prescott et al, ); two studies focused on Africans (Huo et al, ; Long et al, ); three studies on African‐Americans (Bojesen et al, ; Haiman et al, ; Palmer et al, ), 16 studies on Asians (Bojesen et al, ; Duan et al, ; Gao et al, ; Gong et al, ; Li et al, ; Sheng et al, ; Wang et al, ; Wu, Yan, et al, ; Wu, Zhu, et al, ; Zhang et al, ; Ye et al, ; Zhang et al, ; Zhang et al, ; Zhang et al, ; Zhao et al, ; Zhao et al, ); twenty studies on European (Campa, Martino, et al, ; Campa, Rizzato, et al, ; Earp et al, ; Garcia‐Closas et al, ; Gudmundsson et al, ; Haiman et al,…”