Tertiary Hyperparathyroidism With Renal Osteodystrophy on 18F-Fluorocholine PET/CT

Broos, Wouter A M; Wondergem, Maurits; Zant, Friso M. van der; Knol, Remco J.J.

doi:10.1097/rlu.0000000000002230

Cited by 6 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 F-choline-avid degenerative changes were observed in four patients, a 18 F-choline-avid osteoid osteoma in one patient and vertebral hemangiomas with decreased 18 F-choline uptake in three patients. In two patients, both diagnosed with tertiary hyperparathyroidism, a diffusely increased uptake of 18 F-choline was noticed in the skeleton, accompanied with diffuse sclerosis on CT. 8 …”

Section: Resultsmentioning

confidence: 99%

Incidental Findings on 18F-Fluorocholine PET/CT for Parathyroid Imaging

et al. 2022

Self Cite

View full text Add to dashboard Cite

Introduction 18F-choline positron emission tomography/computed tomography (PET/CT) is an upcoming imaging technique for the localization of hyperfunctioning parathyroid glands. However, 18F-choline is a nonspecific tracer that also accumulates in malignancies, inflammatory lesions, and several other benign abnormalities. The aim of this study was to determine the occurrence and relevance of incidental findings on 18F-choline PET/CT for parathyroid localization. Materials and Methods 18F-choline PET/CTs performed in our center for parathyroid localization from 2015 to 2019 were reviewed. Abnormal uptake of 18F-choline, with or without anatomical substrate on the co-registered low-dose CT and also incidental findings on CT without increased 18F-choline uptake were recorded. Each finding was correlated with follow-up data from the electronic medical records. Results A total of 388 18F-choline PET/CTs were reviewed, with 247 incidental findings detected in 226 patients (58%): 82 18F-choline positive findings with corresponding pathology on CT, 16 without CT substrate, and 149 18F-choline negative abnormalities on CT. Malignant lesions were detected in 10/388 patients (2.6%). Of all 98 detected 18F-choline positive lesions, 15 were malignant (15.3%), concerning 4 metastases and 11 primary malignancies: breast carcinoma (n = 7), lung carcinoma (n = 2), thyroid carcinoma (n = 1), and skin melanoma (n = 1). Conclusion Clinically relevant incidental findings were observed in a substantial number of patients. In 15.3% of the incidental 18F-choline positive findings, the lesions were malignant. These data contribute to better knowledge of 18F-choline distribution, enhance interpretation of 18F-choline PET/CT, and guide follow-up of incidental findings. Attention should especially be paid to breast lesions in this particular patient group with hyperparathyroidism in which women are typically over-represented.

show abstract

Section: Resultsmentioning

confidence: 99%

Incidental Findings on 18F-Fluorocholine PET/CT for Parathyroid Imaging

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…18 F-NaF PET/CT imaging of parathyroid adenoma with hyperparathyroidism and osteitis fibrosa cystica has been reported [ 6 ]. Moreover, visualization of ROD has been described with the use of 18 F-Fluorocholine, a tracer for parathyroid imaging [ 7 ]. To our knowledge, the simultaneous combination of 18 F-Fluorocholine PET/CT imaging and 18 F-NaF PET/CT whole-body bone imaging in the diagnosis of high turnover ROD due to SHPT has not been reported previously.…”

Section: Discussionmentioning

confidence: 99%

High turnover renal osteodystrophy due to secondary hyperparathyroidism diagnosed by ¹⁸F-Fluorocholine combined with ¹⁸F-NaF PET/CT

Xiong

Chen

et al. 2021

Renal Failure

View full text Add to dashboard Cite

“…In recent years, many studies have been performed on the use of 18 F-FCH PET/CT in primary hyperparathyroidism with promising results [ 7 , 8 ]. However, its performance in secondary and tertiary hyperparathyroidism is limited [ 9 , 10 ]. Our report showed how nuclear medicine imaging can provide effective and complete diagnostic information, essential for HPT patient management.…”

mentioning

confidence: 99%

18F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy

et al. 2020

View full text Add to dashboard Cite

Tertiary hyperparathyroidism (HPT) is a metabolic disorder characterized by the semi-autonomous hypersecretion of parathyroid hormone (PTH), leading to hypercalcemia. It can be the end result of persistent secondary hyperparathyroidism and is most commonly observed in patients with long-standing chronic kidney disease (CKD) and often after renal transplantation. Untreated HPT can lead to progressive bone disease, fibrocystic osteitis, and soft-tissue calcifications, along with other severe complications. In the 2009 Kidney Disease Improving Global Outcomes (KDIGO) guidelines, CKD-Mineral and Bone Disorder (CKD-MBD) is used to describe the broader clinical syndrome encompassing mineral, bone, and calcific cardiovascular abnormalities that develop as a complication of CKD. We report a 62-year-old female with a severe HPT evolved from advanced chronic kidney disease (stage 5D, KDIGO). Patient was evaluated with multimodality nuclear medicine functional imaging to assess hyperfunctioning parathyroid glands and bone lesions. Tc-99m-methoxyisobutylisonitrile (MIBI) dual-phase scintigraphy, Tc-99m-methylenediphosphonate (MDP) bone scan and 18F-Fluorocholine positron emission tomography/computed tomography (18F-FCH PET/CT) were performed before surgery.

show abstract

Tertiary Hyperparathyroidism With Renal Osteodystrophy on 18F-Fluorocholine PET/CT

Cited by 6 publications

References 8 publications

Incidental Findings on 18F-Fluorocholine PET/CT for Parathyroid Imaging

Incidental Findings on 18F-Fluorocholine PET/CT for Parathyroid Imaging

High turnover renal osteodystrophy due to secondary hyperparathyroidism diagnosed by ¹⁸F-Fluorocholine combined with ¹⁸F-NaF PET/CT

18F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy

Contact Info

Product

Resources

About

Tertiary Hyperparathyroidism With Renal Osteodystrophy on 18F-Fluorocholine PET/CT

Cited by 6 publications

References 8 publications

Incidental Findings on 18F-Fluorocholine PET/CT for Parathyroid Imaging

Incidental Findings on 18F-Fluorocholine PET/CT for Parathyroid Imaging

High turnover renal osteodystrophy due to secondary hyperparathyroidism diagnosed by 18F-Fluorocholine combined with 18F-NaF PET/CT

18F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy

Contact Info

Product

Resources

About

High turnover renal osteodystrophy due to secondary hyperparathyroidism diagnosed by ¹⁸F-Fluorocholine combined with ¹⁸F-NaF PET/CT