Tesla Valve Microfluidics: The Rise of Forgotten Technology

Purwidyantri, Agnes; Prabowo, Briliant Adhi

doi:10.3390/chemosensors11040256

Cited by 13 publications

(3 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though Tesla valve-inspired designs have gained some traction in the microfluidics field (reviewed in (Purwidyantri & Prabowo, 2023)), they had not been tested in this context until very recently (Winter-Hjelm et al, 2023). Despite qualitative indications from the literature, our Tesla valve-inspired designs performed relatively poorly in the rerouting of axonal outgrowth and the establishment of directional functional connectivity.…”

Section: Discussionmentioning

confidence: 96%

Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits

Mateus,

Melo,

Aroso

et al. 2024

Preprint

View full text Add to dashboard Cite

Understanding the intricate structure-function relationships of neuronal circuits is crucial for unraveling how the brain sustains efficient information transfer. In specific brain regions, like the hippocampus, neurons are organized in layers and form unidirectional connectivity, which is thought to help ensure controlled signal flow and information processing. In recent years, researchers have tried emulating these structural principles by providing cultured neurons with asymmetric environmental cues, namely microfluidics’ microchannels that promote directed axonal growth. Even though a few reports have claimed achieving unidirectional connectivity ofin vitroneuronal circuits, given the lack of functional characterization, whether this structural connectivity correlates with functional connectivity remains unknown.We have replicated and tested the performance of asymmetric microchannel designs previously reported in the literature to be successful in the promotion of directed axonal growth, as well as other custom variations. A new variation of “Arrowhead”, termed “Rams”, was the best-performing motif with a ∼76% probability per microchannel of allowing strictly unidirectional connections at 14 days in vitro. Importantly, we assessed the functional implications of these different asymmetric microchannel designs. For this purpose, we combined custom microfluidics with microelectrode array (MEA) technology to record the electrophysiological activity of two segregated populations of hippocampal neurons (“Source” and “Target”). This functional characterization revealed that up to ∼94% of the spiking activity recorded along microchannels with the “Rams” motif propagates towards the “Target” population. Moreover, our results indicate that these engineered circuits also tended to exhibit network-level synchronizations with defined directionality.Overall, this characterization of the structure-function relationships promoted by asymmetric microchannels has the potential to provide insights into how neuronal circuits use specific network architectures for effective computations. Moreover, the here-developed devices and approaches may be used in a wide range of applications, such as disease modeling or preclinical drug screening.

show abstract

Section: Discussionmentioning

confidence: 96%

Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits

Mateus,

Melo,

Aroso

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The distinctive architecture of Tesla valves is defined by their asymmetrical design and an arc-shaped channel. Tesla valve structures have found applications in various fields, leading to advancements in technologies like medical instruments, lab-on-a-chip systems, and chemosensors [85,86].…”

Section: System Componentsmentioning

confidence: 99%

Microfluidic Devices for Precision Nanoparticle Production

Bezelya,

Küçüktürkmen,

Bozkır

2023

Micro

View full text Add to dashboard Cite

In recent years, the field of drug delivery has seen a significant shift towards the exploration and utilization of nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs’ characteristics, microfluidics has emerged as a potent platform for the efficient and controlled synthesis of NPs. Microfluidic devices designed for precise fluid manipulation at the micro-scale offer a unique platform for tailoring NP properties, enabling enhanced control over NP properties such as size, morphology, and size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used to produce liposomes, solid lipid nanoparticles, polymer-based NPs, and lipid-polymer hybrid NPs, as well as a variety of inorganic NPs such as silica, metal, metal oxide, quantum dots, and carbon-based NPs, offering precise control over composition and surface properties. Its unique precision in tailoring NP properties holds great promise for advancing NP-based drug delivery systems in both clinical and industrial settings. Although challenges with large-scale production still remain, microfluidics offers a transformative approach to NP synthesis. In this review, starting from the historical development of microfluidic systems, the materials used to create the systems, microfabrication methods, and system components will be discussed in order to provide the reader with an overview of microfluidic systems. In the following, studies on the fabrication of nanoparticles such as lipid NPs, polymeric NPs, and inorganic NPs in microfluidic devices are included.

show abstract

“…The operating principle of the TV is rooted in fluid dynamics and the concept of fluid resistance. It comprises a series of specially shaped chambers or channels through which the fluid flows, typically arranged in an alternating pattern, with each chamber possessing a specific shape and orientation [5]. As the fluid flows in the intended direction, it encounters obstacles created by the chambers, leading to a pressure drop and turbulence in the flow.…”

Section: Introductionmentioning

confidence: 99%

Design and optimization of multistaged Tesla valves using response surface methodology

Gao,

Zhang,

et al. 2024

Fourth International Conference on Mechanical Engineering, Intelligent Manufacturing, and Automation Technology (MEMAT 2023)

View full text Add to dashboard Cite

This study presents a geometrically parameterized model for the Tesla valve and investigates the factors influencing its flow resistance characteristics. The research demonstrates that increasing the number of internal channels intensifies fluid collisions at intersection points, resulting in heightened pressure losses at bends and intersections in horizontal pipelines. The effectiveness of the modified Tesla valve structure is analyzed using finite element methods. Experimental validation corroborates the research findings. This study not only unveils the intricate mechanisms governing the flow resistance properties of the Tesla valve but also lays a scientific foundation for enhancing its performance. The practical experiments conducted contribute to validating theoretical advancements, underscoring the practical applicability of the research results. Overall, this study deepens the understanding of the complexity of the Tesla valve, providing a scientific basis for its optimization in practical engineering applications.

show abstract

Tesla Valve Microfluidics: The Rise of Forgotten Technology

Cited by 13 publications

References 80 publications

Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits

Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits

Microfluidic Devices for Precision Nanoparticle Production

Design and optimization of multistaged Tesla valves using response surface methodology

Contact Info

Product

Resources

About