Test–retest reliability and stability of N400 effects in a word-pair semantic priming paradigm

Kiang, Michael; Patriciu, Iulia; Roy, Carolyn; Christensen, Bruce K.; Zipursky, Robert B.

doi:10.1016/j.clinph.2012.09.029

Cited by 26 publications

(35 citation statements)

References 46 publications

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“…Because the recordings of the speeded condition were already completed before the inception of this study and the construction of the delayed setting, all subjects performed the speeded task first, followed by the delayed task at a later time. Since memory effects influence the N400 potential [16], subjects performed the latter experiment a minimum of 2 months after the first to mitigate these effects [17].…”

Section: Methodsmentioning

confidence: 99%

Response-Related Potentials during Semantic Priming: The Effect of a Speeded Button Response Task on ERPs

et al. 2014

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This study examines the influence of a button response task on the event-related potential (ERP) in a semantic priming experiment. Of particular interest is the N400 component. In many semantic priming studies, subjects are asked to respond to a stimulus as fast and accurately as possible by pressing a button. Response time (RT) is recorded in parallel with an electroencephalogram (EEG) for ERP analysis. In this case, the response occurs in the time window used for ERP analysis and response-related components may overlap with stimulus-locked ones such as the N400. This has led to a recommendation against such a design, although the issue has not been explored in depth. Since studies keep being published that disregard this issue, a more detailed examination of influence of response-related potentials on the ERP is needed. Two experiments were performed in which subjects pressed one of two buttons with their dominant hand in response to word-pairs with varying association strength (AS), indicating a personal judgement of association between the two words. In the first experiment, subjects were instructed to respond as fast and accurately as possible. In the second experiment, subjects delayed their button response to enforce a one second interval between the onset of the target word and the button response. Results show that in the first experiment a P3 component and motor-related potentials (MRPs) overlap with the N400 component, which can cause a misinterpretation of the latter. In order to study the N400 component, the button response should be delayed to avoid contamination of the ERP with response-related components.

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Section: Methodsmentioning

confidence: 99%

Response-Related Potentials during Semantic Priming: The Effect of a Speeded Button Response Task on ERPs

et al. 2014

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“…The present study used both behavioral (RT) and electroencephalogram (ERP) measures (N400) of SP in a test–retest, longitudinal within‐subject design in order to investigate whether semantic deficits are stable cognitive features of patients with schizophrenia or whether normal behavior may be reestablished at some stage during the course of the disorder over the period of a year. Given that in healthy individuals, SP is a stable cognitive measure of semantic processing, we assumed that it would remain stable between the two sessions . In contrast, in patients with schizophrenia, the SP effect would be influenced by the clinical characteristics of the patients in the test and retest sessions.…”

mentioning

confidence: 99%

Behavioral and brain measures (N400) of semantic priming in patients with schizophrenia: Test–retest effect in a longitudinal study

Besche‐Richard

Iakimova²,

Hardy-Baylé³

et al. 2014

Psychiatry Clin Neurosci

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Aim:The purpose of this study was to investigate whether deficits in the behavioral and/or N400 semantic priming (SP) effect observed in patients with schizophrenia constitute a stable cognitive feature of the disorder or whether they may be influenced by the severity of each individual's symptomatology. Methods:A 1-year test-retest study was conducted on 15 patients with schizophrenia and 10 healthy participants who performed an SP task. Both behavioral measures and event-related potentials measures of SP were recorded twice (test and retest sessions).Results: At test, patients exhibited a deficit in SP as was revealed by both the behavioral and the event-related potentials measures of the amplitude of the N400 component. At retest, behavioral SP remained impaired, whereas N400 SP was significantly improved. Conclusion:These results provide evidence that SP impairments in schizophrenia as measured by N400 should not be considered as stable cognitive markers of the disorder. The behavioral and the N400 measures of SP indicated different levels of sensitivity to subtle cognitive and brain processes, which are subject to change over the clinical course of schizophrenic disorder.

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“…The report in the present issue authored by Kiang and colleagues, “Test–retest reliability and stability of N400 effects in a word-pair semantic priming paradigm”, makes a significant contribution to the N400 and event-related potential (ERP) literatures (Kiang et al, 2013). In two sessions approximately 1 week apart, 16 normal participants performed a lexical decision task to visually-presented word pairs.…”

mentioning

confidence: 99%

“…The study results demonstrate high, but imperfect, test–retest reliability on N400 amplitude over a 1 week interval. Between ~62% and ~90% of the variance in the main N400 amplitude measures at the vertex (channel Cz) at time 2 could be accounted for by the N400 amplitude at time 1 (see Table 2, and Supplementary Table S1 in Kiang et al, 2013). In addition, significant effects of time were found on both N400 amplitude and latency.…”

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confidence: 99%

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Test–retest reliability and stability of N400 effects: Implications for the study of neuropsychiatric and cognitive disorders

Olichney

2013

Clinical Neurophysiology

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Test–retest reliability and stability of N400 effects in a word-pair semantic priming paradigm

Cited by 26 publications

References 46 publications

Response-Related Potentials during Semantic Priming: The Effect of a Speeded Button Response Task on ERPs

Response-Related Potentials during Semantic Priming: The Effect of a Speeded Button Response Task on ERPs

Behavioral and brain measures (N400) of semantic priming in patients with schizophrenia: Test–retest effect in a longitudinal study

Test–retest reliability and stability of N400 effects: Implications for the study of neuropsychiatric and cognitive disorders

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