“…As described in detail previously [12, 13], each 3D facial image was displayed on a 17-in LCD monitor (1701FP, Dell, Inc., Round Rock, TX, USA), scaled down to 75% of its actual size. The positions of 10 single and 8 paired landmarks (glabella [Gla], nasion [N], exocanthion [Ex], endocanthion [En], palpebrale superius [Ps], palpebrale inferius [Pi], porion [Po], orbitale [Or], pronasale [Prn], alar curvature point [Ac], subnasale [Sn], labiale superius [Ls], stomion [Sto], cheilion [Ch], labiale inferius [Li], submentale [Sm], pogonion [Pog], gnathion [Gn]) [14] (S1 Fig and S1 Table) were identified by visual inspection of the image using a computer mouse cursor, and digitized using commercial software (Face Rugle, Medic Engineering Co., Kyoto, Japan).…”