The present work aims to address the main prevention and care strategies for people with HIV/AIDS in Primary Health Care, through an integrative review of the literature. This is an integrative review of the literature, carried out in the Virtual Health Library (VHL). The databases selected were: Medical Literature Analysis and Retrieval System Online (MEDLINE), Latin American and Caribbean Literature in Health Sciences (LILACS), Spanish Bibliographic Index in Health Sciences (IBECS) and Nursing Database - BDENF. Using this search parameter, 937 articles were obtained and, after applying the inclusion and exclusion criteria, only 24 studies were selected to compose the final sample. The results show that prevention and care for people with HIV/AIDS are crucial aspects in the context of PHC, as its approach at this level of care seeks to promote health, prevent diseases and offer comprehensive assistance to the community, playing a role vital role in the comprehensive response to this health condition. The patient-user-centered approach, combined with education and health promotion, regular testing, encouraging the use of condoms, sexual and reproductive health care, counseling and psychological support, antiretroviral treatment, access and availability of PrEP and PeP, Combating stigma and discrimination, integrating RAS, epidemiological monitoring and training professionals is essential to guarantee prevention practices, the quality and effectiveness of the care provided.