Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report

Elzamly, Shaimaa; Padilla, Osvaldo

doi:10.1007/s12029-018-0172-6

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…Here, the tumour deposits outgrow their blood supply resulting in central necrosis leading to submucosal (occasionally even mucosal) erosions and ulcerations which can be visualised as submucosal or polypoid masses on endoscopy. 7 These masses can form a lead point for intussusception.…”

Section: Figure 1: (A) Ct Brain Showing a Heterogenous Rim Enhancing ...mentioning

confidence: 99%

“…Of the four reported cases, histology from three was reported as metastatic non-seminomatous GCT -two pure choriocarcinomas 7,8 and one a mixed germ cell tumour (embryonal carcinoma with yolk sac tumour). 9 In one case, the tumour was only reported as a metastatic germ cell tumour, and no distinction between the subtypes was included.…”

Section: Figure 1: (A) Ct Brain Showing a Heterogenous Rim Enhancing ...mentioning

confidence: 99%

“…With contemporary multimodal techniques involving chemotherapy, radiation and promising surgical procedures, 80% of patients will survive their disease. 7 Based on the International Germ Cell Cancer Collaborative Group (IGCCCG), our patient falls into the poor prognostic category with a 5-year survival of 67%. As was the case with our patient, two of the other four patients died in the perioperative period or after the initiation of intense chemotherapy.…”

Section: Figure 1: (A) Ct Brain Showing a Heterogenous Rim Enhancing ...mentioning

confidence: 99%

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Small bowel intussusception caused by a metastatic testicular germ cell tumour

John

Marais

Swanepoel³

et al. 2022

S. Afr. j. surg.

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Intussusception from a testicular germ cell tumour is extremely rare. Metastatic gastrointestinal implants outgrow their blood supply leading to central necrosis. This results in erosions and ulcerations, which can be visualised as submucosal polypoid masses. These masses can then serve as a lead point for intussusception. We report a case of a 25-year-old patient with small bowel obstruction due to an intussuscepted choriocarcinoma in the absence of any other apparent retroperitoneal disease. Urologists must exclude gastrointestinal tract (GIT) involvement in testicular cancers, and similarly, surgeons need to exclude testicular tumours in young men with unexplained GIT haemorrhage, bowel obstruction or intussusception.

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Section: Figure 1: (A) Ct Brain Showing a Heterogenous Rim Enhancing ...mentioning

confidence: 99%

Section: Figure 1: (A) Ct Brain Showing a Heterogenous Rim Enhancing ...mentioning

confidence: 99%

Section: Figure 1: (A) Ct Brain Showing a Heterogenous Rim Enhancing ...mentioning

confidence: 99%

See 1 more Smart Citation

Small bowel intussusception caused by a metastatic testicular germ cell tumour

John

Marais

Swanepoel³

et al. 2022

S. Afr. j. surg.

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“…Although the prognosis of choriocarcinoma is relatively good, its effects, including damage to multiple organs or injuries and pain accompanying chemotherapy, are harmful and approximately 40% of pregnancies with choriocarcinoma result in neonatal mortality [5]. Choriocarcinoma, a highly malignant epithelial cell tumor [6], is mainly characterized by immortalized trophoblast cells with uncontrolled proliferation, migration and invasion and distant metastasis to the blood vessels, lung, liver or brain [7][8][9][10]. Currently, the molecules involved in the tumorigenesis and metastasis of trophoblast cells are unclear, which is a major challenge to diagnosis and treatment.…”

Section: Ivyspringmentioning

confidence: 99%

Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells

Zhang¹,

Chen²,

Wang³

et al. 2021

Int. J. Med. Sci.

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Background: Placental-like chondroitin sulfate A (pl-CSA) is exclusively expressed in cancerous and placental tissues and is highly correlated with the degree of malignancy. However, the mechanism through which pl-CSA regulates tumorigenesis and metastasis in choriocarcinoma remains unclear. Methods: Stable transfectants of the JEG3 choriocarcinoma cell line, including a negative control (NC) line and a cell line with knockout of the biosynthetic enzyme CS synthase-2 (ChSy-2) (ChSy-2-/-), were obtained using CRISPR/Cas9 systems and identified by immunofluorescence, flow cytometry, western blots and enzyme-linked immunosorbent assays (ELISAs). The proliferation, migration, invasion and colony formation of the cells were determined by a cell counting kit, scratch-wound assays, transwell assays and soft agar colony formation assays in vitro, respectively. The tumorigenesis and metastasis of choriocarcinoma were also investigated through two xenograft models in vivo. Results: The ChSy-2 protein in the ChSy-2-/-group was below the detection threshold, which was accompanied a significant reduction in the pl-CSA level. Reducing pl-CSA through ChSy-2 knockout significantly inhibited cell proliferation, migration, invasion and colony formation in vitro and tumorigenesis and metastasis of choriocarcinoma, with deceases in tumor volume and metastatic foci and a high percent survival compared to the NC in vivo. Conclusion: pl-CSA, as a necessary component of JEG-3 cells, was efficiently reduced through ChSy-2 knockout, which significantly inhibited the tumorigenesis and metastasis of choriocarcinoma. ChSy-2/pl-CSA could be alternative targets for tumor therapy.

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Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report

Cited by 2 publications

References 23 publications

Small bowel intussusception caused by a metastatic testicular germ cell tumour

Small bowel intussusception caused by a metastatic testicular germ cell tumour

Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells

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