Testicular function following chemo–radiotherapy

Colpi, Giovanni M.; Contalbi, Gianfranco; Nerva, Franco; Sagone, P.; Piediferro, G.

doi:10.1016/j.ejogrb.2003.11.002

Cited by 131 publications

(97 citation statements)

References 35 publications

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“…5,6 Indeed, oncological treatments present severe gonadotoxic effects on both germ and Leydig cells. [7][8][9] Of note, in a significant percentage of patients (20%-50%) spermatogenesis is impaired even before cancer treatments, probably due to the malignancy itself. 10 The recovery of normal spermatogenesis after treatment may require several years, and mainly depends on three factors: initial sperm count, type and dose of specific oncological treatments and patient age.…”

Section: Introductionmentioning

confidence: 99%

Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders

Bisceglie¹,

Bertagna²,

Composto³

et al. 2013

Asian J Androl

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Pretherapy sperm cryopreservation in young men is currently included in good clinical practice guidelines for cancer patients. The aim of this paper is to outline the effects of different oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders, based on an 8-year experience of the Cryopreservation Centre of a large public hospital. Two hundred and sixty-one patients with testicular neoplasia and 219 patients with lymphoproliferative disorders who underwent chemotherapy and/or radiotherapy and pretherapy semen cryopreservation were evaluated. Sperm and hormonal parameters (follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, inhibin B levels) were assessed prior to and 6, 12, 18, 24 and 36 months after the end of cancer treatment. At the time of sperm collection, baseline FSH level and sperm concentration were impaired to a greater extent in patients with malignant testicular neoplasias than in patients with lymphoproliferative disorders. Toxic effects on spermatogenesis were still evident at 6 and 12 months after the end of cancer therapies, while an improvement of seminal parameters was observed after 18 months. In conclusion, an overall increase in sperm concentration was recorded about 18 months after the end of cancer treatments in the majority of patients, even if it was not possible to predict the evolution of each single case 'a priori '. For this reason, pretherapy semen cryopreservation should be considered in all young cancer patients.

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Section: Introductionmentioning

confidence: 99%

Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders

Bisceglie¹,

Bertagna²,

Composto³

et al. 2013

Asian J Androl

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“…It has been reported that increase in the cumulative alkylating agent dosage is associated with the inability to conceive. 6 Significant sperm DNA damage and low DNA compaction remained as long as 24 months posttreatment. 7 In this era of Assisted reproduction, appropriate counseling about fertility preservation techniques should be readily offered to all young cancer patients so as to provide them an opportunity to parent their own biological offspring.…”

Section: Discussionmentioning

confidence: 99%

“…So the frozen semen sample was thawed. Post-thaw semen analysis revealed a count of 3 x l0 6 ml with 2% motility.…”

Section: Methodsmentioning

confidence: 99%

A successful pregnancy outcome in a testicular cancer survivor: case report

Devi

Jagadeesan

Raghavan

2017

Int J Reprod Contracept Obstet Gynecol

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Testicular cancer is the most common cancer in young men. We report a successful pregnancy that was achieved by intracytoplasmic sperm injection (ICSI) using cryopreserved semen from a man with testicular cancer. He was treated for left testicular mixed germ cell tumor with left radical orchiectomy followed by chemotherapy. Three years post chemotherapy, the couple had two successive failures of intrauterine insemination (IUI) with cryopreserved semen. The couple then underwent Assisted reproduction with ICSI. Ten oocytes were retrieved following stimulation of which six oocytes fertilized and progressed. She had transfer of two healthy embryos and the remaining four embryos cryopreserved. Singleton pregnancy was achieved and she delivered a healthy girl baby at 38 weeks of gestation. Assisted reproduction with ICSI is a boon to the male patients with cancer and offers them a chance of fathering their own biological offspring.

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“…Some investigators (Giri et al, 1998;Colpi et al, 2004;Howell, Shalet, 2001) have reported that CDDP administration caused temporary or permanent azoospermia or oligospermia. In the present study, administration of CDDP reduced testicular and epididymal weights, sperm concentration when compared with the control group, indicating that CDDP caused testicular damage.…”

Section: Discussionmentioning

confidence: 99%