Testicular seminomatous mixed germ cell tumor with choriocarcinoma and teratoma with secondary somatic malignancy: a case report

Abstract

IntroductionTesticular tumors are a heterogeneous group of neoplasms exhibiting diverse histopathology and can be classified as seminomatous and non-seminomatous germ cell tumor types. Mixed germ cell tumors contain more than one germ cell component and various combinations have been reported. Here, we present a rare case of a mixed germ cell tumor composed of seminoma, choriocarcinoma and teratoma with a secondary somatic malignancy.Case presentationA 31-year-old Caucasian man presented with splenic rupture to our hospital. A right-sided testicular swelling had been present for 6 months and his alpha-fetoprotein, beta-human chorionic gonadotropin, and lactose dehydrogenase were increased. An ultrasound of his scrotum revealed an enlarged right testis with heterogeneous echogenicity. Multiple hypervascular lesions were noted in his liver and spleen. He underwent transcatheter embolization therapy of his splenic artery followed by splenectomy and right-sided orchiectomy. A computed tomography scan also showed metastasis to both lungs. During his last follow up after four cycles of cisplatin-based chemotherapy, the level of tumor markers had decreased, decreases in the size of his liver and pulmonary lesions were noted but new sclerotic lesions were evident in his thoracolumbar region raising concern for bony metastasis.ConclusionsPrognosis of testicular tumor depends mainly on the clinical stage, but emergence of a sarcomatous component presents a challenge in the treatment of germ cell tumors and the histological subtype of this component can be used as a guide to specific chemotherapy in these patients.

Malignant epidural spinal cord compression secondary to testicular cancer (mixed choriocarcinoma and seminoma) in the immediate post radical orchidectomy period

“…Up to 50% of these tumors are classified as mixed germ cell tumors, and several studies have assessed the frequency of the combination of histological components seen in these neoplasms. Choriocarcinoma and seminoma combination is reported to be extremely rare . Ashraf mosharafa et al also reported choriocarcinoma and seminoma to be the less common association.…”

“…The highest incidence of these neoplasms worldwide has been reported in white males . Tumors of the testis constitute a variety of neoplasms with wide‐ranging biological behaviors, histopathological, and clinical findings . Mixed germ cell tumors include combinations of seminomatous and nonseminomatous histological types, with the most common types being mixed embryonal carcinoma and teratoma, mixed teratoma and seminoma, as well as choriocarcinoma and teratoma .…”

“…Mixed germ cell tumors include combinations of seminomatous and nonseminomatous histological types, with the most common types being mixed embryonal carcinoma and teratoma, mixed teratoma and seminoma, as well as choriocarcinoma and teratoma . The combination of seminoma and choriocarcinoma is noted to be an exceptionally rare occurrence …”

Capecitabine-Induced Coronary Vasospasm

“…Our patient did not have CAD. Of note, 5-FU-mediated cardiotoxicity can occur in patients with no pre-existing CAD [5, 6, 7, 12]. …”

A rare case of pure primary hemangioma of the scapula: A case report

“…These rare, slow growing neoplasms may occur at any age, and account for ~1% of bone tumors (3)(4)(5). Hemangiomas may occur in any bone of the body, most commonly in the spine, craniofacial bone, skull, ribs and long bones (6)(7)(8)(9)(10)(11)(12)(13)(14)(15); however, occurrence in the scapula is extremely rare. Hemangiomas of the long bone or flat bone commonly have a 'foam' or 'honeycomb' appearance (16)(17)(18).…”