Testicular sperm extraction in men with sertoli cell-only testicular histology -
            1680 cases

Taitson, Paulo Franco; Filho, Antônio Mourthé; Radaelli, Moacir Rafael Martins

doi:10.5935/1518-0557.20190023

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Although finding sperm in patients categorized as SIGG 4 is not expected, a fertilization rate of 38.3 ± 30.6 % was achieved in those couples where menʼs biopsies were diagnosed as SIGG 4. This is consistent with a recently published study which showed that 14 % of patients with Sertoli-Cell-Only Syndrome [53]. However, this was not the case in the present study.…”

Section: Discussionsupporting

confidence: 93%

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Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Rehnitz

Rösner

Harsch

et al. 2020

Geburtshilfe Frauenheilkd

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Introduction Azoospermia affects about 1% of men, of whom up to 15% inquire about infertility treatment. Information about predictive factors for these couples is very limited. Patients, Materials and Methods We performed a retrospective analysis of the clinical records of 118 cycles of intracytoplasmic sperm injection treatment after testicular sperm extraction for male azoospermia carried out between January 2008 and October 2015. Of those, 66 were first, 35 second, and 17 third cycles. Statistical significance was set at p < 0.05. Predictive factors for successful pregnancy were evaluated and included male/female age, male/female body mass index, male/female nicotine use, and histological results of testes biopsies. Results Embryo quality and the number of embryos transferred were positively associated with pregnancy success (p = 0.003). Males whose partners conceived had a significantly lower body mass index than those whose partners did not conceive (p = 0.023). Neither female weight nor age nor smoking status of the male or female were significant factors. In cases with tubular atrophy ≥ SIGG grade 4 the chance of pregnancy was poor, irrespective of the existence of mature sperm and the number of cycles performed. Conclusion Overweight male patients should be advised about weight reduction prior to treatment, and counseling about success rates should include histological and sperm-positive biopsy results.

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Section: Discussionsupporting

confidence: 93%

“…In contrast, in 26.6% of patients categorized as SIGG 2, sperm could not be found. It has been suggested that once spermatozoa are found, fertilization and pregnancy rates do not differ significantly with regard to SIGG grade 53 . However, this was not the case in the present study.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Rehnitz

Rösner

Harsch

et al. 2020

Geburtshilfe Frauenheilkd

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“…SCs play a vital role in maintaining the homeostasis of spermatogenesis. Abnormal SC number and impaired SC physiological function directly affect the quality of sperm and even lead to germ cell apoptosis [ 88 , 89 , 90 ].…”

Section: Discussionmentioning

confidence: 99%

Probing the Potential Mechanism of Quercetin and Kaempferol against Heat Stress-Induced Sertoli Cell Injury: Through Integrating Network Pharmacology and Experimental Validation

Liu¹,

Liu²,

Hu³

et al. 2022

IJMS

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Quercetin and kaempferol are flavonoids widely present in fruits, vegetables, and medicinal plants. They have attracted much attention due to their antioxidant, anti-inflammatory, anticancer, antibacterial, and neuroprotective properties. As the guarantee cells in direct contact with germ cells, Sertoli cells exert the role of support, nutrition, and protection in spermatogenesis. In the current study, network pharmacology was used to explore the targets and signaling pathways of quercetin and kaempferol in treating spermatogenic disorders. In vitro experiments were integrated to verify the results of quercetin and kaempferol against heat stress-induced Sertoli cell injury. The online platform was used to analyze the GO biological pathway and KEGG pathway. The results of the network pharmacology showed that quercetin and kaempferol intervention in spermatogenesis disorders were mostly targeting the oxidative response to oxidative stress, the ROS metabolic process and the NFκB pathway. The results of the cell experiment showed that Quercetin and kaempferol can prevent the decline of cell viability induced by heat stress, reduce the expression levels of HSP70 and ROS in Sertoli cells, reduce p-NF-κB-p65 and p-IκB levels, up-regulate the expression of occludin, vimentin and F-actin in Sertoli cells, and protect cell structure. Our research is the first to demonstrate that quercetin and kaempferol may exert effects in resisting the injury of cell viability and structure under heat stress.

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“…[105][106][107] Deletions in the AZF region have been associated with altered sperm parameters and testicular histological characteristics such as Sertoli cellonly syndrome and hypo spermatogenesis. [108][109][110][111][112] The most common defects in spermatogenesis are microdeletions in the AZF region. These can be detected using molecular methods and are found in 5% to 10% of infertile men.…”

Section: Laboratory Characterisation Of Seminal Abnormalitiesmentioning

confidence: 99%

Male Infertility: A Retrospective Review of Laboratory Charts at a Tertiary Teaching Hospital in Nairobi City County

2024

EASci

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Background: Globally, approximately 50 million couples experience one form of infertility, and 10 million cases of subfertility have been reported in sub-Saharan Africa. Infertility is characterized by a lack of clinical conception among couples who live together for more than one year with regular coitus, without the use of contraception. Factors related to fertility vary by sex and geographical region. These factors include age, lifestyle, infectious diseases, and genetic disorders. In African culture, children are considered a simple inheritance and a measure of masculinity, so efforts are needed to address the growing problem of male infertility in this context. Objective: To determine the prevalence of male infertility among adult men seeking semen analysis services in a tertiary teaching hospital in Nairobi, Kenya. Methods: This was a cross-sectional study that involved a retrospective review of archived electronic data in the hospital information system. These data were from male patients who visited the laboratory with a request for semen analysis between January 2016 and December 2020. A checklist was used to extract data related to sociodemographic factors and laboratory results (age, seminal volume, and diagnosis). Results: The average age of the male clients seen during the review period was 36±8 years, with the majority aged 31-40 years n= 996 (46.7%). The youngest was 21 years old, and the oldest was 70 years old. The total prevalence of seminal abnormalities was 1628 (77%) of the 2131 electronic data that was reviewed. Only 502 (23%) of the patients had a normal seminal diagnosis. Most clients exhibited at least one form of seminal abnormalities, such as asthenospermia 913 (43%), oligospermia 441 (21%), and azoospermia 272 (13%). There was a statistically significant association between age and seminal abnormality (X 2 = 31.393, P=.013). A significant association was also found between seminal volume and abnormalities (X 2 = 94.538, P=.000). Conclusion: Our findings showed that there were some seminal abnormalities among Kenyan men in Nairobi County. More effort is required to identify the cause of this increase in seminal abnormalities. Initiation of health interventions to reduce this burden of infertility may be necessary. Peer Reviewed Acknowledgments:The authors thank Aga Khan University School of Nursing and Midwifery for giving us time to collect the data for this study. The authors also thank our departmental colleagues for their encouragement and help in conceptualising this study.

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Testicular sperm extraction in men with sertoli cell-only testicular histology - 1680 cases

Cited by 8 publications

References 21 publications

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients

Probing the Potential Mechanism of Quercetin and Kaempferol against Heat Stress-Induced Sertoli Cell Injury: Through Integrating Network Pharmacology and Experimental Validation

Male Infertility: A Retrospective Review of Laboratory Charts at a Tertiary Teaching Hospital in Nairobi City County

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