Testing Endothelial Function and its Clinical Relevance

Poredoš, Pavel; Ježovnik, Mateja K

doi:10.5551/jat.14340

Cited by 107 publications

(115 citation statements)

References 53 publications

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“…1 In this issue of the Journal, Sugihara et al reported for the first time that extremely low levels of SUA caused by SLC22A12/URAT1 loss-of-function mutations cause endothelial dysfunction in vivo, 12 as exhibited by flow-mediated dilation (FMD). 13 They initially found a positive correlation between SUA and FMD only in the hypouricemia group (SUA <2.5 mg/dl). Sequence analysis of genomic DNA revealed the clear differences in SUA levels between those groups.…”

Section: Editorial Effect Of Ua On Vascular Functionmentioning

confidence: 99%

Extremely Low Levels of Serum Uric Acid Are Associated With Endothelial Dysfunction in Humans

Iso

Kurabayashi

2015

Circ J

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978ISO T et al. Circulation JournalOfficial Journal of the Japanese Circulation Society http://www. j-circ.or.jp ative role of UA in CV risk is primarily supported by in vitro study results demonstrating that exposure of cultured endothelial cells to UA induces NADPH oxidase activity and the production of reactive oxygen species. 4 Conversely, the association between hyperuricemia and CV disease is only marginal or may be cofounded by other risk factors, such as hypertension, gout, and male sex. Likewise, hyperuricemia could be a consequence of impaired kidney function, diuretic therapy or oxidative stress, and as such, the role of SUA in conditions associated with oxidative stress is not entirely clear. 2 Increasing experimental and clinical evidence shows that SUA has an antioxidant role in vivo that protects the CV system. Studies have shown a J-shaped relationship of SUA with CV events. 5,6 For instance, the rate of CV events tended to be higher in SUA quartile 1 than in SUA quartile 2 in the PIUMA study ric acid (UA) is the endproduct of purine metabolism in humans. Most serum UA (SUA) is freely filtered in the glomerulus, and approximately 90% of the filtered SUA is reabsorbed, implying that SUA is likely to have a physiological role, rather than simply being a waste of purine metabolism. 1 Furthermore, the SUA level in humans is almost 10-fold higher than those in the majority of other mammals, which supports the hypothesis that the SUA level increased during human evolution as an advantage to humans. 1 Article p 1125Many epidemiological studies have demonstrated that increased SUA is associated with cardiovascular (CV) events in high-risk groups, such as patients with hypertension, heart failure, diabetes, and metabolic syndrome.

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Section: Editorial Effect Of Ua On Vascular Functionmentioning

confidence: 99%

Extremely Low Levels of Serum Uric Acid Are Associated With Endothelial Dysfunction in Humans

Iso

Kurabayashi

2015

Circ J

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“…18 The determination of venous endothelial function is more complicated and invasive and is less reproducible than FMD. 19 Microinvasive techniques such as the dorsal hand vein dilation capability and radionuclide assessment of changes in the volume of legs provide limited information about venous endothelial function. [20][21][22][23] However, as ED is expected to be a systemic disorder affecting the whole circulatory system (arteries, veins, and microcirculation), determination of endothelial function of peripheral arteries may also provide insight into venous functional status.…”

Section: Determination Of Ed and Its Involvement In Vtementioning

confidence: 99%

Endothelial Dysfunction and Venous Thrombosis

Poredoš

Ježovnik

2017

Angiology

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“…13, 14 Thus, in this study, we evaluated endothelial function using FMD in patients with renal hypouricemia.…”

Section: Human Umbilical Endothelial Cells (Huvec) and Ua Transportermentioning

confidence: 99%

Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia

Sugihara

Hisatome

Kuwabara

et al. 2015

Circ J

105

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Testing Endothelial Function and its Clinical Relevance

Cited by 107 publications

References 53 publications

Extremely Low Levels of Serum Uric Acid Are Associated With Endothelial Dysfunction in Humans

Extremely Low Levels of Serum Uric Acid Are Associated With Endothelial Dysfunction in Humans

Endothelial Dysfunction and Venous Thrombosis

Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia

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