Viticulture began growing in Brazil in recent years, and this growth is due to the introduction of new techniques and improvements used in vine planting, especially the use of plastic covering in the vineyard. Thus, this study aimed to evaluate the economic viability of plastic covering installation, as well as the quality of grapes produced by two cultivars, in order to compare these results with those obtained by a conventional cultivation system. The experiment was performed at an experimental farm producing grapes in southern Brazil. The grape cultivars Niagara Branca and Niagara Rosada were studied and cultivated with and without plastic covering. Data related to the costs of vineyard planting, establishment, and seasonal management, in addition to the grape revenue, were assessed. Additionally, the grape yield and quality were evaluated. The analysis of return indicators showed that the net present value was higher for the plastic-covered system, which indicates greater profitability and consequent viability of the investment. Moreover, the grape quality varied according to the cultivar and production system. In this context, it is recommended to use the cultivar Niagara Rosada for production in a plastic covering system.