Testing Methods and Toxicity Assessment (Including Alternatives)

Bruin, Yuri Bruinen de; Eskes, Chantra; Langezaal, Ingrid; Coecke, Sandra; Kinsner‐Ovaskainen, Agnieszka; Hakkinen, Pertti J.

doi:10.1016/b978-0-12-373593-5.00060-4

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…A pesar de los cambios en la normatividad con respecto a la utilización de animales en investigación, el modelo animal es probable que siga vigente por la variedad de ventajas que ofrece, por ejemplo, la constitución genética definida, así como la posibilidad de controlar la exposición y su duración, otra ventaja es la posibilidad de revisar los órganos (después de la necropsia). Las pruebas que evalúan toxicidad pueden realizarse in vivo (utilizando el animal completo), in vitro (probando en células o tejidos aislados) o por computadora (Bruinen de Bunin et al, 2009).…”

Section: Evaluación De La Toxicidad De Nanopartículas En Modelos Celu...unclassified

Pruebas toxicológicas para la evaluación de nanomateriales: Artículo de revisión

Salinas-Pérez,

Garrido-Hernández,

Gómez-Alonso

et al. 2023

ICBI

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Actualmente la nanotecnología es parte de la cuarta revolución industrial, ha aportado los avances científico-tecnológicos más importantes que haya conocido la humanidad. Gracias a ella ha sido posible aumentar la velocidad de los procesadores de computadoras, desarrollar materiales inteligentes, excluir contaminantes del agua, tierra y aire, diagnosticar y excluir a células cancerosas y en la liberación controlada de fármacos. Sin embargo, existen riesgos para el ser humano, en primer lugar, los efectos biológicos y químicos provocados por la exposición a las nanopartículas y, la eliminación de estos materiales al medio ambiente, que pueden afectar a los organismos y ecosistemas. La nanotoxicología determina la relación entre estructura y función de las nanopartículas con su toxicidad. En los últimos años se ha buscado reglamentar la bioseguridad en el uso de nanopartículas. Este trabajo aborda una revisión bibliográfica extensa de las pruebas toxicológicas para evaluar los efectos en la salud, provocados por la exposición a las nanopartículas

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Section: Evaluación De La Toxicidad De Nanopartículas En Modelos Celu...unclassified

Pruebas toxicológicas para la evaluación de nanomateriales: Artículo de revisión

Salinas-Pérez,

Garrido-Hernández,

Gómez-Alonso

et al. 2023

ICBI

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Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques

Kamil

Fatima

Ullah

et al. 2021

Toxics

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Toxicity studies were conducted to provide safety data of potential drug candidates by determining lethal and toxic doses. This study was designed for pre-clinical evaluation of novel cyclohexenone derivative with respect to the acute and sub-acute toxicity along with the diabetogenic potential. Acute and sub-acute toxicity were assessed after intraperitoneal (i.p) injection of the investigational compound through selected doses for 21 days. This was followed by assessment of isolated body organs (liver, kidney, heart and pancreas) via biochemical indicators and histopathological techniques. No signs of toxicity were revealed in the study of acute toxicity. Similarly, a sub-acute toxicity study showed no significant difference in biochemical indicators on 11th and 21st days between treated and control groups. However, in blood urea nitrogen (BUN) and random blood glucose/sugar (RBS) values, significant differences were recorded. Histopathological evaluation of liver, kidney, pancreas and heart tissues revealed mild to severe changes in the form of steatosis, inflammation, fibrosis, necrosis and myofibrillary damages on 11th and 21st days of treatment. In conclusion, the median lethal dose of the tested compound was expected to be greater than 500 mg/kg. No significant change occurred in selected biomarkers, except BUN and RBS levels, but a histopathological study showed moderate toxic effect on liver, kidney, pancreas and heart tissues by the cyclohexenone derivative.

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Skin Toxicity of Topically Applied Nanoparticles

et al. 2019

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Nowadays, nanoproducts have found numerous applications, allowing them to enter the human body in different ways. Skin is a major body organ that acts as the first-line barrier between the internal organs and external environment. Although the inhalation and ingestion of nanoparticles is more dangerous compared with skin exposure, there are noteworthy information gaps in skin exposure to nanoparticles that need much attention. Despite the few reviews in the literature on the cytotoxic effects of nanoparticles, no research has reviewed the clinical side effects of nanoparticles following topical admonition, including skin inflammation, skin cancer and genetic toxicity.

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Testing Methods and Toxicity Assessment (Including Alternatives)

Cited by 4 publications

References 22 publications

Pruebas toxicológicas para la evaluación de nanomateriales: Artículo de revisión

Pruebas toxicológicas para la evaluación de nanomateriales: Artículo de revisión

Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques

Skin Toxicity of Topically Applied Nanoparticles

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