The Italian forest nursery sector at the crossroads: challenges and strategies The recognition of the key role of forests in contrasting the dramatic effects of climate change and biodiversity crisis is the pillar of many initiatives on a global, European, and national scale calling for afforestation campaigns. The Italian forest nursery sector is currently inadequate to meet the demand for tree seedlings for the national campaigns. Forest nursery production is characterized by regional or local companies that are remarkably different from each other in organization and efficiency. It is therefore urgent to develop a comprehensive restructuring of the entire sector to be able to respond to the specific needs of forestry projects in Italy and Europe. In this paper, we present a series of key principles and criteria aimed at guiding the renaissance of the sector. Strategic actions are proposed by integrating research, governance, public/private partnership, training, and communication. The strategic approach presented is based on a collaborative structure integrating various skills and responsibilities. The first step is an expert review of the Basic Materials (BM) included in the National Register thanks to the development of the genetic studies of forest stands and the inclusion of shrub and herbaceous species, essentials for ecosystem restoration projects counteracting the biodiversity crisis. A series of actions concerns the aspects of certification, voluntary or prescriptive, of the quality of BM, and the ultimate harmonization of national production to European standards. Particular importance needs to be devoted to the collection, evaluation, and conservation of seeds to develop innovative solutions both for the production of BM and for specific implementation phases of afforestation projects and ecosystem restoration. The governance phase might be implemented through the creation of interregional centers with the duty of collecting and conserving seeds, thus enhancing the existing experiences of outstanding regional and provincial tree nurseries with the support of the National Centers for the study and conservation of Forest Biodiversity. Furthermore, the promotion of partnerships between public and private companies and the creation of a shared and accessible national platform represent strategic actions of primary importance. A fundamental role is then assigned to the implementation of training programs and the construction of an open and incremental communication plan. Thanks to these actions it will be possible to place forest nurseries at the center of the relationships between tree planting and afforestation plans and programs, integrated forest design, implementation of new forests, and their adaptive management.