Testosterone Concentration in Young Patients With Diabetes

Chandel, Anil; Dhindsa, Sandeep; Topiwala, Shehzad; Chaudhuri, Ajay; Dandona, Paresh

doi:10.2337/dc08-0851

Cited by 124 publications

(97 citation statements)

References 23 publications

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“…A prevalence of hypogonadism between 33 and 58% has been shown recently in younger diabetic men (ages [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35], when age-related reference ranges for testosterone were used. 13 Although diabetes is the most reported condition related to a high incidence of hypogonadism, many chronic illnesses are reported to be accompanied by a substantial incidence of low testosterone levels. 3,[14][15][16][17][18] Guay et al 19 have reported a prevalence of hypogonadism of 36.0% in men with ED seen in an endocrinology specialty center for sexual function and dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

2009

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The prevalence of hypogonadism has been found to be increased in certain chronic illnesses, especially diabetes, hypertension and obesity. Recently, the prevalence of hypogonadism in primary care practices mirrored that in our population of men with erectile dysfunction (ED). In this study, the prevalence of hypogonadism in nearly 1000 men with ED was tabulated, using a retrospective chart review, and analyzed for association with the various contributing medical and psychological factors. The prevalence of hypogonadism was determined in men with a variety of chronic illnesses, and was further characterized by decade. We observed an association between hypertension (P ¼ 0.025), tobacco abuse (P ¼ 0.0059), sleep apnea (P ¼ 0.0001), work stress (P ¼ 0.041) and hypogonadism. These data were further analyzed for the odds ratio and confidence interval (Forest plot), which showed strong association for sleep apnea and work stress. We did not observe any significant association between diabetes, atherosclerosis, alcohol abuse, multiple medications, asthma, seizure disorder, anxiety/depression and hypogonadism (P values for Cochran-Mantel-Haenszel general association were 0. 48, 0.97, 0.25, 0.69, 0.22, 0.76 and 0.98, respectively). We suggest that a host of chronic illnesses have a high prevalence of secondary hypogonadism. Men who have chronic medical or psychological illnesses should have their testosterone level checked, especially when sexual dysfunction symptoms or signs are present.

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Section: Introductionmentioning

confidence: 99%

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

2009

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“…Interestingly, this is not the case in men with type 1 diabetes. 10 Not only does testosterone replacement improve libido and sexual performance, but up to 60 per cent of men who do not respond to sildenafil become responders when testosterone is supplemented. 11 It is important to remember to check prostate-specific antigen levels regularly in men on testosterone replacement.…”

Section: Erectile Dysfunctionmentioning

confidence: 99%

Type 2 diabetes in men: facing the challenges

Karet¹

2012

Trends Urol & Men's Health

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“…Interestingly, there is a significant difference in plasma testosterone levels between men with diabetes type 1 (who have normal levels) and type 2 (who have subnormal levels) (6). This difference was attributed to the differences in circulating levels of insulin (low in type 1 and high in type 2).…”

Section: Testosterone In Men Suffering From Diabetes Mellitusmentioning

confidence: 99%

The role of testosterone in type 2 diabetes and metabolic syndrome in men

Saad

2009

Arq Bras Endocrinol Metab

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Over the last three decades, it has become apparent that testosterone plays a significant role in glucose homeostasis and lipid metabolism. The metabolic syndrome is a clustering of risk factors predisposing to diabetes mellitus type 2, atherosclerosis and cardiovascular morbidity and mortality. The main components of the syndrome are visceral obesity, insulin resistance, glucose intolerance, raised blood pressure and dyslipidemia (elevated triglycerides, low levels of high-density lipoprotein cholesterol), and a pro-inflammatory and thrombogenic state. Crosssectional epidemiological studies have reported a direct correlation between plasma testosterone and insulin sensitivity, and low testosterone levels are associated with an increased risk of type 2 diabetes mellitus, dramatically illustrated by androgen deprivation in men with prostate carcinoma. Lower total testosterone and sex hormone-binding globulin (SHBG) predict a higher incidence of the metabolic syndrome. There is evidence that hypotestosteronemia should be an element in the definition of the metabolic syndrome since low levels of testosterone are associated with or predict the development of the metabolic syndrome and of diabetes mellitus. Administration of testosterone to hypogonadal men reverses part of the unfavorable risk profile for the development of diabetes and atherosclerosis. So far, studies on the effects of normalization of testosterone in hypogonadal men on glucose homeostasis are limited, but convincing, and if diabetes mellitus is viewed in the context of the metabolic syndrome, the present results of testosterone treatment are very encouraging. Arq Bras Endocrinol Metab. 2009;53(8):901-7 Keywords Testosterone; metabolic syndrome; cardiovascular risk factors; insulin sensitivity; diabetes mellitus resumo Ao longo das últimas três décadas, tornou-se evidente que a testosterona desempenha um papel significativo na homeostase da glicose no metabolismo lipídico. A síndrome metabólica é um agrupamento de fatores de risco que predispõem ao diabetes melito tipo 2, aterosclerose e morbidade e mortalidade cardiovasculares. Os principais componentes da síndrome são: obesidade visceral, resistência insulínica, intolerância à glicose, hipertensão arterial e dislipidemia (triglicerídeos elevados, baixos níveis de HDL-colesterol), além de um estado pró-inflamatório e trombogênico. Estudos epidemiológicos transversais relataram uma correlação direta entre testosterona plasmática e sensibilidade à insulina, e níveis baixos de testosterona se associam com risco aumentado de diabetes tipo 2, ilustrado dramaticamente pela privação androgênica em homens com carcinoma de próstata. Baixos níveis de testosterona total e globulina transportadora de hormônios sexuais (SHBG) predizem maior incidência de síndrome metabólica. Existem agora evidências de que a hipotestosteronemia deveria ser um elemento na definição da síndro-me metabólica, uma vez que baixos níveis de testosterona estão associados ou predizem o desenvolvimento de síndrome metabólica e de...

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Testosterone Concentration in Young Patients With Diabetes

Cited by 124 publications

References 23 publications

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

Type 2 diabetes in men: facing the challenges

The role of testosterone in type 2 diabetes and metabolic syndrome in men

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