Testosterone effects on vasotocinergic innervation of sexually dimorphic medial preoptic nucleus and lateral septum during aging in male quail

Panzica, Giancarlo; García-Ojeda, E.; Viglietti‐Panzica, C.; Thompson, Nichola; Ottinger, Mary Ann

doi:10.1016/0006-8993(95)01386-5

“…In agreement with previous observations on quail (Viglietti-Panzica, 1986;Panzica et al, 1992aPanzica et al, , 1996aViglietti-Panzica et al, 1992Aste et al, 1997), VT-ir fibers are observed in the lateral septum, the periventricular hypothalamus, and the tuberal region. In particular, at the level of the preoptic area, a dense cluster of VT-ir fibers outlines the whole POM throughout its entire rostral-tocaudal extent .…”

Section: Vt Immunoreactivity In Malessupporting

confidence: 91%

“…A similar sensitivity to steroids has also been demonstrated for the VT-ir fibers in the lateral septum and in the POM (Viglietti-Panzica et al, 1992Panzica et al, 1996a). All of these studies demonstrated a prominent effect of testosterone, but it is not known at present whether this steroid needs to be aromatized into an estrogen in order to exert its effects, as shown previously in mammals (De Vries and Duetz, 1984;De Vries et al, 1986, 1994bBrot et al, 1993).…”

Section: Functional Significance Of the Quail Bstmsupporting

confidence: 57%

“…In particular, several studies have been devoted to the vasotocin (VT)-ir fibers of the POM and of the lateral septum, because these peptidergic structures are sexually dimorphic and steroidsensitive (Viglietti- Panzica et al, 1992Panzica et al, , 1994Panzica et al, 1996a;Aste et al, 1997; for review see Panzica et al, 1997). However, these studies have paid little attention to the distribution of this neuropeptide in the aforementioned region of the quail brain, which is located between the septum and the caudal aspects of the POM.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Anatomical and neurochemical definition of the nucleus of the stria terminalis in japanese quail (Coturnix japonica)

Aste

¹

,

Balthazart

²

,

Absil

³

et al. 1998

Self Cite

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This study in birds provides anatomical, immunohistochemical, and hodological data on a prosencephalic region in which the nomenclature is still a matter of discussion. In quail, this region is located just dorsal to the anterior commissure and extends from the level of the medial part of the preoptic area at its most rostral end to the caudal aspects of the nucleus preopticus medialis. At this caudal level, it reaches its maximal elongation and extends from the ventral tip of the lateral ventricles to the dorsolateral aspects of the paraventricular nucleus. This area contains aromatase-immunoreactive cells and a sexually dimorphic population of small, vasotocinergic neurons. The Nissl staining of adjacent sections revealed the presence of a cluster of intensely stained cells outlining the same region delineated by the vasotocin-immunoreactive structures. Cytoarchitectonic, immunohistochemical, and in situ hybridization data support the notion that this area is similar and is probably homologous to the medial part of the nucleus of the stria terminalis of the mammalian brain. The present data provide a clear definition of this nucleus in quail: They show for the first time the presence of sexually dimorphic vasotocinergic neurons in this region of the quail brain and provide the first detailed description of this region in an avian species.

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“…Castration also completely eliminates neurons expressing VT mRNA in the sexually dimorphic parvocellular VT cell groups, located in the POM and in the anterior and posterior part of the BSTm. These effects are completely reversed by a 3-week treatment with exogenous T. These changes are observed only at the level of the sexually dimorphic neurons of the limbic and preoptic regions and not at the level of the magnocellular neurons located in the paraventricular and supraoptic nuclei or at the level of the hypothalamo-neurohypophysial tract (17,(39)(40)(41)(42).…”

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 96%

“…In these conditions, the amount of VT-ir fibers in the lateral septum, BSTm, and POM, as well as the number of cells in the BSTm, dramatically decreases both in oscines [canary (37); junco (38)] and in nonoscine birds [quail (17,39)]. …”

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 99%

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Panzica

¹

,

Balthazart

²

,

Pessatti³

et al. 2002

Environ Health Perspect

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Vasotocin (VT; the antidiuretic hormone of birds) is synthesized by diencephalic magnocellular neurons projecting to the neurohypophysis. A sexually dimorphic system of VT-immunoreactive (ir) parvocellular elements has been described within the male medial preoptic nucleus (POM) and the nucleus of the stria terminalis, pars medialis (BSTm). VT-ir fibers are present in many diencephalic and extradiencephalic locations, and quantitative morphometric analyses demonstrated their sexually dimorphic distribution in regions involved in the control of different aspects of reproduction. Moreover, systemic or intracerebroventricular injections of VT markedly inhibit the expression of some aspects of male sexual behavior. In adult animals, circulating levels of testosterone (T) have a profound influence on the VT immunoreactivity within BSTm, POM, and lateral septum. Castration markedly decreases the immunoreaction, whereas T-replacement therapy restores a situation similar to the intact birds. We observed no changes in gonadectomized females treated with T. These changes parallel similar changes in male copulatory behavior (not present in castrated male quail, fully expressed in castrated, T-treated males). The restoration by T of the VT immunoreactivity in castrated male quail could be fully mimicked by a treatment with estradiol (E(2)), suggesting that the aromatization of T into E(2) may play a key limiting role in both the activation of male sexual behavior and the induction of VT synthesis. This dimorphism has an organizational nature: administration of E(2) to quail embryos (a treatment that abolishes male sexual behavior) results in a dramatic decrease of the VT immunoreactivity in sexually dimorphic regions. Conversely, the inhibition of E(2) synthesis during embryonic life (a treatment that stimulates the expression of male copulatory behavior in treated females exposed in adulthood to T) results in a malelike distribution of VT immunoreactivity. The VT parvocellular system of the Japanese quail can therefore be considered an accurate marker of the sexual differentiation of brain circuits mediating copulatory behavior and could be a very sensitive indicator of the activity of estrogenlike substances on neural circuits.

show abstract

Anatomical and neurochemical definition of the nucleus of the stria terminalis in japanese quail (Coturnix japonica)

Aste

¹

,

Balthazart

²

,

Absil

³

et al. 1998

Self Cite

View full text Add to dashboard Cite

This study in birds provides anatomical, immunohistochemical, and hodological data on a prosencephalic region in which the nomenclature is still a matter of discussion. In quail, this region is located just dorsal to the anterior commissure and extends from the level of the medial part of the preoptic area at its most rostral end to the caudal aspects of the nucleus preopticus medialis. At this caudal level, it reaches its maximal elongation and extends from the ventral tip of the lateral ventricles to the dorsolateral aspects of the paraventricular nucleus. This area contains aromatase-immunoreactive cells and a sexually dimorphic population of small, vasotocinergic neurons. The Nissl staining of adjacent sections revealed the presence of a cluster of intensely stained cells outlining the same region delineated by the vasotocin-immunoreactive structures. Cytoarchitectonic, immunohistochemical, and in situ hybridization data support the notion that this area is similar and is probably homologous to the medial part of the nucleus of the stria terminalis of the mammalian brain. The present data provide a clear definition of this nucleus in quail: They show for the first time the presence of sexually dimorphic vasotocinergic neurons in this region of the quail brain and provide the first detailed description of this region in an avian species.

show abstract

Testosterone effects on vasotocinergic innervation of sexually dimorphic medial preoptic nucleus and lateral septum during aging in male quail

Cited by 55 publications

References 36 publications

Anatomical and neurochemical definition of the nucleus of the stria terminalis in japanese quail (Coturnix japonica)

Anatomical and neurochemical definition of the nucleus of the stria terminalis in japanese quail (Coturnix japonica)

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Anatomical and neurochemical definition of the nucleus of the stria terminalis in japanese quail (Coturnix japonica)

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