Testosterone influences libido and well being in women

Davis, Susan R.; Tran, Jane

doi:10.1016/s1043-2760(00)00333-7

Cited by 156 publications

(86 citation statements)

References 43 publications

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“…desire; low testosterone levels have been correlated with sexual infrequency and reduced libido (18). However, few studies have examined the effects of androgen deficiency on sexual function, especially in a young age group.…”

Section: Minto Sexual Function In Complete Ais Fertil Steril 2003mentioning

confidence: 99%

Sexual function in women with complete androgen insensitivity syndrome

Minto

Liao

Conway

et al. 2003

Fertility and Sterility

148

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Section: Minto Sexual Function In Complete Ais Fertil Steril 2003mentioning

confidence: 99%

Sexual function in women with complete androgen insensitivity syndrome

Minto

Liao

Conway

et al. 2003

Fertility and Sterility

148

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“…4,5) Anabolic steroids were developed to reduce the side effects of androgens and to treat osteoporosis. However, their actions were not sufficient to reduce virilizing effects, and they exhibited hepatotoxic activity.…”

mentioning

confidence: 99%

Mechanism of the Tissue-Specific Action of the Selective Androgen Receptor Modulator S-101479

Furuya

Yamamoto

Ohyabu

et al. 2013

Biological & Pharmaceutical Bulletin

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Selective androgen receptor modulators (SARMs) comprise a new class of molecules that induce anabolic effects with fewer side effects than those of other anabolic agents. We previously reported that the novel SARM S-101479 had a tissue-selective bone anabolic effect with diminished side effects in female animals. However, the mechanism of its tissue selectivity is not well known. In this report, we show that S-101479 increased alkaline phosphatase activity and androgen receptor (AR) transcriptional activity in osteoblastic cell lines in the same manner as the natural androgen ligand dihydrotestosterone (DHT); conversely, stimulation of AR dimerization was very low compared with that of DHT (34.4%). S-101479 increased bone mineral content in ovariectomized rats without promoting endometrial proliferation. Yeast two-hybrid interaction assays revealed that DHT promoted recruitment of numerous cofactors to AR such as TIF2, SRC1, β-catenin, NCoA3, gelsolin and PROX1 in a dose-dependent manner. SARMs induced recruitment of fewer cofactors than DHT; in particular, S-101479 failed to induce recruitment of canonical p160 coactivators such as SRC1, TIF2 and notably NCoA3 but only stimulated binding of AR to gelsolin and PROX1. The results suggest that a full capability of the AR to dimerize and to effectively and unselectively recruit all canonical cofactors is not a prerequisite for transcriptional activity in osteoblastic cells and resulting anabolic effects in bone tissues. Instead, few relevant cofactors might be sufficient to promote AR activity in these tissues.

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“…Hormones affect the brain by binding to specific receptors, and previous work suggests that differences in the organization of brain areas in males and females depend on hormones (14)(15)(16). Hormones may affect cognition, mood, well-being, sexuality, and social behavior (16)(17)(18)(19).…”

mentioning

confidence: 99%

A randomized trial of the effect of estrogen and testosterone on economic behavior

Zethraeus

Kocoska-Maras²,

Ellingsen³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

181

145

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Existing correlative evidence suggests that sex hormones may affect economic behavior such as risk taking and reciprocal fairness. To test this hypothesis we conducted a double-blind randomized study. Two-hundred healthy postmenopausal women aged 50 -65 years were randomly allocated to 4 weeks of treatment with estrogen, testosterone, or placebo. At the end of the treatment period, the subjects participated in a series of economic experiments that measure altruism, reciprocal fairness, trust, trustworthiness, and risk attitudes. There was no significant effect of estrogen or testosterone on any of the studied behaviors.sex hormones ͉ trust game ͉ ultimatum game ͉ risk aversion H umans display sizeable individual variation in economic behaviors. Heterogeneity is large both in the domain of personal decision making and in the domain of social interaction. Some individuals willingly take risks that others pay to avoid (1), and in situations where some individuals are altruistic and trusting, others are selfish and distrustful (2).Relatively little is known about the sources of such preference heterogeneity, but two recent findings suggest that biological factors are important. First, comparisons of the behavior of identical and fraternal twins indicate that genetics explains a sizeable part of the variation in preferences across a wide range of economic domains (3-5). Second, a controlled increase in the level of the mammalian hormone oxytocin causes more trusting behavior (6).Several studies also report that behavior is correlated with the level of sex hormones. Burnham (7) finds that subjects with a higher testosterone level are more likely to reject unfair offers in the ultimatum game, and Apicella et al. (8) find a correlation between testosterone levels and financial risk-taking behavior. Two studies report that risk-taking behavior varies over the menstrual cycle; women are more risk averse during the ovulatory phase-that is, when the estrogen level is high (9, 10). Because hormone levels in general are under strong genetic influences (11,12), these relationships between hormone levels and behavior suggest one possible channel for the intergenerational transmission of behavior.Because men and women have sharply different levels of sex hormones, it is natural to think that hormones are implied in the differences between male and female behavior. Experimental evidence shows that, on average, women tend to be more risk averse, less competitive, and more prosocial than men (13). Hormones affect the brain by binding to specific receptors, and previous work suggests that differences in the organization of brain areas in males and females depend on hormones (14-16). Hormones may affect cognition, mood, well-being, sexuality, and social behavior (16)(17)(18)(19).However, the existing evidence on the relationship between sex hormones and economic behavior is merely correlative. It does not admit causal inference. To investigate whether there is a causal link, we conducted a double-blind randomized trial, with subjects...

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Testosterone influences libido and well being in women

Cited by 156 publications

References 43 publications

Sexual function in women with complete androgen insensitivity syndrome

Sexual function in women with complete androgen insensitivity syndrome

Mechanism of the Tissue-Specific Action of the Selective Androgen Receptor Modulator S-101479

A randomized trial of the effect of estrogen and testosterone on economic behavior

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