Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1/AMPK signaling in 3T3-L1 adipocytes

Mitsuhashi, Kazuteru; Senmaru, Takafumi; Fukuda, Takuya; Yamazaki, Masahiro; Shinomiya, Katsuhiko; Ueno, Masaki; Kinoshita, Shigeru; Kitawaki, Jo; Katsuyama, Masato; Tsujikawa, Masato; Obayashi, Hiroshi; Nakamura, Naoto; Fukui, Michiaki

doi:10.1007/s12020-015-0666-y

Cited by 48 publications

(43 citation statements)

References 36 publications

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“…For example, DDT/DDE (191) and some PCBs (344) have been reported to act as AR antagonists. Testosterone has been shown to stimulate glucose uptake in adipocytes (271). Additionally, a positive correlation between insulin sensitivity and testosterone levels has been reported in males (321).…”

Section: Effects Of Pops On At Functionmentioning

confidence: 99%

Adipose Tissue as a Site of Toxin Accumulation

Jackson

Shoemaker

Larian

et al. 2017

Comprehensive Physiology

144

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We examine the role of adipose tissue, typically considered an energy storage site, as a potential site of toxicant accumulation. Although the production of most persistent organic pollutants (POPs) was banned years ago, these toxicants persist in the environment due to their resistance to biodegradation and widespread distribution in various environmental forms (e.g., vapor, sediment, water). As a result, human exposure to these toxicants is inevitable. Largely due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in greater body burdens of these environmental toxicants with obesity. POPs of major concern include polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDDs/PCDFs), and polybrominated biphenyls and diphenyl ethers (PBBs/PBDEs), among other organic compounds. In this review, we 1) highlight the physical characteristics of toxicants that enable them to partition into and remain stored in adipose tissue, 2) discuss the specific mechanisms of action by which these toxicants act to influence adipocyte function, and 3) review associations between POP exposures and the development of obesity and diabetes. An area of controversy relates to the relative potential beneficial versus hazardous health effects of toxicant sequestration in adipose tissue.

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Section: Effects Of Pops On At Functionmentioning

confidence: 99%

Adipose Tissue as a Site of Toxin Accumulation

Jackson

Shoemaker

Larian

et al. 2017

Comprehensive Physiology

144

View full text Add to dashboard Cite

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“…[97][98][99][100] In adipocytes, it was confirmed that this regulation occurs through liver kinase B1/AMPK signaling. [97][98][99][100] In adipocytes, it was confirmed that this regulation occurs through liver kinase B1/AMPK signaling.…”

Section: Insulin-dependent Glut 4 Transporter In Pca: a Link Between mentioning

confidence: 99%

The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?

González-Menéndez

Hevia

Mayo

et al. 2017

Intl Journal of Cancer

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One of the hallmarks of cancer cells is the increased ability to acquire nutrients, particularly glucose and glutamine. Proliferating cells need precursors for cell growth and NADPH reducing equivalents for survival. The principal responsible for glucose uptake is facilitative glucose transporters (GLUTs), which usually are overexpressed in cancer cells. Besides their role in glucose uptake, GLUT transporters are able to transport other compounds such as dehydroascorbic acid or uric acid. They play a major role in tumor progression and cellular processes such as regulated cell death. The prostate gland has the particular characteristic of being more glycolytic than other non-pathological tissues given an accumulation of citrate in the seminal fluid and the inhibition of m-aconitase that affects to tricarboxylic acid cycle. In prostate cancer (PCa), androgens increase glucose uptake, upregulate GLUT transporters such as GLUT1 and GLUT3 and stimulate AMP-activated protein kinase pathway, suggesting a possible connection between glycolytic and androgenic signaling. Interestingly, diabetes is not a risk factor for PCa, as it is in other cancers, while insulin stimulates progression and insulin-like growth factor 1 pathway plays an important role in PCa progression. It was recently found that PCa cells overexpress GLUT4 and, more importantly, that it seems to be related to the castration-resistant prostate cancer (CRPC) phenotype, although little is known about its participation in tumor progression. This review will focus on the role of GLUT transporters along with PCa progression, and the involvement of GLUT4 on CRPC phenotype transition would be considered.

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“…In the general population, a clear relationship between the serum testosterone concentration and insulin sensitivity has been reported . Low testosterone levels are associated with increased insulin resistance, and the onset of insulin resistance may be influenced by testosterone levels .…”

Section: Postinfertility Management: Diagnosis Of Ks Is a Proxy Of Gementioning

confidence: 99%

Klinefelter syndrome: From pediatrics to geriatrics

Shiraishi

Matsuyama

2018

Reprod Medicine & Biology

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Background Klinefelter syndrome (KS) is one of the major causes of nonobstructive azoospermia (NOA). Microdissection testicular sperm extraction (micro‐TESE) is often performed to retrieve sperm. Infertility specialists have to care for KS patients on a lifelong basis. Methods Based on a literature review and our own experience, male infertility treatment and KS pathophysiology were considered on a lifelong basis. Main findings Patients diagnosed early often have an increased number of aberrant X chromosomes. Cryptorchidism and hypospadias are often found, and surgical correction is required. Cryopreservation of testicular sperm during adolescence is an issue of debate because the sperm retrieval rate (SRR) in KS patients decreases with age. The SRR in adult KS patients is higher than that in other patients with NOA; however, low testosterone levels after micro‐TESE will lower the general health and quality of life. KS men face a number of comorbidities, such as malignancies, metabolic syndrome, diabetes, cardiovascular disease, bone disease, and immune diseases, which ultimately results in increased mortality rates. Conclusion A deeper understanding of the pathophysiology of KS and the histories of KS patients before they seek infertility treatment, during which discussions with multidisciplinary teams are sometimes needed, will help to properly treat these patients.

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Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1/AMPK signaling in 3T3-L1 adipocytes

Cited by 48 publications

References 36 publications

Adipose Tissue as a Site of Toxin Accumulation

Adipose Tissue as a Site of Toxin Accumulation

The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?

Klinefelter syndrome: From pediatrics to geriatrics

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