Tests for ovarian reserve: reliability and utility

Domingues, T.S.; Rocha, A.M.; Serafini, P.

doi:10.1097/gco.0b013e32833b4f5c

Cited by 64 publications

(33 citation statements)

References 59 publications

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“…Among patients undergoing IVF, some variables like age, antiMullerian hormone (AMH) and day 3 follicle-stimulating hormone (FSH) circulating levels, and antral follicle count (AFC) allow identifying patients with poor ovarian reserve who will likely obtain a few oocytes in response to controlled ovarian stimulation (COH) [1]. These patients may be defined as "expected poor responders", and represent a subgroup of IVF patients in which several different COH regimens have been used trying to optimize oocyte yield.…”

Section: Introductionmentioning

confidence: 99%

“Mild” vs. “long” protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial

Revelli

Chiadò

Dalmasso³

et al. 2014

J Assist Reprod Genet

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Background This large prospective, randomized study was designed to compare the "mild" protocol with clomiphene citrate, low-dose gonadotropins and a GnRH-antagonist (CC/Gn/GnRH-ant protocol) with the "long" protocol with a GnRH-agonist and high-dose Gn for the controlled ovarian hyperstimulation (COH) of patients with expected poor ovarian responsiveness undergoing IVF. Materials and Methods A total of 695 women with clinical, endocrine and ultrasound characteristics suggesting a low ovarian reserve and a poor responsiveness to COH were recruited and randomly assigned to receive the CC/Gn/ GnRH-ant "mild" protocol (mild group, n=355) or the "long" protocol with high-dose Gn (long group, n=340). Results The "mild" stimulation led to significantly shorter follicular phase, lower consumption of exogenous Gn and lower peak estradiol level than the "long" regimen. With the "long" protocol, significantly less cycles were cancelled due to the lack of ovarian response; further, it obtained significantly more oocytes, more mature oocytes, more embryos, and a thicker endometrium. As for the final IVF outcome, however, the two stimulation regimens obtained comparable implantation rate, clinical pregnancy rate, and ongoing pregnancy rate at 12 weeks. Conclusions In conclusion, the "mild" CC/Gn/GnRH-ant stimulation protocol is a valid alternative to the long protocol with high Gn dose as it obtains a comparable success rate and requires significantly less medications, with an obvious economical advantage.

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Section: Introductionmentioning

confidence: 99%

“Mild” vs. “long” protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial

Revelli

Chiadò

Dalmasso³

et al. 2014

J Assist Reprod Genet

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“…However, ovarian volume is known to decrease with ovarian aging . During menopause, loss in ovarian volume reaches to its peak level (19) . …”

Section: Parameter Valuementioning

confidence: 99%

Efficacy of internal iliac artery ligation on the management of postpartum hemorrhage and its impact on ovarian reserve

Şimşek¹,

Yılmaz²,

Çelik³

et al. 2012

J Turk Soc Obstet Gynecol

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SUMMARY Aim Thirteen of those underwent the ligation of bilateral internal iliac artery. The mean age of 32 (24 -44), mean gravida 3,2 (1 -5), mean parity 2 (0 -4), mean birth week 38 (35 -41) and mean birth weight were 3373 g (2500 -4200). The effectiveness of bilateral internal iliac artery ligation was 84,7%. FSH and estradiol concentrations and the mean volume of the ovarieswere similar between the study (n:10) and control (n:56) groups (P= 0.650, P= 0.245 and P=0.281, respectively).

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“…Additionally, we used AFC, not AMH, as an indicator of ovarian reserve. Several studies have correlated sonographic AFC with serum AMH and FSH levels for predicting the ovarian response to gonadotropin stimulation protocols [15,28].…”

Section: Discussionmentioning

confidence: 99%

FMR1 Repeats and Ovarian Reserve: CGG Repeat Number does not Influence Antral Follicle Count

Spitzer¹,

Johnstone²,

Huddleston³

et al. 2012

J Fertiliz In Vitro

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Tests for ovarian reserve: reliability and utility

Cited by 64 publications

References 59 publications

“Mild” vs. “long” protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial

“Mild” vs. “long” protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial

Efficacy of internal iliac artery ligation on the management of postpartum hemorrhage and its impact on ovarian reserve

FMR1 Repeats and Ovarian Reserve: CGG Repeat Number does not Influence Antral Follicle Count

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