Tests of a linear model of visual-vestibular interaction using the technique of parameter estimation

Das, Vallabh E.; DiScenna, Alfred O.; Feltz, Andrew; Yaniglos, S.; Leigh, R. John

doi:10.1007/s004220050425

Cited by 13 publications

(20 citation statements)

References 36 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been previously applied to the study of eye movements (Huebner et al 1990;Seidman et al 1995;Das et al 1998). Due to the complexity of the SVBN model, we did not attempt to write down the state equations describing the model; instead we took advantage of the seamless integration of SIMULINK with MATLAB (The Mathworks Inc.,) to execute the model at each iterative step of the parameter estimation procedure.…”

Section: Testing Of Models For Saccade-vergence Interactionsmentioning

confidence: 99%

Tests of Models for Saccade–Vergence Interaction using Novel Stimulus Conditions

et al. 2006

Self Cite

View full text Add to dashboard Cite

During natural activities, two types of eye movements - saccades and vergence - are used in concert to point the fovea of each eye at features of interest. Some electrophysiological studies support the concept of independent neurobiological substrates for saccades and vergence, namely saccadic and vergence burst neurons. Discerning the interaction of these two components is complicated by the near-synchronous occurrence of saccadic and vergence components. However, by positioning the far target below the near target, it is possible to induce responses in which the peak velocity of the vertical saccadic component precedes the peak velocity of the horizontal vergence component by approximately 75 ms. When saccade-vergence responses are temporally dissociated in this way, the vergence velocity waveform changes, becoming less skewed. We excluded the possibility that such change in skewing was due to visual feedback by showing that similar behavior occurred in darkness. We then tested a saccade-related vergence burst neuron (SVBN) model proposed by Zee et al. in J Neurophysiol 68:1624-1641 (1992), in which omnipause neurons remove inhibition from both saccadic and vergence burst neurons. The technique of parameter estimation was used to calculate optimal values for responses from human subjects in which saccadic and convergence components of response were either nearly synchronized or temporally dissociated. Although the SVBN model could account for convergence waveforms when saccadic and vergence components were nearly synchronized, it could not when the components were temporally dissociated. We modified the model so that the saccadic pulse changed the parameter values of the convergence burst units if both components were synchronized. The modified model accounted for velocity waveforms of both synchronous and dissociated convergence movements. We conclude that both the saccadic pulse and omnipause neuron inhibition influence the generation of vergence movements when they are made synchronously with saccades.

show abstract

Section: Testing Of Models For Saccade-vergence Interactionsmentioning

confidence: 99%

Tests of Models for Saccade–Vergence Interaction using Novel Stimulus Conditions

et al. 2006

Self Cite

View full text Add to dashboard Cite

show abstract

“…Early studies found visually sensitive neurons in the rNRTP and DLPN. Such signals could play a role in supporting the vestibular ocular reflex (VOR) because residual retinal slip during the VOR engages optokinetic or smooth pursuit mechanisms to produce further compensation for head movements over a broad frequency range (Das et al 1998;Raymond and Lisberger 1998). In this study, we attempt to characterize the role of the DLPN and rNRTP in relation to horizontal eye motion in space during behavior requiring interaction between visual and vestibular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Gaze-Related Response Properties of DLPN and NRTP Neurons in the Rhesus Macaque

Ono

Das

Mustari

2004

Journal of Neurophysiology

Self Cite

View full text Add to dashboard Cite

Ono, Seiji, Vallabh E. Das, and Michael J. Mustari. Gaze-related response properties of DLPN and NRTP neurons in the rhesus macaque. J Neurophysiol 91: 2484 -2500, 2004. First published January 28, 2004 10.1152/jn.01005.2003. The dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) are basilar pontine nuclei important for control of eye movements. The aim of this study was to compare the response properties of neurons in DLPN and rostral NRTP (rNRTP) during visual, oculomotor, and vestibular testing. We tested 51 DLPN neurons that were modulated during smooth pursuit (23/51) or during motion of a large-field visual stimulus (28/51). Following vestibular testing, we found that the majority of smooth pursuit-related neurons in DLPN were best classified as gaze (13/23) or eye velocity (7/23) related. Only a small percentage (3/51) of DLPN neurons responded during vestibular ocular reflex in the dark (VORd). We tested rNRTP neurons as described above and found the majority of neurons (35/43) were modulated during smooth pursuit or during motion of a large-field stimulus only (4/43). A significant proportion of our rNRTP gaze velocity neurons (10/18) were also modulated during VORd. We found that the majority of smooth pursuit related neurons in rNRTP were best classified as gaze velocity (18/35) or gaze acceleration (11/35) sensitive. The remaining neurons were classified as eye position or eye/head related. We used multiple linear-regression modeling to determine the relative contributions of eye, head and visual inputs to the responses of DLPN and rNRTP neurons. Our results support the suggestion that both DLPN and rNRTP play significant roles not only in control of smooth pursuit but also in control of gaze.

show abstract

“…The gain and phase of the VOR in the light (VORl) and dark (VORd) have been well characterized for a range of head-perturbation frequencies in humans and non-human primates (e.g., Barr et al 1976;Correia et al 1985;Das et al 1998;Minor et al 1999;Paige 1983). These studies have shown that the gain of the VOR is higher when viewing a stationary target in the light than when imagining a target in complete darkness, suggesting cooperation between the VOR and visually mediated eye movements.…”

Section: Introductionmentioning

confidence: 99%

Role of the Dorsolateral Pontine Nucleus in Short-Term Adaptation of the Horizontal Vestibuloocular Reflex

Ono¹,

Das

Mustari

2003

Journal of Neurophysiology

Self Cite

View full text Add to dashboard Cite

Ono, Seiji, V. E. Das, and M. J. Mustari. Role of the dorsolateral pontine nucleus in short-term adaptation of the horizontal vestibuloocular reflex. J Neurophysiol 89: 2879 -2885, 2003; 10.1152/jn.00602.2002. The dorsolateral pontine nucleus (DLPN) is a major component of the cortico-ponto-cerebellar pathway that carries signals essential for smooth pursuit. This pathway also carries visual signals that could play a role in visually guided motor learning in the vestibular ocular reflex (VOR). However, there have been no previous studies that tested this possibility directly. The aim of this study was to determine the potential role of the DLPN in short-term VOR gain adaptation produced by viewing a scene through lenses placed in front of both eyes. In control experiments, adaptation of VOR gain was achieved by sinusoidal rotation (0.2 Hz, 30°/s) for 2 h while the monkey viewed a stationary visual surround through either magnifying (ϫ2) or minifying (ϫ0.5) lenses. This led to increases (23-32%) or decreases (22-48%) of VOR gain as measured in complete darkness (VORd). We used injections of muscimol, a potent GABA A agonist (0.5 l; 2%), to reversibly inactivate the DLPN, unilaterally, in three monkeys. After DLPN inactivation, initial acceleration of ipsilateral smoothpursuit was reduced by 35-68%, and steady-state gain was reduced by 32-61%. Despite these significant deficits (P Ͻ 0.01) in ipsilesional smooth pursuit, the VOR during lens viewing was similar to that measured in preinjection control experiments. Similarly, after 2 h of adaptation, VORd gain was not significantly different (P Ͼ 0.61) from control adaptation values for either ipsi-or contralesional directions of head rotation. This was the case even though a stable ipsilesional smooth pursuit deficit persisted throughout the full adaptation period. Our results suggest that visual error signals for short-term adaptation of the VOR are derived from sources other than the DLPN perhaps including other basilar pontine nuclei and the accessory optic system.

show abstract

Tests of a linear model of visual-vestibular interaction using the technique of parameter estimation

Cited by 13 publications

References 36 publications

Tests of Models for Saccade–Vergence Interaction using Novel Stimulus Conditions

Tests of Models for Saccade–Vergence Interaction using Novel Stimulus Conditions

Gaze-Related Response Properties of DLPN and NRTP Neurons in the Rhesus Macaque

Role of the Dorsolateral Pontine Nucleus in Short-Term Adaptation of the Horizontal Vestibuloocular Reflex

Contact Info

Product

Resources

About