“TET-on” pluripotency

Glycome as Biomarkers

“…The core reprogramming factors Oct4 and Sox2 are O-GlcNAcylated in ESCs, but the O-GlcNAc modification is rapidly removed upon differentiation (Jang et al 2012). Recently, 10-11 translocation 1-3 proteins functioning as DNA hydroxylases were reported to interact with O-linked GlcNAc transferase to mediate histone modifications and regulate gene expression (Wang et al 2013).…”

Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer

“…However, TET family proteins have also been implicated in CRC development, as their dysregulation can alter the epigenetic landscape in colonocytes to promote malignant transformation [12]. TET enzymes were extensively linked to the regulation of pluripotency and self-renewal, two key features of cancer stem cells and hierarchical tumor heterogeneity [14,15]. DNA hypomethylation has also been associated with the increased mobility of transposable elements, which constitute a large proportion of the eukaryotic genome and Collectively, Ansari et al illuminate the importance of investigations evaluating dysbiosis at the molecular level, with specific regard to DNA methylation, as a causative driver of colorectal carcinogenesis.…”