Tetrahydro curcumin loaded PCL-PEG electrospun transdermal nanofiber patch: Preparation, characterization, and in vitro diffusion evaluations

Ravikumar, Rramaswamy; Ganesh, Mani; Senthil, V.; Nagarkar, Raj; Jakki, Satya Lavanya; Choi, Eun Young

doi:10.1016/j.jddst.2018.01.016

Cited by 60 publications

(32 citation statements)

References 32 publications

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“…Although curcumin has a favourable molecular weight (368 Da) for transdermal delivery, other parameters such as its low aqueous solubility and relatively high log P of 3.2 require additional enhancement techniques for skin penetration (10)(11)(12)(13). Numerous studies have aimed at improving curcumin bioavailability and stability by a variety of different approaches including formulation into nanoparticles (14), nanogels (15), microemulsions (16,17), nanofibre transdermal patches (18)(19)(20), micelles (21,22), polymeric conjugates (23,24) or lipid vesicles (25,26). Polymeric nanoparticles are widely used in drug delivery systems because of their biocompatibility and biodegradability (27).…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery

et al. 2019

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Curcumin-loaded chitosan nanoparticles were synthesised and evaluated in vitro for enhanced transdermal delivery. Zetasizer® characterisation of three different formulations of curcumin nanoparticles (Cu-NPs) showed the size ranged from 167.3 ± 3.8 nm to 251.5 ± 5.8 nm, the polydispersity index (PDI) values were between 0.26 and 0.46 and the zeta potential values were positive (+ 18.1 to + 20.2 mV). Scanning electron microscopy (SEM) images supported this size data and confirmed the spherical shape of the nanoparticles. All the formulations showed excellent entrapment efficiency above 80%. FTIR results demonstrate the interaction between chitosan and sodium tripolyphosphate (TPP) and confirm the presence of curcumin in the nanoparticle. Differential scanning calorimetry (DSC) studies of Cu-NPs indicate the presence of curcumin in a disordered crystalline or amorphous state, suggesting the interaction between the drug and the polymer. Drug release studies showed an improved drug release at pH 5.0 than in pH 7.4 and followed a zero order kinetics. The in vitro permeation studies through Strat-M® membrane demonstrated an enhanced permeation of Cu-NPs compared to aqueous curcumin solution (p 0.05) having a flux of 0.54 ± 0.03 μg cm −2 h −1 and 0.44 ± 0.03 μg cm −2 h −1 corresponding to formulations 5:1 and 3:1, respectively. The cytotoxicity assay on human keratinocyte (HaCat) cells showed enhanced percentage cell viability of Cu-NPs compared to curcumin solution. Cu-NPs developed in this study exhibit superior drug release and enhanced transdermal permeation of curcumin and superior percentage cell viability. Further ex vivo and in vivo evaluations will be conducted to support these findings.

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Section: Introductionmentioning

confidence: 99%

An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery

et al. 2019

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“…The same was observed by Rramaswamy et al using tetrahydro curcumin loaded onto PCL/PEG hybrid formulations processed in the form of electrospun hybridized transdermal patches. They also concluded that drug diffusion in such systems follows Higuchi's model diffusion mechanism [232].…”

Section: Transdermalmentioning

confidence: 99%

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

et al. 2020

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Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a target-directed action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.

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“…In vitro diffusion study is an important preliminary evaluation method in determining in vivo drug release [57]. Usually, this test is performed using a Franz Diffusion Cell, in which there is a donor compartment and a receptor compartment.…”

Section: In Vitro Diffusion Studymentioning

confidence: 99%

“…Usually, this test is performed using a Franz Diffusion Cell, in which there is a donor compartment and a receptor compartment. The two compartments use animal skins as membranes, such as rat skin [8] and pigskin [57].…”

Section: In Vitro Diffusion Studymentioning

confidence: 99%

A Review: Anti-Cancer Natural Product Drug Delivery System Dosage Form and Evaluation

2021

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A drug delivery system is a system in which a drug is released from a pharmaceutical dosage form to achieve the desired pharmacological effect. The system consists of conventional and new drug delivery systems. In the new drug delivery system, polymers are used as a matrix. The aim of this article is to find out and understand the formulation and evaluation of natural ingredients that have anticancer activity with different dosage forms and the basis for developing these dosages. Journal searches in this review came from primary data sources on the internet. Journal searches were carried out using a search engine such as Google Scholar, PubMed, and ScienceDirect. In recent years, natural products, such as extract, fraction, and isolate, are getting attention to help treat cancer. Because of their low solubility and bioavailability, the effectiveness tends to be lower than synthetic drugs. Therefore, a dosage form with a new drug delivery system was made to overcome the problem. The dosage forms commonly made are patch, suspension, powder, and emulsion with a new drug delivery system. To ensure the product that has been made met the requirements, they need to be evaluated with various methods like In vitro Study, morphology study, particle size study, and others. Cancer treatment using the natural product can be delivered through several dosage forms like patch, suspension, powder, and emulsion, with specific formulation and manufacturing methods based on several considerations such as natural ingredients properties, dosage form selection, excipient properties, and the purpose of the formulation. Dosage forms that has been made are then evaluated using several evaluation methods.

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Tetrahydro curcumin loaded PCL-PEG electrospun transdermal nanofiber patch: Preparation, characterization, and in vitro diffusion evaluations

Cited by 60 publications

References 32 publications

An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery

An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

A Review: Anti-Cancer Natural Product Drug Delivery System Dosage Form and Evaluation

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