Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Greeshma, N.; Prasanth, K. G.; Bhaskar, B.

doi:10.1016/j.cbi.2015.06.025

Cited by 43 publications

(36 citation statements)

References 43 publications

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“…The symptoms include mild tingling, spontaneous painful burning paresthesia and hyperalgesia. The mechanism through which VINCRI produces CIPN are still unclear, but it is known that VINCRI‐induced neuropathic pain is due to neuronal toxicity and/or neurological disorder …”

Section: Chemotherapy‐induced Peripheral Neuropathy – Mechanisms Of Fmentioning

confidence: 99%

“…Antioxidant agents have shown a protective effect against free radical damage, what can be the cause of many diseases. In order to find out a successful treatment for CIPN, animal studies (since pharmacological and mechanical tests until histopathological and immunohistochemical analyses) have been developed to try to determinate the action of antioxidant agents …”

Section: Introductionmentioning

confidence: 99%

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The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

Carvalho

Silva

Carvalho

2017

Clin Exp Pharma Physio

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SummaryAntineoplastic drugs such as cisplatin, oxaliplatin, paclitaxel and vincristin are widely used in the treatment of several solid and blood tumours. However, the severity of peripheral neuropathy caused by these agents can affect the patient's quality of life.The major symptoms of chemotherapy-induced peripheral neuropathy (CIPN) involve: sensory loss, paresthesia, dysesthaesia, numbness, tingling, temperature sensitivity, allodynia and hyperalgesia, in a "stocking and glove" distribution. Why many different chemotherapeutic agents result in similar neuropathy profiles is unclear. Many drug classes such as antidepressants, anticonvulsants, antispastic agents and others have been used in clinical practice, but there is no scientific evidence to prove their effectiveness. But drugs as the antioxidant have shown a protective effect against free radical damage. In order to find out a successful treatment for CIPN, animal studies (ie pharmacological and mechanical tests and histopathological immunohistochemical analyses) have been developed to try to determinate the action of the antioxidant agents. This review provides an overview of the major antioxidant agents recently investigated to treat CIPN and the animal models used for this purpose. K E Y W O R D Santineoplastic drugs, antioxidants, peripheral neuropathy

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Section: Chemotherapy‐induced Peripheral Neuropathy – Mechanisms Of Fmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

Carvalho

Silva

Carvalho

2017

Clin Exp Pharma Physio

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“…Dihydrocurcumin (DHC), demethoxycurcumin, bis-demethoxycurcumin and the reductive metabolites with glucuronic acid and sulfate were also disclosed, and CUR-glucuronoside, DHC-glucuronoside, THC-glucuronoside and THC were the major metabolites of CUR in mice (Hoehle, Pfeiffer, Sólyom, & Metzler, 2006;Pan, Huang, & Lin, 1999). For example, THC could relieve sciatic nerve injury in rats (Greeshma, Prasanth, & Balaji, 2015) and DHC could prevent the release of glycosaminoglycans induced by antigens in RBL-2H3 cells, which may inhibit allergic diseases (Matsuda, Tewtrakul, Morikawa, Nakamura, & Yoshikawa, 2004). For example, THC could relieve sciatic nerve injury in rats (Greeshma, Prasanth, & Balaji, 2015) and DHC could prevent the release of glycosaminoglycans induced by antigens in RBL-2H3 cells, which may inhibit allergic diseases (Matsuda, Tewtrakul, Morikawa, Nakamura, & Yoshikawa, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Although many metabolites were thought to be inactive, many studies have suggested that some of the metabolites of CUR also possess important biological activities. For example, THC could relieve sciatic nerve injury in rats (Greeshma, Prasanth, & Balaji, 2015) and DHC could prevent the release of glycosaminoglycans induced by antigens in RBL-2H3 cells, which may inhibit allergic diseases (Matsuda, Tewtrakul, Morikawa, Nakamura, & Yoshikawa, 2004).…”

mentioning

confidence: 99%

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

Wang

Zhang³

et al. 2018

Biomedical Chromatography

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Curcumin (CUR) is the major active component of turmeric and plays an important role in the prevention and treatment of many chronic diseases such as respiratory and neurodegenerative disease. In the present work, a rapid and simple LC-MS/MS method was developed to investigate the pharmacokinetics and tissue distribution of CUR and its metabolites in mice after intravenous administration of CUR (20 mg/kg). The results showed that the values of AUC were 107.0 ± 18.3, 6.0 ± 1.2 and 12.0 ± 4.0 (mg/L) min, and those for t were 32.4 ± 10.8, 6.4 ± 2.4 and 5.6 ± 1.8 min for CUR, dihydrocurcumin (DHC) and tetrahydrocurcumin (THC) in plasma, respectively. CUR and THC could be detected in liver while CUR and DHC were detected in kidney. Only CUR was detected in brain. These findings indicated that THC was the main metabolite of CUR in plasma. The exposure of CUR in plasma was 6-fold greater than that in liver, kidney and brain.

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“…www.anesth-pain-med.org a synthetic curcuminoid analog reduced both formalin-and thermally induced nociception and neuropathic pain [29,30].…”

mentioning

confidence: 99%

Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

Shin

Yoon

et al. 2018

Anesth Pain Med

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Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Cited by 43 publications

References 43 publications

The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

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Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Cited by 43 publications

References 43 publications

The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

The use of antioxidant agents for chemotherapy‐induced peripheral neuropathy treatment in animal models

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

Differential expression of spinal &gamma;-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

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Product

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Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats