Privileged Structures in Drug Discovery 2018
DOI: 10.1002/9781118686263.ch10
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Tetrahydroisoquinolines

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Cited by 5 publications
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“…The tetrahydroisoquinoline contains a nitrogen heterocycle found in many approved drugs in clinical use for several diseases. Medicinal chemistry exploration of this scaffold has yielded analogues with antitubercular, antibacterial, antifungal, and antiviral action [ 19 ]. In a recent study of seventeen THIQs, six demonstrated a moderate but structure-related antibacterial activity against MDR S. Typhi strains comparable to some of the treatment antibiotics [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…The tetrahydroisoquinoline contains a nitrogen heterocycle found in many approved drugs in clinical use for several diseases. Medicinal chemistry exploration of this scaffold has yielded analogues with antitubercular, antibacterial, antifungal, and antiviral action [ 19 ]. In a recent study of seventeen THIQs, six demonstrated a moderate but structure-related antibacterial activity against MDR S. Typhi strains comparable to some of the treatment antibiotics [ 20 ].…”
Section: Introductionmentioning
confidence: 99%