Tetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri(p-tolyl)-phosphine: A structural and biological study

Zartilas, Sotiris; Hadjikakou, Sotiris K.; Hadjiliadis, Nick; Kourkoumelis, Nikolaos; Kyros, L.; Kubicki, Maciej; Baril, Martin; Butler, Ian S.; Karkabounas, Spyridon; Balzarini, Jan

doi:10.1016/j.ica.2007.07.034

Cited by 58 publications

(66 citation statements)

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“…Viability studies to assess toxicity of compounds Different Ag(I) phosphine complexes have shown to target a wide range of malignancies (Berners-Price and Sadler 1988;McKeage et al 1998;Liu et al 2008;Zartilas et al 2009;Kyros et al 2010;Poyraz et al 2011;Kriel and Coates 2012;Goita et al 2013;Banti et al 2014;Yilmaz et al 2014). Therefore, the cell death-inducing abilities of complexes 1-4 were examined in SNO-esophageal cancer cells.…”

Section: Resultsmentioning

confidence: 99%

“…The search for new metal cancer treatments has led to the discovery of metal phosphine complexes that orientate a cubane or tetrahedral geometry, dependent on their ligand ratio (Zartilas et al 2009). The ligands have shown to target different distinctive cellular mechanisms that play a major role in cancer cell death.…”

Section: Introductionmentioning

confidence: 99%

“…However, it was noted that the coordination chemistry of Ag(I) complexes constituted an extremely rich and varied field, with a range of structural types, where 19 different structural types have been identified. Only the work by Zartilas et al (2009), has been published regarding the coordination of P(4-MeC 6 H 4 ) 3 to silver halides, wherein limited data on anticancer testing (IC 50 values only) was reported.…”

Section: Introductionmentioning

confidence: 99%

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The induction of cell death by phosphine silver(I) thiocyanate complexes in SNO-esophageal cancer cells

et al. 2014

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Esophageal cancer is one of the least studied cancers and is found to be prominent in black South African males. It is mainly diagnosed in the late stages, and patients tend to have a low 5-year survival rate of only 10%. Silver is generally used as an antimicrobial agent, with limited reports on anticancer studies. In this study, dimeric silver(I) thiocyanate complexes were used containing a variation of 4-substitued triphenylphosphines, including [AgSCN(PPh(3))(2)](2) (1), [AgSCN{P(4-MeC(6)H(4))(3)}(2)](2) (2), [AgSCN{P(4-FC(6)H(4))(3)}(2)](2) (3) and [AgSCN{P(4-ClC(6)H(4))(3)}(2)](2) (4). All four complexes, with their respective phosphine ligands, PPh(3) (L1), P(4-MeC(6)H(4))(3) (L2), P(4-FC(6)H(4))(3) (L3) and P(4-ClC(6)H(4))(3) (L4), were subjected to in vitro toxicity studies in SNO-esophageal cancer cells, using an alamarBlue(®) assay. Morphological changes, including blebbing and apoptotic body formation, were observed. Phosphatidylserine externalization, a marker of apoptosis, was quantified by flow cytometry. The phosphine ligands L1-L4, on their own, had minimal effect on the malignant while complexes 1-4 resulted in significant cell death. A 10x decreased concentration of these complexes had similar effects than cisplatin, used as the positive control. These complexes show promise as anticancer agents.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The induction of cell death by phosphine silver(I) thiocyanate complexes in SNO-esophageal cancer cells

et al. 2014

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“…Silver complexes have found biomedical uses in antibacterial action 10 . Recently, silver(I) complexes were synthesized and tested for their antitumor activity [11][12][13][14] . In order to investigate the relationship between inflammation and carcinogenesis in the development of new metallotherapeutics, the synthesis of silver(I) complexes with anti-inflammatory drugs, such as aspirin of formulae [Ag(tpp) 3 (asp)](dmf) (tpp ¼ triphenylphosphine, aspH ¼ o-acetylsalicylic acid and dmf ¼ N,Ndimethylformamide) (Figure 1) is reported in previous work 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Stability and binding effects of silver(I) complexes at lipoxygenase-1

Vrontaki

Leonis

Avramopoulos

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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An anti-inflammatory complex of Ag(I), namely [Ag(tpp) Nevertheless, the STD spectra showed that only the complex of salicylic acid is bound to the enzyme. Molecular docking and dynamics were used to complement our study. The complexes were stabilized inside a large LOX-1 cavity by establishing a network of hydrogen bonds and steric interactions. The complex formation with salicylic acid was more favorable. The in silico results provide a plausible explanation of the experimental results, which showed that only the complex with salicylic acid enters the binding cavity.

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“…So, more work needs to be carried out to understand the influence effects of such complexes. In addition, most silver complexes have shown interesting luminescence property [11][12][13] and biological activities [14][15][16][17] . Lung cancer is one of the most common and life-threatening malignancies worldwide.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Crystal Structure of a Polymeric Silver(i) Complex With Cytotoxic Property

Zhang

2015

J. Chil. Chem. Soc.

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A new polymeric silver(I) complex, [Ag 2 (L 1 ) 2 (L 2 )(OH 2 )] n , was obtained by the reaction of 3-aminopyrazine-2-carboxylic acid (HL 1 ), 2-amino-5-methylpyridine (L 2 ) and silver oxide in aqueous ammonia. The complex was characterized by elemental analysis, IR spectra and single crystal X-ray determination. The smallest repeat unit contains a [Ag 2 (L 1 ) 2 (L 2 )(OH 2 )] moiety. The Ag···Ag distance is 7.490(2) Å. One Ag atom is coordinated by three pyrazine N and two carboxylate O atoms from four L 1 ligands, forming a square pyramidal coordination, and the other one is coordinated by one pyrazine N and one carboxylate O atoms from a L 1 ligand, one pyridine N atom from a L 2 ligand, and one water O atom, forming a square planar geometry. In the crystal structure of the complex, the dinuclear silver moieties are linked through L 1 ligands, to form 1D chains along the x-axis direction. The chains are further linked through intermolecular hydrogen bonds in the y-and z-axis directions, forming a 3D network. In addition, there are π···π interactions among the chains. The complex showed effective cytotoxic property on human lung cancer cell line A549.

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Tetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri(p-tolyl)-phosphine: A structural and biological study

Cited by 58 publications

References 44 publications

The induction of cell death by phosphine silver(I) thiocyanate complexes in SNO-esophageal cancer cells

The induction of cell death by phosphine silver(I) thiocyanate complexes in SNO-esophageal cancer cells

Stability and binding effects of silver(I) complexes at lipoxygenase-1

Synthesis, Characterization and Crystal Structure of a Polymeric Silver(i) Complex With Cytotoxic Property

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