Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells

Kumar, Jadi Praveen; Dave, Alpana; Issa, Rahaf; Tabassum, K. A.; Okurowska, Katarzyna; Samarth, Apurwa; Urwin, Lucy; Green, Luke R.; Partridge, Lynda J.; MacNeil, Sheila; Garg, Prashant; Monk, Peter N.; Roy, Sanhita

doi:10.1016/j.jtos.2023.07.001

Cited by 7 publications

(3 citation statements)

References 31 publications

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“… (A) Effect of polypeptide on keratitis. 800cap treated corneal infection and down-regulated cytokines and chemokines ( 129 ). ***p < 0.0005; ns denotes not significant;.…”

Section: The Application Strategies Of Immunopeptides In Ocular Diseasesmentioning

confidence: 99%

“…Tetraspanins (CD9, CD81, CD63, Tspan21 and CD151) can be antibacterial targets, and a CD9 EC2-derived synthetic peptide, 800, shows the ability of reducing Staphylococcus aureus adherence to keratinocytes in human skin models ( 128 ). Further study defined that CD9-derived peptides were useful to treat mice corneal P. aeruginosa infections and promote to release cytokines and chemokine ( Figure 6A ) ( 129 ).…”

Section: The Application Strategies Of Immunopeptides In Ocular Diseasesmentioning

confidence: 99%

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Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications

Tang,

Qu,

Ning

et al. 2024

Front. Immunol.

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Immunopeptides have low toxicity, low immunogenicity and targeting, and broad application prospects in drug delivery and assembly, which are diverse in application strategies and drug combinations. Immunopeptides are particularly important for regulating ocular immune homeostasis, as the eye is an immune-privileged organ. Immunopeptides have advantages in adaptive immunity and innate immunity, treating eye immune-related diseases by regulating T cells, B cells, immune checkpoints, and cytokines. This article summarizes the application strategies of immunopeptides in innate immunity and adaptive immunity, including autoimmunity, infection, vaccine strategies, and tumors. Furthermore, it focuses on the mechanisms of immunopeptides in mediating ocular immunity (autoimmune diseases, inflammatory storms, and tumors). Moreover, it reviews immunopeptides’ application strategies and the therapeutic potential of immunopeptides in the eye. We expect the immune peptide to get attention in treating eye diseases and to provide a direction for eye disease immune peptide research.

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“… (A) Effect of polypeptide on keratitis. 800cap treated corneal infection and down-regulated cytokines and chemokines ( 129 ). ***p < 0.0005; ns denotes not significant;.…”

Section: The Application Strategies Of Immunopeptides In Ocular Diseasesmentioning

confidence: 99%

Section: The Application Strategies Of Immunopeptides In Ocular Diseasesmentioning

confidence: 99%

Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications

Tang,

Qu,

Ning

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In a similar way, novel anti-adhesion peptides have been designed that mainly target the adhesion of the bacteria to the host cells, which is usually the first step to initiate infection. One such approach is tetraspanin derived peptides that have shown potential in inhibiting infection both in vitro and in vivo and also accelerated wound healing in murine corneas ( Jadi et al., 2023 ). Along with these, novel therapeutic interventions in form of antimicrobial peptides can be used to prevent AMR.…”

Section: Potential Solutionsmentioning

confidence: 99%