Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

Gülmen, Şenol; Kiriş, İlker; Narin, Cüneyt; Ceylan, Berit Gökçe; Mermi, Betül; Sütçü, Recep; Meteoğlu, İbrahim

doi:10.1016/j.jss.2008.08.011

Cited by 29 publications

(17 citation statements)

References 40 publications

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“…These finding support those of previous work on the antiinflammatory effects of hydrogen sulfide. 10,16,17 Previous studies have shown that endothelin-1 antagonists can reduce IRI 19 ; however, this study demonstrated that the urinary levels of endothelin-1 were lowest in the control group, and this reduction reached statistical significance compared with the 50 mmol/kg hydrogen sulfide group. In this model, hydrogen sulfide clearly had no effect on endothelial injury although it would be interesting to repeat the experiment with a greater duration of ischemia and more renal damage.…”

Section: Discussion the Role Of Hydrogen Sulfide In A Rodent Model Ofcontrasting

confidence: 61%

Hydrogen Sulfide Reduces Inflammation Following Abdominal Aortic Occlusion in Rats

Hunter

Hosgood

Patel

et al. 2015

Annals of Vascular Surgery

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Section: Discussion the Role Of Hydrogen Sulfide In A Rodent Model Ofcontrasting

confidence: 61%

Hydrogen Sulfide Reduces Inflammation Following Abdominal Aortic Occlusion in Rats

Hunter

Hosgood

Patel

et al. 2015

Annals of Vascular Surgery

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“…The score was 2 if the changes were intermediate and multifocal. The score was 3 if the changes were prominent and extensive (Gulmen et al, 2009;Huang et al, 2015).…”

Section: Histological Examination Of Kidney Injurymentioning

confidence: 99%

Magnolol Reduces Renal Ischemia and Reperfusion Injury via Inhibition of Apoptosis

et al. 2017

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Magnolol, a constituent of the bark of Magnolia officinalis, has been reported to decrease myocardial stunning and infarct size. In this study, we investigated whether magnolol can reduce renal ischemia and reperfusion (I/R) injury. Renal I/R, induced by a 60-min occlusion of bilateral renal arteries and a 24-h reperfusion, significantly increased blood urea nitrogen (BUN) and creatinine levels, and caused histological damage to the kidneys of rats. Apoptosis, as evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and caspase-3 activation, was significantly increased in the kidneys. Furthermore, serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) were significantly elevated, while the interleukin-10 (IL-10) level was suppressed. However, intravenous pretreatment with magnolol at doses of 0.003 mg/kg and 0.006 mg/kg 10 min before renal I/R significantly limited the increases of BUN, creatinine, the histological damage, and apoptosis in the kidneys. The increases in TNF-α, IL-1β, and IL-6, and the decrease in IL-10 were also significantly inhibited. Additionally, magnolol increased Bcl-2 and decreased Bax in the kidneys. Phosphorylation of the prosurvival kinases, including Akt and extracellular signal-regulated kinases 1 and 2 (ERK1/ 2), was elevated, while phosphorylation of the pro-apoptotic mitogen-activated protein kinases, including p38 and c-Jun N-terminal kinase (JNK), was suppressed. In conclusion, magnolol reduces renal I/R injury. The underlying mechanisms for this effect might be related to the prevention of apoptosis, possibly via the inhibition of both extrinsic and intrinsic apoptotic pathways, including the reduction of TNF-α production and the modulation of pro-and anti-apoptotic signaling elements.

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“…Renal tissue samples were evaluated in terms of dilatation of Bowman capsule, degeneration of tubular epithelium, necrosis in tubular epithelium, and vascular congestion. Histopathologic changes were scored on a 4-point semiquantitative scale based on a previously described method as follows: 0 (no changes); 1 (focal, mild changes); 2 (multifocal, intermediate changes); and 3 (extensive, prominent changes) [25].…”

Section: Histopathologic Evaluationmentioning

confidence: 99%

Ozone preconditioning attenuates contrast-induced nephropathy in rats

Kurtoğlu

Durmaz²,

Akgüllü³

et al. 2015

Journal of Surgical Research

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Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

Cited by 29 publications

References 40 publications

Hydrogen Sulfide Reduces Inflammation Following Abdominal Aortic Occlusion in Rats

Hydrogen Sulfide Reduces Inflammation Following Abdominal Aortic Occlusion in Rats

Magnolol Reduces Renal Ischemia and Reperfusion Injury via Inhibition of Apoptosis

Ozone preconditioning attenuates contrast-induced nephropathy in rats

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