2022
DOI: 10.21203/rs.3.rs-1719039/v1
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TGF-β regulates m 6 A RNA methylation after PM 2.5 exposure

Abstract: Atmospheric particulate matter exposure has adverse effects on human health, but its molecular mechanism is complex and need to be explored in depth over time. m6A RNA methylation is an important epigenetic modification that regulates gene expression at the post-transcriptional level. Our previous animal exposure studies found that PM2.5 exposure up-regulated m6A RNA methylation in lung, but the regulatory pathway is currently unclear. PM2.5 can activate transforming growth factor-β (TGF-β), and Smad2/3, a dow… Show more

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