TGF-β1 +869C/T polymorphism increases susceptibility to rheumatoid arthritis in North Indian population

Patel, Sipahee Lal; Prakash, Jaya; Gupta, Varsha

doi:10.1007/s10067-020-05064-w

Cited by 8 publications

(10 citation statements)

References 46 publications

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“…These results agree with findings of the study by Patel et al, 2020 on North Indian RA patients. 16 Also, Panoulas et al, 2009 17 found a significant increase of anti-CCP antibodies in the TT genotype compared with the other two genotypes in UK RA patients. However, the latter group did not find a significant relation between genotypes and ESR, CRP, DAS-28, or RF.…”

Section: Discussionmentioning

confidence: 97%

“…These results agree with those of the study by Patel et al, 2020 who found significantly increased prevalence of T allele and both CT and TT genotypes in North Indian RA patients than in controls. 16 Also, Zhou et al, 2014 18 found that the TT genotype in Chinese was accompanied by a higher susceptibility of RA (OR=1.28, CI= 1.02-1.60, P=0.03). These results were supported by data of a study of C-509T polymorphism of the same gene on UK female twins.…”

Section: Discussionmentioning

confidence: 99%

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Study of transforming growth factor beta 1 gene +869T/C polymorphism in Egyptian rheumatoid arthritis patients and its relation to disease activity

Hassan¹,

Abdul-Mohymen²,

Ahmed³

et al. 2022

EJI

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This study intended to explore the relationship between the +869T/C polymorphism of the transforming growth factor-β1 (TGF-β1) gene and rheumatoid arthritis (RA) predisposition and activity in Egyptian patients. The study involved 30 patients suffering from RA and 30 apparently healthy participants as the control group. The +869T/C polymorphism of the TGF-β1 gene was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) process. The TGF-β1 + 869 CT genotype and CT+TT genotypes in RA patients showed a significant increase than the control group (OR=3.782 and 3.824, CI=1.046-13.680 and 1.150-12.713, P=0.043 and 0.029, respectively). T allele showed a significant increase in patients than in controls (OR= 2.104, CI 1.015- 4.361, P = 0.046). The TGF-β1 +869 CT+TT genotypes were accompanied by higher DAS-28 scores which express higher disease activity, and increased levels of RF, Anti-CCP, ESR, and CRP. In conclusion, the TGF-β1 +869T/C gene polymorphism may be accompanied by an increased predisposition to RA and with its severity in Egyptian RA patients.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Study of transforming growth factor beta 1 gene +869T/C polymorphism in Egyptian rheumatoid arthritis patients and its relation to disease activity

Hassan¹,

Abdul-Mohymen²,

Ahmed³

et al. 2022

EJI

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“…Therefore, in different parts of the body, the pattern of different cells and their markers may exhibit functional heterogeneity. Our earlier study showed that presence of RF could modulate the actual interactions occurring between proinflammatory and antiinflammatory components in the body, which predispose the patient for severe RA 62…”

Section: Discussionmentioning

confidence: 99%

Decreased mRNA expression level of FOXP3 correlate with TNF-α in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis patients: a case control study

Patel

Prakash

Gupta

2021

Current Orthopaedic Practice

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Background:Forkhead box P3 (FOXP3), a transcription factor is thought to be the master regulator of regulatory T (Treg) cells in maintaining peripheral tolerance and autoimmunity. The number and functional capabilities have been reported to be low in several diseases including RA, which affects the immune regulatory action of Treg cells. Proinflammatory cytokines such as tumor necrosis factor α (TNF-α), are important in RA pathogenesis, but the influence on Treg cells is poorly understood. Methods:In the present study, the messenger RNA (mRNA) expressions of FOXP3 and TNF-α in a group of patients with RA (N = 23) and a healthy control group (N = 17) were studied in peripheral blood mononuclear cells (PBMCs). PBMCs were chosen as they are practical samples in which changes caused by disease or therapy can be conveniently monitored. Results:Expression of FOXP3 was lower (P < 0.0001, 0.76 folds) and TNFα gene expression was higher (P < 0.0001, 2.28 folds) in RA patients when compared with the healthy control group. However, a statistically significant correlation could not be established between the FOXP3 and disease activity, but relative mRNA expression of FOXP3 and TNF-α showed a statistically significant correlation (P < 0.0283) in RA patients when compared with the healthy control group. Conclusions:The results suggested that decreased expression of FOXP3 gene and increased level of TNF-α expression in the presence of rheumatoid factor antibodies (RF) may impair the activity of Treg cells with higher TNF-α levels when compared with patients who were negative for RF.

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“…A total amount of 1694 was excluded after the initial screening because of duplication or irrelevance to the search question. After reviewing the full text of the remaining 24 articles, a further five were removed because they failed to meet the inclusion criteria, leaving 19 studies, published between 1987 and 2022, for analysis (Tables 1 and S3) [63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81]. Legend: F, female; M, male; NR, not reported; *, µmol/L; • , mmol/L.…”

Section: Systematic Searchmentioning

confidence: 99%

“…Seventeen studies (18 study groups) reported uric acid concentrations in 2845 RA patients (mean age 57 years, 82.4% females) and 1889 healthy controls (mean age 57 years, 77.5% females) [63][64][65][66][69][70][71][72][73][74][75][76][77][78][79][80][81]. Eleven studies were conducted in Asia [64,66,70,71,73,74,[77][78][79][80][81], four in Europe [63,65,69,76], and two in America [72,75]. Uric acid was measured in plasma in five studies [63,65,69,72,79], and in serum in the remaining 12 [64,66,70,71,[73][74][75][76][77][78]…”

Section: Uric Acidmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of the Association between Uric Acid and Allantoin and Rheumatoid Arthritis

Zinellu

Mangoni

2023

Antioxidants

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Alterations in the circulating concentrations of uric acid and its degradation product, allantoin, might account for the systemic pro-oxidant state and the increased cardiovascular risk in rheumatoid arthritis (RA). We sought to address this issue by conducting a systematic review and meta-analysis of the association between the plasma/serum concentrations of uric acid and allantoin and RA. We searched PubMed, Scopus, and Web of Science from inception to 20 June 2023 for studies comparing plasma/serum concentrations of uric acid and allantoin between RA patients and healthy controls. We assessed the risk of bias with the JBI Critical Appraisal Checklist for analytical studies and the certainty of evidence with the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) Working Group system. In the 19 studies selected for analysis, there were non-significant differences in uric acid concentrations between RA patients and controls (standard mean difference, SMD = 0.11, 95% CI −0.07 to 0.30, p = 0.22; I2 = 87.9%, p < 0.001; low certainty of evidence). By contrast, the concentrations of allantoin were significantly higher in RA patients (SMD = 1.10, 95% CI 0.66 to 1.55, p < 0.001; I2 = 55.6%, p = 0.08; extremely low certainty of evidence). In meta-regression, a significant association was observed between the SMD of uric acid concentrations and body mass index, a risk factor for atherosclerosis and cardiovascular disease (t = 3.35, p = 0.007). Our study has shown a significant increase in the concentrations of the oxidative stress biomarker allantoin in patients with RA. Further research is warranted to investigate the interplay between uric acid, allantoin, redox balance, and cardiovascular disease in this group. (PROSPERO registration number: CRD42023441127).

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TGF-β1 +869C/T polymorphism increases susceptibility to rheumatoid arthritis in North Indian population

Cited by 8 publications

References 46 publications

Study of transforming growth factor beta 1 gene +869T/C polymorphism in Egyptian rheumatoid arthritis patients and its relation to disease activity

Study of transforming growth factor beta 1 gene +869T/C polymorphism in Egyptian rheumatoid arthritis patients and its relation to disease activity

Decreased mRNA expression level of FOXP3 correlate with TNF-α in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis patients: a case control study

A Systematic Review and Meta-Analysis of the Association between Uric Acid and Allantoin and Rheumatoid Arthritis

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