TGF-β1 and -β3 for Mesenchymal Stem Cells Chondrogenic Differentiation on Poly (Vinyl Alcohol)-Chitosan-Poly (Ethylene Glycol) Scaffold

Wee, Ai-Sze; Lim, Chin-Keong; Tan, Sik Loo; Ahmad, Tunku Sara; Kamarul, Tunku

doi:10.1089/ten.tec.2022.0112

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Recently, Wee et al investigated the impact of transforming growth factor-beta 1 (TGF-β1) and -β3 on the chondrogenic differentiation of rBM-MSCs, grown on the PVA-CS-PEG (polyethylene glycol) scaffold in comparison to pellet cultures [ 72 ]. The study reported that utilization of the PVA-CS-PEG scaffold improved both the proliferation and chondrogenic differentiation of rBM-MSCs.…”

Section: Applications Of Pva-cs Hydrogelmentioning

confidence: 99%

“…Enhanced cell proliferation observed in PVA-CS-PEG scaffolds may be attributed to the positive charge of chitosan, which facilitates the adhesion and proliferation of BM-MSCs on the scaffold [ 73 ]. Moreover, the PVA-CS-PEG scaffold offers a beneficial 3D porous structure that enables high-density cell proliferation of BM-MSCs within the scaffold due to its large surface area-to-volume ratio [ 72 ].…”

Section: Applications Of Pva-cs Hydrogelmentioning

confidence: 99%

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Polyvinyl Alcohol-Chitosan Scaffold for Tissue Engineering and Regenerative Medicine Application: A Review

2023

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Tissue engineering and regenerative medicine (TERM) holds great promise for addressing the growing need for innovative therapies to treat disease conditions. To achieve this, TERM relies on various strategies and techniques. The most prominent strategy is the development of a scaffold. Polyvinyl alcohol-chitosan (PVA-CS) scaffold emerged as a promising material in this field due to its biocompatibility, versatility, and ability to support cell growth and tissue regeneration. Preclinical studies showed that the PVA-CS scaffold can be fabricated and tailored to fit the specific needs of different tissues and organs. Additionally, PVA-CS can be combined with other materials and technologies to enhance its regenerative capabilities. Furthermore, PVA-CS represents a promising therapeutic solution for developing new and innovative TERM therapies. Therefore, in this review, we summarized the potential role and functions of PVA-CS in TERM applications.

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Section: Applications Of Pva-cs Hydrogelmentioning

confidence: 99%

Section: Applications Of Pva-cs Hydrogelmentioning

confidence: 99%