Th1 immune response to H. pylori infection varies according to the age of the patients and influences the gastric inflammatory patterns

Melo, Fabrício Freire de; Rocha, Gifone Aguiar; Rocha, Andréia Maria Camargos; Teixeira, Kádima Nayara; Pedroso, S.H.S.P.; Pereira, João Bosco; Castro, Lúcia Porto Fonseca de; Cabral, Mônica Maria Demas Álvares; Carvalho, Simone Diniz; Bittencourt, Paulo Fernando Souto; Oliveira, C. A.; Queiroz, Dulciene Maria Magalhães

doi:10.1016/j.ijmm.2013.11.001

Cited by 32 publications

(18 citation statements)

References 31 publications

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“…One study found that lower levels of IFN-γ were produced in culture supernatants of gastric mucosa tissues from children compared to adults, but no differences in TNF-α, IL-2, or IL-10 were detected regardless of their H. pylori status (17). On the other hand, a recent study showed that in H. pylori infected children, the gastric concentration of IL-1α and TNF-α were significantly higher than that in infected adults whereas IL-2, IL-12p70, and IFN-γ were lower in infected children than in infected adults (42). Of note, differences in cytokine profiles were observed between infected and uninfected individuals in both age groups (42).…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, a recent study showed that in H. pylori infected children, the gastric concentration of IL-1α and TNF-α were significantly higher than that in infected adults whereas IL-2, IL-12p70, and IFN-γ were lower in infected children than in infected adults (42). Of note, differences in cytokine profiles were observed between infected and uninfected individuals in both age groups (42). Epidemiological studies have also suggested that unlike adults, children rarely develop peptic ulcers or gastric atrophy (43–45).…”

Section: Discussionmentioning

confidence: 97%

“…Few studies have evaluated the cytokine responses in the gastric mucosa of this age group and the results are contradictory (17, 41, 42). One study found that lower levels of IFN-γ were produced in culture supernatants of gastric mucosa tissues from children compared to adults, but no differences in TNF-α, IL-2, or IL-10 were detected regardless of their H. pylori status (17).…”

Section: Discussionmentioning

confidence: 99%

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Characterization and Functional Properties of Gastric Tissue-Resident Memory T Cells from Children, Adults, and the Elderly

et al. 2014

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T cells are the main orchestrators of protective immunity in the stomach; however, limited information on the presence and function of the gastric T subsets is available mainly due to the difficulty in recovering high numbers of viable cells from human gastric biopsies. To overcome this shortcoming we optimized a cell isolation method that yielded high numbers of viable lamina propria mononuclear cells (LPMC) from gastric biopsies. Classic memory T subsets were identified in gastric LPMC and compared to peripheral blood mononuclear cells (PBMC) obtained from children, adults, and the elderly using an optimized 14 color flow cytometry panel. A dominant effector memory T (TEM) phenotype was observed in gastric LPMC CD4+ and CD8+ T cells in all age groups. We then evaluated whether these cells represented a population of gastric tissue-resident memory T (TRM) cells by assessing expression of CD103 and CD69. The vast majority of gastric LPMC CD8+ T cells either co-expressed CD103/CD69 (>70%) or expressed CD103 alone (~20%). Gastric LPMC CD4+ T cells also either co-expressed CD103/CD69 (>35%) or expressed at least one of these markers. Thus, gastric LPMC CD8+ and CD4+ T cells had the characteristics of TRM cells. Gastric CD8+ and CD4+ TRM cells produced multiple cytokines (IFN-γ, IL-2, TNF-α, IL-17A, MIP-1β) and up-regulated CD107a upon stimulation. However, marked differences were observed in their cytokine and multi-cytokine profiles when compared to their PBMC TEM counterparts. Furthermore, gastric CD8+ TRM and CD4+ TRM cells demonstrated differences in the frequency, susceptibility to activation, and cytokine/multi-cytokine production profiles among the age groups. Most notably, children’s gastric TRM cells responded differently to stimuli than gastric TRM cells from adults or the elderly. In conclusion, we demonstrate the presence of gastric TRM, which exhibit diverse functional characteristics in children, adults, and the elderly.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Characterization and Functional Properties of Gastric Tissue-Resident Memory T Cells from Children, Adults, and the Elderly

et al. 2014

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“…One additional manuscript focusing on the host immune response to H. pylori infection is worth noting. Freire de Melo et al [46] studied 245 children and 140 adults to assess the Th1 immune response to H. pylori infection. When comparing H. pylori-infected children to adults, a clear pattern emerged whereby the children had a weaker Th1 response.…”

Section: Vaccinesmentioning

confidence: 99%

Immunity, Inflammation, and Vaccines for Helicobacter pylori

D’Elios

Czinn

2014

Helicobacter

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Helicobacter pylori colonizes mucosa, activates Toll-like and Nod-like receptors, and usually elicits a gastric T-helper 1/17 (Th1/Th17) type of immune response. Among several bacterial factors, the secreted peptidyl prolyl cis, trans-isomerase of H. pylori represents a key factor driving Th17 inflammation. A complex and fascinating balance between H. pylori and host factors takes part in the gastric niche and is responsible for the chronicity of the infection. Novel insights into the innate and adaptive responses against H. pylori, dealing with gastric epithelial cells, cytokines, and immune evasion have been elucidated over the past year and are discussed for the development of an effective vaccine.Helicobacter pylori chronically infects the stomach of more than half of the human population and represents the major cause of gastroduodenal diseases. However, only 15-20% of H. pylori-infected patients develop severe pathologies, such as gastric cancer, gastric B-cell lymphoma, peptic ulcer, or gastric autoimmunity, during their lifetime. This fact suggests that the type of immunity elicited by H. pylori may represent an important factor that is able to influence the outcome of the infection toward protection, evasion, or pathology. Here, we present an overview of the major findings on the host response to H. pylori published over the past year.

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“…These conflicting previous results prompted us to evaluate the association between H. pylori infection and ACN using a large health checkup database. We hypothesized that the association between H. pylori infection and ACN is weakened in elderly patients, considering that the immune response to H. pylori infection varies with age and affects gastric inflammation . In this study, we aimed to clarify the association between H. pylori infection and ACN in patients <50 and ≥50 years of age.…”

Section: Introductionmentioning

confidence: 99%

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

Park

et al. 2018

Helicobacter

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Th1 immune response to H. pylori infection varies according to the age of the patients and influences the gastric inflammatory patterns

Cited by 32 publications

References 31 publications

Characterization and Functional Properties of Gastric Tissue-Resident Memory T Cells from Children, Adults, and the Elderly

Characterization and Functional Properties of Gastric Tissue-Resident Memory T Cells from Children, Adults, and the Elderly

Immunity, Inflammation, and Vaccines for Helicobacter pylori

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

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