Th17 and Allergy

Oboki, Keisuke; Ohno, Tomohiro; Saito, Hirohisa; Nakae, Susumu

doi:10.2332/allergolint.r-07-160

Cited by 249 publications

(202 citation statements)

References 146 publications

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“…In this study, we found that increased T cell activation in CHS in the absence of AnxA1 was associated with increased expression of the Th17 transcription factor RORgt and IL-17A, supporting the concept that alterations in Th17 activity underlie the contribution of AnxA1 to regulation of CHS. Deficiency of IL-17 reduces CHS responses to the haptens 2,4-dinitrofluorobenzene, trinitrochlorobenzene, and OXA (49,50), and IL-17 was reported to be involved in the regulation of immune-mediated human skin diseases (51)(52)(53)(54). To our knowledge, our studies are the first to report suppression of IL-17A production by endogenous AnxA1.…”

Section: Discussionmentioning

confidence: 66%

Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell–Dependent Inflammation

Yang

Song

Deane

et al. 2013

The Journal of Immunology

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Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. However, its effects on the adaptive immune response and, in particular, on T cells remain unclear. In this study, we investigated the actions of AnxA1 in three distinct models of T cell–mediated inflammation. In contact hypersensitivity, collagen-induced arthritis, and inflammation induced by OT-II TCR transgenic T cells responding to OVA, AnxA1 deficiency significantly increased Ag-induced T cell proliferation and the resultant level of inflammation. In the contact hypersensitivity model, this was associated with increased adhesion of CD4+ T cells, CD8+ T cells, and neutrophils in the dermal microvasculature, as well as increased T cell expression of RORγt and IL-17A. In collagen-induced arthritis, deficiency of endogenous AnxA1 increased susceptibility to arthritis and Ag-specific T cell activation. Deficiency of AnxA1 also increased OVA-induced cutaneous delayed-type hypersensitivity and IFN-γ and IL-17 release. Transfer experiments using CD4+ T cells from AnxA1−/− mice demonstrated that the absence of AnxA1 solely in T cells resulted in increased inflammatory responses in wild-type recipients. Similarly, experiments using AnxA1−/− OT-II CD4+ T cells demonstrated that the absence of AnxA1 in T cells was sufficient to induce increased Ag-specific CD4+ T cell proliferation in vivo, augment T cell production of IFN-γ, IL-17, TNF, and IL-6, and increase Akt, ERK, and p38 activation. Together, these findings indicate that T cell–expressed AnxA1 functions to attenuate T cell–driven inflammatory responses via T cell–intrinsic effects on intracellular signaling, proliferation, and Th1/Th17 cytokine release.

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Section: Discussionmentioning

confidence: 66%

Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell–Dependent Inflammation

Yang

Song

Deane

et al. 2013

The Journal of Immunology

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“…In this regard, the recent progress in characterizing the proinflammatory IL-17 cytokine family has added an additional layer of complexity on the regulation of allergic inflammation (16). In addition, IL-17A may play a role in the development of various allergic diseases that have classically been considered to be Th2-mediated disorders (17). Moreover, IL-17A may be considered a new biomarker ofdisease progression and allergy severity as recently demonstrated in allergic rhinitis (8)(9).…”

Section: Discussionmentioning

confidence: 99%

Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Ciprandi

Castellazzi

Fenoglio

et al. 2010

Int J Immunopathol Pharmacol

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Th17 is a subset of T helper lymphocytes and exerts pro-inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in the most severe patients with birch allergy studied both outside and during the pollen season. This study aims to compare the frequency of peripheral IL-17-producing T:cells in children with allergic rhinitis and in healthy controls. Ten children with allergic rhinitis and 5 healthy non-allergic subjects were evaluated. Th17 were evaluated by intracellular staining in ex-vivo T cell compartment. Ex-vivo PBMNC evaluation showed that allergic patients had higher frequencies of IL-17 producing T cells, both concerning CD4+ and CD8+ cells. In particular, there is a subset co-expressing IL-17 and IFN-y both for CD4+ and CD8+ cells. In conclusion, this preliminary study suggests a possible role of Th-17 cells in the response to allergens in children.

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“…Th17 cells and their inflammatory mediators attract and promote neutrophil development, and are not known to drive Th2 responses, implying a role for Th17 cells in non-allergic asthma (reviewed in Oboki et al 2008). The role of Th17 cells in allergy is not clear, and needs further investigation.…”

Section: Pregnant Women Havementioning

confidence: 99%

Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy

Sandberg

Frykman

Jonsson

et al. 2009

Journal of Reproductive Immunology

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A Th2-skewed immunity may be necessary for a successful pregnancy and the ability to easily direct immune responses to a Th2-polarized profile may be an evolutionary benefit.The Th2-like immunity associated with allergic disease might generate favourable effects on the maintenance of pregnancy, but also on the development of Th2-like immune responses and allergic disease in the offspring. The aim of this study was to explore, by using IgE as a stable proxy for Th2, the Th1/Th2 balance in allergic and non-allergic women by measuring specific and total IgE antibody levels during pregnancy and after delivery.The specific and total IgE antibody levels were determined by ImmunoCAP technology at five occasions during pregnancy (at gestational week 10-12, 15-16, 25, 35 and 39), as well as 2 and 12 months after delivery. Thirty-six women without and 20 women with allergic symptoms were included, of whom 13 were sensitised with allergic symptoms and 30 nonsensitised without allergic symptoms.The levels of total IgE, but not specific IgE, were increased during early pregnancy, as compared to 12 months after delivery, in the sensitised women with allergic symptoms, but not in the non-sensitised women without allergic symptoms (p<0.01). The increase in total IgE levels during early pregnancy only in the sensitised women with allergic symptoms indicates that allergy is associated with an enhanced Th2 deviation during pregnancy.

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Th17 and Allergy

Cited by 249 publications

References 146 publications

Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell–Dependent Inflammation

Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell–Dependent Inflammation

Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy

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