Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

Noack, Mélissa; Miossec, Pierre

doi:10.1016/j.autrev.2013.12.004

Cited by 778 publications

(644 citation statements)

References 89 publications

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Section: Regulatory T Cell/th17 Cell Balancementioning

confidence: 99%

“…Inhibiting STAT3 using siRNA has been shown to significantly increase the proportion of Treg cells and decrease the proportion of Th17 cells in the CD4 + T cell population from the peripheral blood and synovial fluid of patients with rheumatoid arthritis [108,109]. The inhibition of STAT5 has the counter effects [108,109]. In the same study, no change was found to be induced by STAT3 or STAT5 siRNA in the production of Th1 versus Th2 signature cytokines [108], suggesting that these signalling pathways could provide novel target molecules for the control of Treg cells in the treatment of autoimmune disease, including vitiligo.…”

Section: Regulatory T Cell/th17 Cell Balancementioning

confidence: 99%

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Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

Dwivedi

Kemp

Laddha

et al. 2015

Autoimmunity Reviews

111

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Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes.Regulatory T cells (Tregs) are crucial to the development of self-tolerance and so are major foci in the study of autoimmune pathogenesis of vitiligo. This review will summarise recent findings concerning the role of Tregs in the pathogenesis of vitiligo. In addition, as antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, new strategies that expand or induce de novo generation of Tregs and which are currently being investigated as therapies for other autoimmune diseases, will be discussed. These approaches will highlight the opportunities for Treg cell-based therapeutics in vitiligo.4

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Section: Regulatory T Cell/th17 Cell Balancementioning

confidence: 99%

Section: Regulatory T Cell/th17 Cell Balancementioning

confidence: 99%

Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

Dwivedi

Kemp

Laddha

et al. 2015

Autoimmunity Reviews

111

View full text Add to dashboard Cite

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“…While Th17 stimulate the immune response, Treg have a regulatory activity and, therefore, play a very important role in the maintenance of tolerance and in the control of the expansion and activation of the immune system. 5 The information provided by the studies included in this systematic review might be also relevant for clinical purposes. The Treg/Th17 relationship might help in the understanding of the progressive bone resorption related to periapical lesions.…”

Section: Summary Of Evidencementioning

confidence: 99%

“…4 CD4 + T cells play a regulatory role and help to constrain the effector function of other cell types. 5 More recently, 6 the identification of CD4+ Foxp3+ regulatory T cells (Treg) and T helper 17 cells (Th17) modified the paradigm Th1-Th2. The Treg-Th17 pair has explained the immunity/inflammation process in an increasing number of diseases, including periodontal disease and others involving progressive bone resorption.…”

Section: Introductionmentioning

confidence: 99%

Treg and Th17 cells in inflammatory periapical disease: a systematic review

et al. 2017

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The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.

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“…57 This observation underscores the importance of the balance between Th17 cells and regulatory T cells in autoimmune and inflammatory diseases. 58 Therefore, it is possible that the a-Syn sensitized DC vaccine can decrease brain IL-1 a levels through the generation and activity of regulatory T cells. This hypothesis will be addressed in future studies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease

Ugen

Lin

Bai

et al. 2015

Human Vaccines & Immunotherapeutics

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In order to develop a cell-based vaccine against the Parkinson disease (PD) associated protein a-synuclein (a-Syn) 3 peptides were synthesized based upon predicted B cell epitopes within the full length a-Syn protein sequence. These peptide fragments as well as the full length recombinant human a-Syn (rh-a-Syn) protein were used to sensitize mouse bone marrow-derived dendritic cells (DC) ex vivo, followed by intravenous delivery of these sensitized DCs into transgenic (Tg) mice expressing the human A53T variant of a-Syn. ELISA analysis and testing of behavioral locomotor function by rotometry were performed on all mice after the 5th vaccination as well as just prior to euthanasia. The results indicated that vaccination with peptide sensitized DCs (PSDC) as well as DCs sensitized by rh-a-Syn induced specific anti-a-Syn antibodies in all immunized mice. In terms of rotometry performance, a measure of locomotor activity correlated to brain dopamine levels, mice vaccinated with PSDC or rh-a-Syn sensitized DCs performed significantly better than non-vaccinated Tg control mice during the final assessment (i.e. at 17 months of age) before euthanasia. As well, measurement of levels of brain IL-1a, a cytokine hypothesized to be associated with neuroinflammation, demonstrated that this proinflammatory molecule was significantly reduced in the PSDC and rha-Syn sensitized DC vaccinated mice compared to the non-vaccinated Tg control group. Overall, a-Syn antigensensitized DC vaccination was effective in generating specific anti-a-Syn antibodies and improved locomotor function without eliciting an apparent general inflammatory response, indicating that this strategy may be a safe and effective treatment for PD.

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Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

Cited by 778 publications

References 89 publications

Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

Treg and Th17 cells in inflammatory periapical disease: a systematic review

Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease

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