Th17 Differentiation and Their Pro-inflammation Function

Song, Xiaohe; Gao, Hanchao; Qian, Youcun

doi:10.1007/978-94-017-9487-9_5

Cited by 66 publications

(46 citation statements)

References 338 publications

(465 reference statements)

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“…Th17 cells and their typical cytokine, IL-17, were functionally characterized as tissue inflammatory modulator [31]. It was demonstrated that neutrophil activation and tissue damage were reduced in IL-17 deficient animals and the increased level of IL-17 was related to the pathogenesis of various parasites [32–36].…”

Section: Discussionmentioning

confidence: 99%

Haemonchus contortusexcretory and secretory proteins (HcESPs) suppress functions of goat PBMCsin vitro

Gadahi

Ehsan

et al. 2016

Oncotarget

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Excretory and secretory products (ESPs) of nematode contain various proteins which are capable of inducing the instigation or depression of the host immune response and are involved in the pathogenesis of the worms. In the present study, Haemonchus contortus excretory and secretory products (HcESPs) were collected from the adult worms. Binding of HcESPs to goat peripheral blood mononuclear cells (PBMCs) was confirmed by immune-fluorescence assay. Effects of the HcESPs on cytokine production, cell proliferation, cell migration and nitric oxide (NO) production of PBMCs were checked by co-incubation of HcESPs with goat PBMCs. The results indicated that the production of IL-4 and IFN-γ were significantly decreased by HcESPs in dose dependent manner. On the contrary, the production of IL-10 and IL-17 were increased. Cell migration was significantly enhanced by HcESPs, whereas, HcESPs treatment significantly suppressed the cell proliferation and NO production. These results indicated that the HcESPs played important suppressive regulatory roles on PBMCs and provided highlights to the understanding of the host-parasite interactions.

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Section: Discussionmentioning

confidence: 99%

Haemonchus contortusexcretory and secretory proteins (HcESPs) suppress functions of goat PBMCsin vitro

Gadahi

Ehsan

et al. 2016

Oncotarget

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“…Th17 cells secreted IL‐17A which is the signature cytokine. IL‐17A holds a distinct pro‐inflammatory effect …”

Section: Discussionmentioning

confidence: 99%

Co‐administration of N‐acetylcysteine and dexmedetomidine plays a synergistic effect on protection of LPS‐induced acute lung injury via correcting Th1/Th2/Th17 cytokines imbalance

Qitai

Lin

Chen

et al. 2019

Clin Exp Pharma Physio

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Recently both N‐acetylcysteine (NAC) and Dexmedetomidine (DEX) have shown emerging roles in protection of acute lung injury (ALI). However, how their protective roles work and whether they can provide synergistic effects in ALI remain unknown. Here we explored it from the hot research viewpoint of Th1/Th2/Th17 cytokines balance. Lipopolysaccharide (LPS)‐induced ALI was established and treated with NAC and/or DEX. Mice were divided into Sham group, ALI group, NAC group, DEX group and NAC+DEX group. Mice were sampled at 6, 12 and 24 hours after the model construction. Histopathology, wet to dry ratio and myeloperoxidase (MPO) activity were assessed in lung tissues. Protein concentration and cell count were assessed in bronchoalveolar lavage fluid (BALF). Th1/Th2/Th17 cytokines were assessed in plasma, BALF and lung homogenate. ALI‐induced lung morphological damage, edema and aberrant MPO activity can be attenuated by NAC or DEX and mostly by NAC+DEX. NAC with DEX significantly reduced ALI‐induced protein leakage and cell infiltration in BALF. Th1/Th2/Th17 cytokines imbalance aggravated with ALI progression. NAC, DEX and especially NAC+DEX can effectively correct these unbalanced cytokines. Galectin‐9 and Tim‐3 were transcriptionally up‐regulated in ALI. Combination of NAC with DEX obtained a maximum effect on decreasing Galectin‐9/Tim‐3 expression. In summary, Th1/Th2/Th17 cytokines imbalance is newly found to participate in LPS‐induced ALI. NAC or DEX administration can attenuate ALI by rebalancing Th1/Th2/Th17 cytokines. Their protective roles can be enhanced when co‐administration, because DEX may relieve the Galectin‐9/Tim‐3 axis‐mediated immune suppression.

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“…Nevertheless, IL‐17‐secreting T cells appear to present a relatively heterogeneous population. Typically, Th17 cells produce IL‐17, IL‐21 and IL‐22 . However, IL‐6 or IFN‐ γ , and even IL‐10, can be produced by IL‐17‐secreting CD4 + T cells .…”

Section: Discussionmentioning

confidence: 99%

The proportion of different interleukin‐17‐producing T‐cell subsets is associated with liver fibrosis in chronic hepatitis C

et al. 2017

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Studies have suggested the pivotal role of T helper type 1 (Th1) -related cytokines on the outcome of hepatitis C virus (HCV) infection. Nevertheless, the role of different interleukin-17 (IL-17) -secreting T cells on chronic hepatitis C (CHC) is less clear. Here, the in vivo IL-1β, IL-6, and IL-17 levels were positively correlated with both alanine transaminase (ALT) levels and hepatic lesions. When compared with the control group, CHC patients showed a lower proportion of IL-17-secreting (CD4 and CD8 ) T cells capable of simultaneously producing IL-21. Moreover, the percentage of IL-10-secreting Th17 cells was also lower in CHC patients. Notably, advanced liver lesions were observed among those patients with lower percentage levels of IL-17-producing T cells positive for IL-21, interferon-γ (IFN-γ) and IL-10. In contrast, the severity of hepatic damage was associated with peripheral single IL-17 T cells. The percentage of IL-17 IL-21 IFN-γ (CD4 and CD8 ) T-cell phenotypes was positively associated with plasma CD14 levels. Finally, elevated levels of circulating CD14 were detected among CHC patients with extensive liver damage. In summary, although preliminary, our results suggest that a balance between different IL-17-producing T cells, associated with peripheral levels of CD14, may be a progress marker for liver disease in chronically HCV-infected patients.

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Th17 Differentiation and Their Pro-inflammation Function

Cited by 66 publications

References 338 publications

Haemonchus contortusexcretory and secretory proteins (HcESPs) suppress functions of goat PBMCsin vitro

Haemonchus contortusexcretory and secretory proteins (HcESPs) suppress functions of goat PBMCsin vitro

Co‐administration of N‐acetylcysteine and dexmedetomidine plays a synergistic effect on protection of LPS‐induced acute lung injury via correcting Th1/Th2/Th17 cytokines imbalance

The proportion of different interleukin‐17‐producing T‐cell subsets is associated with liver fibrosis in chronic hepatitis C

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